SavedAdd your journal

Journals / Türkiye Çocuk Hastalıkları Dergisi / 2026 / Cilt: 18 Sayı: 1

Nintedanib Treatment in a Child with Pulmonary Fibrosis

Pulmoner Fibrozis Gelişen Bir Çocukta Nintedanib Deneyimi

Meltem Akgül Erdal(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7507-0770
Didem Alboğa(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8586-5975
Birce Sunman(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9818-8782
Hatice Nursun Özcan(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-4756-4359
Nagehan Emiralioğlu(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1405-8401
Ebru Yalçın(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7325-1981
Deniz Doğru(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9931-9473
Uğur Özçelik(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-1587-5216
Nural Kiper(HACETTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-1261-7393
Pages
71–74
Publication Date
2024-01-10
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, we present the nintedanib experience in a child with PF.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pulmonary fibrosis (PF) in children is a very rare, progressive, and life-threatening condition.
📊
Key Findings & Data:There are advances in the treatment of idiopathic PF in adults with the approval of antifibrotics like nintedanib.
💡
Conclusion & Impact:Here, we present the nintedanib experience in a child with PF.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Bleomisin · Çocuk · İntersitisyel

Abstract

Pulmonary fibrosis (PF) in children is a very rare, progressive, and life-threatening condition. There are advances in the treatment of idiopathic PF in adults with the approval of antifibrotics like nintedanib. However, PF treatment in children is still an inconclusive area that needs to be studied further. Here, we present the nintedanib experience in a child with PF.

Özet

Çocuklarda pulmoner fibrozis (PF) çok nadir görülen, ilerleyici ve yaşamı tehdit eden bir durumdur. Nintedanib gibi antifibrotiklerin onaylanmasıyla erişkinlerde idiyopatik PF tedavisinde ilerlemeler kaydedilmiştir. Bununla birlikte, çocuklarda PF tedavisi hala daha fazla çalışılması gereken sonuçsuz bir alandır. Burada, PF'li bir çocukta nintedanib deneyimini sunuyoruz.

🔖

Cite This Article

Erdal, M. A., Alboğa, D., Sunman, B., Özcan, H. N., Emiralioğlu, N., Yalçın, E., Doğru, D., Özçelik, U., Kiper, N. (2024). Nintedanib Treatment in a Child with Pulmonary Fibrosis. Türkiye Çocuk Hastalıkları Dergisi, Cilt: 18 Sayı: 1, 71–74. https://doi.org/10.12956/tchd.1324744

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Adamson I. Drug-induced pulmonary fibrosis. Environ. Health Perspect 1984;55:25-36.
  2. Bennett JM, Reich SD. Drugs five years later: bleomycin. Ann Intern Med 1979;90:945-8.
  3. Reinert T, Baldotto CSdR, Nunes FAP, Scheliga AAdS. Bleomycin-induced lung injury. J. Cancer Res 2013;2013:1-9.
  4. Braun S, Ferner M, Kronfeld K, Griese M. Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases. Pediatr Pulmonol 2015;50:410-9.
  5. Deterding R, Young LR, DeBoer EM, Warburton D, Cunningham S, Schwerk N, et al. Nintedanib in children and adolescents with fibrosing interstitial lung diseases. Eur Respir J 2023;61:2201512
  6. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205832Orig1s000TOC.cfm.
  7. Abid SH, Malhotra V, Perry MC. Radiation-induced and chemotherapy-induced pulmonary injury. Curr Opin Oncol 2001;13:242-8.
  8. Eigen H, Wyszomierski D. Bleomycin lung injury in children. Pathophysiology and guidelines for management. Am. J Pediatric Hematol Oncol 1985;7:71-8.
  9. Cooper Jr JAD, White DA, Matthay RA. Drug-induced pulmonary disease: Part 1: Cytotoxic drugs. Am Rev Respir Dis 1986;133:321-40.
  10. Graves PR, Siddiqui F, Anscher MS, Movsas B. Radiation pulmonary toxicity: from mechanisms to management. Semin Radiat Oncol 2010;20:201-7.
  11. Nathan N, Sileo C, Thouvenin G, Berdah L, Delestrain C, Manali E, et al. Pulmonary fibrosis in children. J Clin Med 2019;8:1312.
  12. Fyfe A, McKay P. Toxicities associated with bleomycin. JR Coll Physicians Edinb 2010;40:213-5.
  13. Banakh I, Lam A, Tiruvoipati R, Carney I, Botha J. Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence‐base review. Clin Case Rep 2016;4:486-90.
  14. Sakamoto K, Ito S, Hashimoto N, Hasegawa Y. Pirfenidone as salvage treatment for refractory bleomycin-induced lung injury: a case report of seminoma. BMC cancer 2017;17:1-4.
  15. Gundogan BD, Taskinlar S, Arikoglu T, Balci Y, Citak EC. Bleomycin-induced Pneumonitis in a Child Treated With Nintedanib: Report of the First Case in a Childhood. J Pediatr. Hematol Oncol 2022;44:500-2.