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Journals / Türk Onkoloji Dergisi / 2009 / Cilt: 24 Sayı: 4

Chronic lymphocytic thyroiditis and tumor-infiltrating lymphocytes combined in thyroid papillary carcinoma

Tiroid papiller karsinomlarında kronik lenfositik tiroidit ve tümörü infiltre eden lenfosit birlikteliği

Nilüfer Onak Kandemir
Figen Barut
Sevinç Keser
Nimet Karadayı
Sibel Bektaş
Banu Doğan Gün
Burak Bahadır
Gamze Yurdakan
Şükrü Oğuz Özdamar
Pages
172–176
Publication Date
2009-05-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION CLT is a frequent finding in TPC, and the presence of TIL is related to CLT.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVES This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT.
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Key Findings & Data:METHODS The study included 61 TPC cases.
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Conclusion & Impact:CONCLUSION CLT is a frequent finding in TPC, and the presence of TIL is related to CLT.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Lenfositik tiroidit · papiller karsinom · tiroid

Abstract

OBJECTIVES This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT. METHODS The study included 61 TPC cases. In each case, the presence of the lymphocyte infiltration in the tumor tissue and nonneoplastic parenchyma was graded semi-quantitatively using a scale of 0 to 3. The cases were classified in two groups, TPC including CLT (Group I) and TPC not including CLT (Group II). RESULTS CLT was detected in 26.3% (Group I) of the TPCs and TIL was observed in 77% of the Group I cases; no lymphoid infiltration compatible with TIL was detected in Group II. A significant difference was observed in the TIL density between Groups I and II. CONCLUSION CLT is a frequent finding in TPC, and the presence of TIL is related to CLT.

Özet

AMAÇ Bu çalışmada, tiroid papiller karsinomlarında (TPK), kronik lenfositik tiroidit (KLT) görülme sıklığı araştırıldı ve tümörü infiltre eden lenfosit (TİL) varlığının KLT ile ilişkisi değerlendirildi. GEREÇ VE YÖNTEM Çalışma kapsamına 61 TPK olgusu dahil edildi. Tümör içi ve tümör çevresi parankimdeki lenfoid infiltrasyon varlığı, her biri için ayrı şekilde, semi-kantitatif olarak 0-3 arasında derecelendi. Olgular grup I (KLT içeren TPK) ve grup II (KLT içermeyen TPK) olmak üzere iki gruba ayrıldı. BULGULAR TPK'ların %26.3'ünde (grup I) KLT saptandı. Grup I'deki olguların %77'sinde TİL görülürken, grup II'deki olgularda TİL ile uyumlu olarak değerlendirilebilecek lenfoid infiltrasyon saptanmadı. Grup I ve grup II'deki olgular arasında TİL yoğunluğu açısından anlamlı farklılık belirlendi. SONUÇ Bulgularımız, TPK'da KLT'nin sık görülen bir bulgu olduğunu ve TİL varlığının KLT ile ilişkili bir parametre olduğunu göstermektedir.

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Cite This Article

Kandemir, N. O., Barut, F., Keser, S., Karadayı, N., Bektaş, S., Gün, B. D., Bahadır, B., Yurdakan, G., Özdamar, Ş. O. (2009). Chronic lymphocytic thyroiditis and tumor-infiltrating lymphocytes combined in thyroid papillary carcinoma. Türk Onkoloji Dergisi, Cilt: 24 Sayı: 4, 172–176. https://ajindex.com/articles/1437120

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