AI Summary & Key Takeaways
AI InsightThis may constitute an anatomical basis for the higher predisposition of hypogonadal males to cardiovascular diseases.
📌 3 Key Takeaways
Abstract
Objectives: The role of androgens in the development of cardiovascular diseases remains controversial. The current studytherefore aimed to determine the changes in the carotid intima-medial thickness of the male rat in surgically-induced hypogonadism.Methods: Twenty-two Rattus norvegicus male rats aged two months were used. The rats were randomly assigned into baseline(4), experimental (9) and control (9) groups. Hypogonadism was surgically induced in the experimental group by bilateralorchiectomy under local anesthesia. At experiment weeks 3, 6 and 9, three rats from each group (experimental and control) wereeuthanized, their common carotid artery harvested, and routine processing was done for paraffin embedding, sectioning andstaining. The photomicrographs were taken using a digital photomicroscope for morphometric analysis.Results: The mean carotid intima-median thickness was 321.97 μm at baseline. There was a progressive increase in the carotidintima-median thickness by 17.6%, 37% and 67.1% of the baseline values in the castrated group at the end of the third, sixthand ninth week respectively (p<0.001). Although the carotid intima-median thickness increased in the non-castrated group withincreasing duration of the study, these increases were not statistically significant (p=0.110). The increase in carotid intima-medianthickness was associated with hyperplasia of the intimal layer as well as increased deposition of collagen fibers in the mediallayer.Conclusion: Androgen deprivation by surgical castration induces a progressive increase in the carotid intima-median thickness. This may constitute an anatomical basis for the higher predisposition of hypogonadal males to cardiovascular diseases.