AI Summary & Key Takeaways
AI InsightFor these reasons, it can be thought that the gene expressions belonging to SOD were increased in leukemic bone marrow pluripotent stem cells as a part of defense mechanism against to peroxidative damage. [Journal of Turgut Ozal Medical Center 1997;4(1):33-36] KeyWords : Superoxide dismutase, chronic leukemia, pluripotent stem cells
📌 3 Key Takeaways
Abstract
Superoxide dismutase (SOD) enzyme activities were measured in erythrocytes of untreated patients with chronic leukemia by using Podczasy-Wei 's INT reduction method. In both types of chronic leukemia, SOD activities were higher than control with respect to averages but there was a meaningful elevation only in CLL type (p<0.05). For these reasons, it can be thought that the gene expressions belonging to SOD were increased in leukemic bone marrow pluripotent stem cells as a part of defense mechanism against to peroxidative damage. [Journal of Turgut Ozal Medical Center 1997;4(1):33-36] KeyWords : Superoxide dismutase, chronic leukemia, pluripotent stem cells
Özet
Kronik lösemili hastalarda henüz tedaviye başlanmadan, eritrosit içi süperoksit dismutaz (SOD) enzim aktiviteleri Podczasy- Wei 'nin tanımladığı INT redaksiyon metodu kullanılarak ölçüldü. KLL ve KML olarak her iki tip lösemide de SOD aktiviteleri ortalamalar yönünden kontrolden daha yüksek olmasına rağmen, sadece KLL grubunda anlamlı yükseklik vardı (p<0.05). Bu bulgulara göre kronik lösemilerde pluripotent stem celi dediğimiz kemik iliği ana hücrelerinde, SOD 'a ait gen ekspresyonunun peroksidatif hasara karşı savunma mekanizmasının bir parçası olarak artırıldığı düşünülebilir. [Turgut Özal Tıp Merkezi Dergisi 1997;4(1):33-36] Anahtar kelimeler: Süperoksit dismutaz, kronik lösemi, pluripotent stem cell