Journals / Turgut Özal Tıp Merkezi Dergisi / 2026 / Cilt: 7 Sayı: 2

The effects of vitamin E and C combination on hyperbaric oxygen-induced lung toxicity in rats

HİPERBARİK OKSİJENİN SIÇAN SOLUNUM SİSTEMİNDE OLUŞTURDUĞU DEĞİŞİKLİKLERDE VİTAMİN E VE C KOMBİNASYONUNUN ETKİSİ

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Publication Date
2000-04-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We examined the histopathological changes in the respiratory system of the rats induced by hyperbaric oxygen (HBO) administration and the effects of vitamin E and C on these alterations.
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Key Findings & Data:Twenty animals in HBO and HBO+Vit groups were exposed to HBO on a daily basis for 45 days.
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Conclusion & Impact:Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:HBO · akciğer · trakea

Abstract

Objectives: We examined the histopathological changes in the respiratory system of the rats induced by hyperbaric oxygen (HBO) administration and the effects of vitamin E and C on these alterations. Materials and Methods: Thirty adult rats were divided into three groups as control, HBO and HBO+Vit groups. Twenty animals in HBO and HBO+Vit groups were exposed to HBO on a daily basis for 45 days. Additionally, vitamin E and C were administered to the rats in the HB0+ Vit group intraperitoneally during HBO exposure. Results: Histologic examination in HBO group demonstrated epithelial thickening in the trachea, increase in the thickness of alveolar septae, emphysema and mononuclear cell infiltration in lung tissue. Vitamin administration in addition to HBO seemed to reduce the negative effects of HBO on the trachea and lungs of the rats. Conclusions: It is concluded that vitamin E and C have positive effect on limiting the tissue damage caused by HBO. Key words: HBO, lung, trachea, anti oxidant treatment.

Özet

Amaç: Bu çalışmada, sıçan solunum sisteminde hiperbarik oksijen (HBO) uygulamasıyla oluşan yapısal değişiklikler ve bu değişikliklere Eve C vitaminlerinin etkileri araştırıldı. Materyal ve Metot: Otuz yetişkin sıçan, kontrol, HBO ve HBO+Vit grupları şeklinde üç ayrı grupta incelendi. HBO ve HBO+Vit gruplarına 45 gün süreyle HBO uygulandı; HBO+ Vit grubuna ise ek olarak intraperitoneal yoldan Eve C vitaminleri verildi. Bulgular: HBO grubuna ait dokuların histolojik incelemelerinde, trakeada epitel kalın­laşması, akciğerde ise alveoler septumda kalınlaşma, amfizem ve mononükleer hücre infiltrasyonları izlendi. HBO He beraber vitamin uygulamasının trakea ve akciğerde oluşan olumsuz etkileri azalttığı gözlendi. Sonuç: E ve C vitamin kombinasyonunun HBO'ya bağlı gelişen trakea ve akciğer doku hasarını azaltmada etkili olabileceği sonucuna varıldı. Anahtar kelimeler: HBO, akciğer, trakea, antioksidan tedavi.

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Cite This Article

Kıbrıslı, E., Karaöz, E., Gökırmak, M., Yağmurca, M., Irmak, M. K. (2000). The effects of vitamin E and C combination on hyperbaric oxygen-induced lung toxicity in rats. Turgut Özal Tıp Merkezi Dergisi, Cilt: 7 Sayı: 2. https://ajindex.com/articles/1434345

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