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Journals / Mühendislik Bilimleri ve Tasarım Dergisi / 2026 / Cilt: 10 Sayı: 2

MICROPOLLUTANTS IN HOSPITAL WASTEWATER AND TREATMENT IN MEMBRANE BIOREACTORS

HASTANE ATIKSULARINDAKİ MİKROKİRLETİCİLER VE MİKROKİRLETİCİLERİN MEMBRAN BİYOREAKTÖRLERDE GİDERİMİ

İnci Karakaş(ÜSKÜDAR ÜNİVERSİTESİ)0000-0002-3590-3395
Yasemin Kaya(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, MÜHENDİSLİK FAKÜLTESİ, ÇEVRE MÜHENDİSLİĞİ BÖLÜMÜ, ÇEVRE MÜHENDİSLİĞİ PR.)0000-0001-7880-7363
İlda Vergili(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, MÜHENDİSLİK FAKÜLTESİ, ÇEVRE MÜHENDİSLİĞİ BÖLÜMÜ, ÇEVRE MÜHENDİSLİĞİ PR.)0000-0001-9083-3097
Zeren Beril Özçelep(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, MÜHENDİSLİK FAKÜLTESİ, ÇEVRE MÜHENDİSLİĞİ BÖLÜMÜ, ÇEVRE MÜHENDİSLİĞİ PR.)0000-0002-3263-4425
Gülsüm Yılmaz(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, MÜHENDİSLİK FAKÜLTESİ, ÇEVRE MÜHENDİSLİĞİ BÖLÜMÜ, ÇEVRE MÜHENDİSLİĞİ PR.)0000-0002-7692-6024
Pages
722–739
Publication Date
2022-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, the treatment of micropollutants in hospital wastewater in membrane bioreactor (MBR) system and the effects of operation parameters on the removal efficiency were evaluated.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Micropollutants tend to accumulate in the ecosystem due to their low biodegradability and pose a great risk for ecosystem with their toxic, carcinogenic and mutagenic effects.
📊
Key Findings & Data:Generally micropollutants detected at ng levels even in drinking, surface and ground water might have very high concentrations in hospital wastewater.
💡
Conclusion & Impact:In this study, the treatment of micropollutants in hospital wastewater in membrane bioreactor (MBR) system and the effects of operation parameters on the removal efficiency were evaluated.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:Hastane Atıksuyu · Mikrokirletici · MBR

Abstract

Micropollutants tend to accumulate in the ecosystem due to their low biodegradability and pose a great risk for ecosystem with their toxic, carcinogenic and mutagenic effects. Generally micropollutants detected at ng levels even in drinking, surface and ground water might have very high concentrations in hospital wastewater. In our country, the hospital wastewater directly connected to sewage system is discharged into the receiving environment after treating in a pre-treatment or a biological wastewater treatment plant. Advanced treatment methods are needed for micropollutant removal since conventional methods could not be effective. In this study, the treatment of micropollutants in hospital wastewater in membrane bioreactor (MBR) system and the effects of operation parameters on the removal efficiency were evaluated.

Özet

Mikrokirleticiler, biyolojik olarak parçalanabilirliklerinin düşük olması sebebiyle ekosistemde birikme eğilimi göstermekte ve canlı hayatı için toksik, kanserojenik ve mutajenik etkileriyle büyük bir risk oluşturmaktadır. Yaygın olarak içme suları, yüzeysel sular ve yeraltı sularında da nanogram seviyesinde tespit edilen mikrokirleticiler; hastane atıksularında çok yüksek konsantrasyonlarda bulunabilmektedir. Ülkemizde hastane atıksuları doğrudan kanalizasyon sistemine verilerek, evsel atıksularla beraber ön arıtma yapılarak veya biyolojik atıksu arıtma tesisinde arıtıldıktan sonra alıcı ortama verilmektedir. Klasik atıksu arıtma yöntemleriyle atıksulardan giderilemeyen mikrokirleticilerin, ancak ileri atıksu arıtma yöntemleriyle giderimi mümkün olabilmektedir. Bu çalışmada, hastane atıksularındaki mikrokirleticilerin membran biyoreaktörde (MBR) giderimi ve işletme parametrelerinin giderim verimleri üzerine etkisi incelenmiştir.

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Cite This Article

Karakaş, İ., Kaya, Y., Vergili, İ., Özçelep, Z. B., Yılmaz, G. (2022). MICROPOLLUTANTS IN HOSPITAL WASTEWATER AND TREATMENT IN MEMBRANE BIOREACTORS. Mühendislik Bilimleri ve Tasarım Dergisi, Cilt: 10 Sayı: 2, 722–739. https://doi.org/10.21923/jesd.918509

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References (138)

  1. Abtahi, S.M., Petermann, M., Flambard, A.J., Beaufort, S., Terrisse, F., Trotouin, T., Cassan,C.J., Albasi, C., 2018. Micropollutants removal in tertiary moving bed biofilm reactors (MBBRs): contribution of the biofilm and suspended biomass. Science of the Total Environment, 643, 1464-1480.
  2. Aemig Q., Helias, A., Patureau, D., 2020. Impact assessment of a large panel of organic and inorganic micropollutants released by wastewater treatment plants at the scale of France. Water Research, 188, 116524.
  3. Aherne, G.W., English, J., Marks, V., 1985. The role of imuno assay in the analysis of micro contaminants in water samples. Ecotoxicology and Environmental Safety, 9, 79–83.
  4. Akkurt, Ş., Oğuz, M., 2019. Atıksu Arıtma Tesislerinde Mikro Kirleticilerin Arıtılabilirliği. Kahramanmaras Sutcu Imam University Journal of Engineering Sciences, 22(2), 58-77.
  5. Almeida, Â., Calisto, V., Esteves, V., Soares, A.M.V.M., Figueira, E., Freitas, R., 2014. Presence of carbamazepine in coastal systems: effects on bivalves. Aquatic Toxicology, 156, 74–87.
  6. Alsalhya, Q.F., Al-Anib, F. H., Al-Najarb, A. E, 2018. A new Sponge-GAC-Sponge membrane module for submerged membrane bioreactor use in hospital wastewater treatment. Biochemical Engineering Journal, 133, 130–139
  7. Alvarez-Muñoz, D., Huerta, B., Fernandez-Tejedor, M., Rodríguez-Mozaza, S., Barcelóa, D., 2015. Multi-residue method for the analysis of pharmaceuticals and some of their metabolites in bivalves. Talanta. 136, 174-182.
  8. Alvarino, T., Suarez, S., Lema, J.M., Omil, F., 2014. Understanding the removal mechanisms of PPCPs and the influence of main technological parameters in anaerobic UASB and aerobic CAS reactors. Journal of Hazardous Materials. 278, 506-513.
  9. Alvarino, T., Suarez, S., Lema, J., Omil, F., 2018. Understanding the sorption and biotransformation of organic micropollutants in innovative biological wastewater treatment technologies. Science of the Total Environment, 615, 297-306.
  10. Asif, M. B., Ansari, A.J., Chen, S.-S., Nghiem, L.D., Price, W.E., Hai, F.I., 2019. Understanding the mechanisms of trace organic contaminant removal by high retention membrane bioreactors: a critical review. Environmental Science and Pollution Research, 26, 34085–34100.
  11. Asif, M.B., Ren, B., Li, C., Maqbool, T., Zhang, X., Zhang, Z., 2020. Powdered activated carbon–Membrane bioreactor (PAC-MBR): Impacts of high PAC concentration on micropollutant removal and microbial communities. Science of the Total Environment, 745, 141090.
  12. Aydin, S., Aydin, M.E., Ulvi, A., Kilic, H., 2019. Antibiotics in hospital effluents: occurrence, contribution to urban wastewater, removal in a wastewater treatment plant, and environmental risk assessment. Environmental Science and Pollution Research, 26, 544–558.
  13. Bebianno, M.J., Gonzalez-Rey, M., 2015. Ecotoxicological Risk of Personal Care Products and Pharmaceuticals in Claude Amiard-Triquet, Jean-Claude Amiard and Catherine Mouneyrac, Aquatic Ecotoxicology, Advancing Tools for Dealing with Emerging Risks, vol. 16. Academic Press Ch, pp. 383–416.
  14. Benedetti, M., Ciaprini, F., Piva, F., Onorati, F., Fattorini, D., Notti, A., Ausili, A., Regoli, F., 2012. A multidisciplinary weight of evidence approach toward polluted sediments: integrating sediment chemistry, bioavailability, biomarkers responses and bioassays. Environment International, 38, 17–28.
  15. Berendonk, TU., Manaia, C.M., Merlin, C., Fatta-Kassinos, D., Cytryn, E., Walsh, F., Bürgmann, H., Sørum, H., Norström, M., Pons, M.-N., 2015. Tackling antibiotic resistance: the environmental framework. Nature Reviews Microbiology, 13 (5), 310.
  16. Besha, A. T., Gebreyohannes, A.Y., Tufa, R. A., Bekele, D.N., Curcio, E., Giorno, L., 2017. Removal of Emerging Micropollutants by Activated Sludge Process and Membrane Bioreactors and the Effects of Micropollutants on Membrane Fouling: A Review. Journal of Environmental Chemical Engineering, 5(3), 2395-2414
  17. Bo, L., Urase, T., Wang, X. 2009. Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor. Frontiers of Environmental Science & Engineering, 3, 236–240.
  18. Boonnorat, J., Chiemchaisri, C., Chiemchaisri, W., Yamamoto, K., 2014. Microbial adaptation to biodegrade toxic organic micro-pollutants in membrane bioreactor using different sludge sources. Bioresoure Technology, 165, 50-59.
  19. Chen, W., Wong, Y., Huang, T., Chen, W., Lin, J., 2019. Removals of pharmaceuticals in municipal wastewater using a staged anaerobic fluidized membrane bioreactor. International Biodeterioration & Biodegradation, 140, 29–36.
  20. Chitescu, C.L., Kaklamanos, G., Nicolau, A.I., Stolker, A.A., 2015. High sensitive multiresidueanalysis of pharmaceuticals and antifungals in surface water usingU-HPLC-QExactive Orbitrap HRMS. Application to the Danube river basin onthe Romanian territory. Science of the Total Environment, 532, 501–511.
  21. Choi, S., Yoom, H., Son, H., Seo, C., Kim, K., Lee, Y., Kim, Y. M., 2022. Removal efficiency of organic micropollutants in successive wastewater treatment steps in a full-scale wastewater treatment plant: Bench-scale application of tertiary treatment processes to improve removal of organic micropollutants persisting after secondary treatment. Chemosphere, 288, 132629.
  22. Chon, K., Sarp, S., Lee, S., Lee, J. H., Lopez-Ramirez, J.A. Cho, J., 2011. Evaluation of a membrane bioreactor and nanofiltration for municipal wastewater reclamation: Trace contaminant control and fouling mitigation. Desalination, 272, 128-134.
  23. Cirja, M., Ivashechkin, P., Schäffer, A., Corvini, P. F. 2008. Factors affecting the removal of organic micropollutants from wastewater in conventional treatment plants (CTP) and membrane bioreactors (MBR), Reviews in Environmental Science and Bio/Technology, 7,61–78.
  24. Clara, M., Kreuzinger, N., Strenn, B., Gans, O., Kroiss, H., 2005. The solids retention time a suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants. Water Resource, 39, 97–106.
  25. Comber, S., Gardner, M., Sörme, P., Leverett, D., Ellor, B., 2018. Active pharmaceutical ingredients entering the aquatic environment from wastewater treatment works: a cause for concern. Science of the Total Environment, 613–614, 538–547.
  26. CPMP/SWP/4447/00 Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use, 2006. European medicines agency.
  27. Cruz-Morató, C., Lucas, D., Llorca, M., Rodriguez-Mozaz, S., Gorga, M., Petrovic, M., Barceló, D., Vicent, T., Sarrà, M., Marco-Urrea, E., 2014. Hospital wastewater treatment by fungal bioreactor: removal efficiency for pharmaceuticals and endocrine disruptor compounds. Science of the Total Environment, 15, 365–376.
  28. Directive 2001/83/EC of the European Parliament and of the Council of 6 November 2001 On the Community code relating to medicinal products for human use.
  29. Directive 2008/105/EC of the European Parliament and of the Council of 16 December 2008 On environmental quality standards in the field of water policy, amending and subsequently repealing Council Directives 82/176/EEC, 83/513/EEC, 84/156/EEC, 84/491/EEC, 86/280/EEC and amending Directive 2000/60/EC of the European.
  30. Ebele, A.J., Abou-Elwafa Abdallah, M., Harrad, S., 2017. Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment. Emerging Contaminants, 3, 1–16.
  31. Eren, Z., 2018. Su Kaynaklarındaki İlaç Kalıntılarının İleri Oksidasyon Yöntemleri ile Arıtılabilirliğinin İncelenmesi. Academic Platform Journal of Engineering and Science, 6-3, 153-163.
  32. Escher, B.I., Baumgartner, R., Koller, M., Treyer, K., Lienert, J., McArdell, C.S., 2011. Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater, Water Research, 45, 75-92.
  33. Fent, K., Weston, A.A., Caminada, D., 2006. Ecotoxicology of human pharmaceuticals. Aquatic Toxicology, 76, 122–159.
  34. Fernandez-Fontaina, E., Pinho, I., Carballa, M., Omil, F., Lema, J.M., 2013. Biodegradation kinetic constants and sorption coefficients of micropollutants in membrane bioreactors. Biodegradation 24, 165-177.
  35. Fong, P.P., Ford, A.T., 2014. The biological effects of antidepressants on the molluscs and crustaceans: a review. Aquatic Toxicology, 151, 4–13.
  36. Gao, P., Ding, Y., Li, H., Xagoraraki, I., 2012. Occurence of pharmaceuticals in a municipal wastewater treatment plant mass balance and removal processes. Chemosphere, 88, 17-24.
  37. Gobel, A., McArdell, C.S., Joss, A., Siegrist, H., Giger, W., 2007. Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. Science of the Total Environment, 372 (2–3), 361–371.
  38. Gönder, B. Z., Kara, M. E., Celik, O. B., Vergili, I., Kaya, Y., Altinkum, S. M., Bagdatli, Y., Yilmaz, G., 2021. Detailed characterization, antibiotic resistance and seasonal variation of hospital wastewater. Environmental Science and Pollution Research 28, 16380–16393.
  39. Grandclément, C., Seyssiecq, I., Piram, A., Wong-Wah-Chung, P., Vanot, G., Tiliacos, N., Roche, N., Doumenq, P., 2017. From the conventional biological wastewater treatment to hybrid processes, the evaluation of organic micropollutant removal: A review. Water Resources, 111, 297–317.
  40. Gros, M., Rodríguez-Mozaz, S., Barceló, D., 2012. Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry. Journal of Chromatography A, 1248, 104–121.
  41. Gruchlik, Y., Linge, K., Joll, C., 2018. Removal of organic micropollutants in waste stabilisation ponds: A review. Journal of Environmental Management. 206, 202-214.
  42. Guerra, P., Kim, M., Shah, A., Alaee, M., Smyth, S. A., 2014. Occurrence and fate of antibiotic, analgesic/anti-inflammatory and antifungal compounds in five wastewater treatment processes. Science of the Total Environment, 473-474, 235-243.
  43. Guruge, K.S., Goswami, P., Tanoue, R., Nomiyama, K., Wijesekara, R.G.S., Dharmaratne, T.S., 2019. First nationwide investigation and environmental risk assessment of 72 pharmaceuticals and personal care products from Sri Lankansurface waterways. Science of the Total Environment, 690, 683-695.
  44. Gurung, K., Ncibi, M. C., Sillanpää, M., 2019. Removal and fate of emerging organic micropollutants (EOMs) in municipal wastewater by a pilot-scale membrane bioreactor (MBR) treatment under varying solid retention times. Science of the Total Environment, 667, 671-680.
  45. Gwenzi, W., Mangori, L., Danha, C., Chaukura, N., Dunjana, N., Sanganyado, E., 2018. Sources, behaviour, and environmental and human health risks of high-technology rare earth elements as emerging contaminants. Science of the Total Environment, 636, 299-313.
  46. Hai, F. I., Yamamoto, K., Lee, C. H., 2014. Membrane biological reactors. IWA Publishing, UK. ISBN 9781780400655.
  47. Hai, F.I., Li, X., Price, W.E., Nghiem, L.D., 2011a. Removal of carbamazepine and sulfamethoxazole by MBR under anoxic and aerobic conditions. Bioresource Technology, 102 (22), 10386–10390.
  48. Hai, F.I., Nghiem, L.D., Khan, S.J., Asif, M.B., Price, W.E., Yamamoto, K., 2019. Removal of emerging trace organic contaminants (TrOC) by MBR. In: Hai, F.I., Yamamoto, K., Lee, C. (Eds.), Membrane Biological Reactors: Theory, Modeling, Design, Management and Applications to Wastewater Reuse. IWA publishing, London, United Kingdom, pp. 413–468.
  49. Hamon, P., Moulina, P., Ercoleib, L., Marrota, B., 2018. Oncological ward wastewater treatment by membrane bioreactor: Acclimation feasibility and pharmaceuticals removal performances. Journal of Water Process Engineering. 21, 9-26.
  50. Hemmati, A., Dolatabad, M.M., Naeimpoor, F., Pak, A., Mohammdi, T., 2012. Effect of hydraulic retention time and temperature on submerged membrane bioreactor (SMBR) performance. Korean Journal of Chemical Engineering, 29, 369–376.
  51. Hignite, C., Azarnoff, D.L., 1977. Drugs and drugs metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicylic acid in sewage water effluent. Life Sciences, 20, 337–341.
  52. Hocaoglu, S. M., Insel, G., Ubay Cokgor, E., Orhon, D., 2011. Effect of sludge age on simultaneous nitrification and denitrification in membrane bioreactor. Bioresoure Technology, 102, 6665–6672.
  53. Hocaoglu, S. M., Celebi, M.D., Basturk, I., Partal, R., 2021. Treatment-based hospital wastewater characterization and fractionation of pollutants, Journal of Water Process Engineering, 43, 102205.
  54. Isik, O., Erbil, M. C., Abdelrahman, A. M., Ersahin, M. E., Koyuncu, I., Ozgun, H., Demir, I., 2022. Removal of micropollutants from municipal wastewater by membrane bioreactors: Conventional membrane versus dynamic membrane. Journal of Environmental Management 303, 114233.
  55. Janex-Habibi, M. L., Huyard, A., Esperanza, M., Bruchet, A., 2009. Reduction of endocrine disruptor emissions in the environment: the benefit of wastewater treatment. Water Research, 43, 1565-76.
  56. Karakas, I., 2022. Hastane Atıksularının Toz Aktif Karbon İlavesiyle Membran Biyoreaktörde Arıtımı. Yayınlanmamış Doktora Tezi. İstanbul Üniversitesi-Cerrahpaşa, İstanbul.
  57. Kasonga, T. K., Coetzee, A. A. M., Kamika, I., Ngole-Jeme, M. V., Ndombo, M., Momba, B. 2021. Endocrine-disruptive chemicals as contaminants of emerging concern in wastewater and surface water: A review. Journal of Environmental Management, 277, 111485.
  58. Kaya, Y., Ersan, G., Vergili, I., Gönder, B. Z., Yilmaz, G., Dizge, N., Aydiner, C., 2013. The treatment of pharmaceutical wastewater using in a submerged membrane bioreactor under different sludge retention times. Journal of Membrane Science, 442, 72–82.
  59. Kaya, Y., Bacaksiz, M.A., Golebatmaz, U., Vergili, I., Gonder, Z. B., Yilmaz., G., 2016. Improving the performance of an aerobic membrane bioreactor (MBR) treating pharmaceutical wastewater with powdered activated carbon (PAC) addition. Bioprocess and Biosystems Engineering, 39, 661–676.
  60. Kim, M., Guerra, P., Shah, A., Parsa, M., Alaee, M., Smyth, S.A., 2014. Removal of pharmaceuticals and personal care products in a membrane bioreactor wastewater treatment plant. Water Science and Technology, 69, 2221-2229.
  61. Klatte, S., Schaefer, H.-Ch, Hempel, M., 2017. Pharmaceuticals in the environment: a short review on options to minimize the exposure of humans, animals and ecosystems. Sustainable Chemistry and Pharmacy, 5, 61–66.
  62. Kolpin, D.W, Skopec, M., Meyer, M.T., Furlong, E.T., Zaugg, S.D. 2004. Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions. Science of the Total Environment, 328, 119–30.
  63. Köck-Schulmeyer, M., Villagrasa, M., Lopez de Alda, M., Cespedez-Sanchez, R., Ventura, F., Barcelo, D. 2013. Occurrence and behavior of pesticides in wastewater treatment plants and their environmental impact. Science of the Total Environment, 458, 466-76.
  64. Kruglova, A., Kråkström, M., Riska, M., Mikola, A., Rantanen, P., Vahalaa R., Kronberg, L., 2016. Comparative study of emerging micropollutants removal by aerobic activated sludge of large laboratory-scale membrane bioreactors and sequencing batch reactors under low-temperature conditions. Bioresource Technology, 214, 81-88.
  65. Krzeminski, P., Iglesias-Obelleiro, A., Madebo, G., Garrido, J.M., van der Graaf, J.H.J.M., van Lier, J.B., 2012. Impact of temperature on raw wastewater composition and activated sludge filterability in full-scale MBR systems for municipal sewage treatment. Journal of Membrane Science, 423(424), 348–361.
  66. Leiviskä, T., Risteelä, S., 2022. Analysis of pharmaceuticals, hormones and bacterial communities in a municipal wastewater treatment plant – Comparison of parallel full-scale membrane bioreactor and activated sludge systems. Environmental Pollution 292, 118433.
  67. Li, X., Hai, F. I., Nghiem, L. D., 2011. Simultaneous activated carbon adsorption within a membrane bioreactor for an enhanced micropollutant removal. Bioresource Technology, 102(9), 5319-5324.
  68. Li, W.C., 2014. Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environ. Pollut. 187, 193–201.
  69. Li, C., Cabassud, C., Guigui, C., 2015. Evaluation of membrane bioreactor on removal of pharmaceutical micropollutants: a review. Desalination and Water Treatment, 55, 845–858.
  70. Lin, A.Y.-C., Tsai, Y.-T., 2009. Occurrence of pharmaceuticals in Taiwan’s surface waters: impact of waste streams from hospitals and pharmaceutical production facilities. Sci Total Environ 407, 3793–3802
  71. Liu, J., Lu, G., Xie, Z., Zhang, Z., Li, S., Yan, Z., 2015. Occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants. Science of the Total Environment, 511, 54–62.
  72. Liu, W., Song, X., Na, Z., Li, G., Luo, W., 2022. Strategies to enhance micropollutant removal from wastewater by membrane bioreactors: Recent advances and future perspectives. Bioresource Technology, 344, 126322.
  73. Luo, Y., Guo, W., Ngo, H. H., Nghiem, L. D., Hai, F. I., Zhang, J., Wang, X. C., 2014. A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment. Science of the Total Environment, 473–474, 619–641.
  74. Meng, F., Shi, B., Yang, F., Zhang, H., 2007. Effect of hydraulic retention time on membrane fouling and biomass characteristics in submerged membrane bioreactors. Bioprocess Biosyst Engineering, 30, 359–367.
  75. Mezzelani, M., Gorbi, S., Da Ros, Z., Fattorini, D., d'Errico, G., Milan, M., Bargelloni, L., Regoli, F., 2016a. Ecotoxicological potential of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in marine organisms: bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis. Marine Environmental Research, 121, 31–39.
  76. Mezzelani, M., Gorbi, S., Fattorini, D., d'Errico, G., Benedetti, M., Milan, M., Bargelloni, L., Regoli, F., 2016b. Transcriptional and cellular effects of non-Steroidal Anti-inflammatory drugs (NSAIDs) in experimentally exposed mussels, Mytilus galloprovincialis. Aquatic Toxicology, 180, 306–313.
  77. Mezzelani, M., Gorbi, S., Fattorini, D., d'Errico, G., Consolandi, G., Milan, M., Bargelloni, L., Regoli, F., 2018. Long-term exposure of Mytilus galloprovincialis to Diclofenac, Ibuprofen and Ketoprofen: insights into bioavailability, biomarkers and transcriptomic changes. Chemosphere, 198, 238–248.
  78. Mir-Tutusaus, J.A., Parlade, E., Llorca, M., Villagrasa, M., Barcelo, D., Rodriguez-Mozaz, S., Martinez-Alonso, M., Gaju, N., Caminal, G., Sarra, M., 2017. Pharmaceuticals removal and microbial community assessment in a continuous fungal treatment of non-sterile real hospital wastewater after a coagulation-flocculation pretreatment. Water Research, 116, 65-75.
  79. Mir-Tutusaus, J.A., Baccar, R., Caminal, G., Sarrà, M., 2018. Can white-rot fungi be a real wastewater treatment alternative for organic micropollutants removal A review. Water Research, 138, 137-151.
  80. Morabet, R. E., Khan, R. A., Mallick, J., Khan, N. A., Ahmed, S., Dhingra, A., Khan, A. R., Alsubih, M., Alqadhi, S., Bindajam, A., 2020. Comparative study of submerged membrane bioreactor and extended aeration process coupled with tubesettler for hospital wastewater treatment. Alexandria Engineering Journal, 59, 4633-4641.
  81. Morehead, M. S., Scarbrough, C. 2018. Emergence of global antibiotic resistance. Primary Care: Clinics in Office Practice, 45, 467-484.
  82. Nadeema, K., Alliet, M., Plana, Q., Bernier, J., Azimi, S., Rocher, V., Albasi, C., 2022. Modeling, simulation and control of biological and chemical P-removal processes for membrane bioreactors (MBRs) from lab to full-scale applications: State of the art. Science of the Total Environment, 809, 151109.
  83. Nguyen, T., Bui, X. T., Luu, V. P., Nguyen, P. D., Wenshan Guo, W., Ngo, H. H., 2017. Removal of antibiotics in sponge membrane bioreactors treating hospital wastewater: Comparison between hollow fiber and flat sheet membrane systems. 240, 42-49.
  84. Noutsopoulos, C., Koumaki, E., Sarantopoulos, V., Mamais, D., 2019. Analytical and mathematical assessment of emerging pollutants fate in a river system. Journal of Hazardous Materials, 364, 48-58.
  85. Ouarda, Y., Tiwari, B., Azaïs, A., Vaudreuil, M. A., Ndiaye, S. D., Drogui, P., Tyagi, R. D., Sauve, S., Desrosiers, M., Buelna, G., Dube, R., 2018. Synthetic hospital wastewater treatment by coupling submerged membrane bioreactor and electrochemical advanced oxidation process: Kinetic study and toxicity assessment. Chemosphere, 193, 160-169.
  86. Ouarda, Y., Bouchardb, F., Azaïsa, A., Vaudreuilc, M. A., Droguia, P., Tyagia, R. D., Sauvéc, S., Buelnad, G., Dubéd, R., 2019. Electrochemical treatment of real hospital wastewaters and monitoring of pharmaceutical residues by using surrogate models. Journal of Environmental Chemical Engineering 7, 103332.
  87. Özcan. Ö., Kayseri Organize Sanayi Bölgesi Atıksularında Mikrokirleticilerin Pilot Ölçekli Membran Biyoreaktör ve Ters Ozmoz Sistemleri ile Arıtılabilirliğinin İncelenmesi, 2017, Yüksek Lisans Tezi, Erciyes Üniversitesi.
  88. Padhye, L.P., Yao, H., Kung’u, F.T., Huang, C.H., 2014. Year-long evaluation on the occurrence and fate of pharmaceuticals, personal care products, and endocrine disrupting chemicals in an urban drinking water treatment plant. Water Resource, 51, 266–276.
  89. Pal, A., Gin, A.Y.-C., Reinhard, M., 2010. Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Science of the Total Environment, 408, 6062–606.
  90. Pathak, N., Tran, V.H., Merenda, A., Johir, M.A.H., Phuntsho, S., Shon, H., 2020. Removal of organic micro-pollutants by conventional membrane bioreactors and high-retention membrane bioreactors. Applied Sciences. 10 (8), 2969.
  91. Phan, H. V., Hai, F. I., Zhang, R., Kang, J., Price, W. E., Nghiema, L. D., 2016. Bacterial community dynamics in an anoxic-aerobic membrane bioreactor – Impact on nutrient and trace organic contaminant removal. International Biodeterioration & Biodegradation. 109, 61-72.
  92. Parliament and of the Council. Directive 2013/39/EU of the European Parliament and of the Council of 12 August 2013 Amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy Text with EEA relevance.
  93. Pauwels, B., Verstraete, W., 2006. The treatment of hospital wastewater: an appraisal. Journal of Water and Health, 4(4), 405-476.
  94. Peake, B. M., Braund, R., Tong, Y.C.A., Tremblay, L. A., 2016. Detection and presence of pharmaceuticals in the environment. The Life-Cycle of Pharmaceuticals in the Environment. 77-107.
  95. Prasertkulsak, S. Chiemchaisri, C., Chiemchaisri, W., Itonaga, T., Yamamoto, K., 2019. Removals of pharmaceutical compounds from hospital wastewater in membrane bioreactor operated under short hydraulic retention time. Chemosphere, 150, 624-631.
  96. Radjenovic, J., Petrovic, M., Barcelo, D., 2007. Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Analytical and Bioanalytical Chemistry, 387, 1365-1377.
  97. Radjenovic, J., Petrovic, M., Barcelo, D., 2009. Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. Water Resource, 43, 831-841.
  98. QuintilesIMS and its affiliates, 2015. Global Medicines Use in 2020. Outlook and Implications, pp. 9–21.
  99. Richardson, M.L., Bowron, J.M., 1985. The fate of pharmaceutical chemicals in the aquatic environment. Journal of Pharmacy and Pharmacology, 37, 1–12.
  100. Sabri, N., Schmitt, H., Van der Zaan, B., Gerritsen, H., Zuidema, T., Rijnaarts, H., Langenhoff, A., 2018. Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands. Journal of Environmental Chemical Engineering, 8(1), 102245.
  101. Sahar, E., Messalem, R., Cikurel, H., Aharoni, A., Brenner, A., Godehardt, M., Jekel, M., Ernst, M., 2011. Fate of antibiotics in activated sludge followed by ultrafiltration (CAS-UF) and in a membrane bioreactor (MBR). Water Research, 45, 4827-4836.
  102. Santos, J.L., Aparicio, I., Callejon, M., Alonso, E., 2009. Occurrence of pharmaceutically active compounds during 1-year period in wastewaters from four wastewater treatment plants in Seville (Spain). Journal of Hazardous Materials, 164, 1509–1516.
  103. Santos, L.H.M.L.M., Araújo, A.N., Fachini, A., Pena, A., Delerue-Matos, C., Montenegro, M.C.B.S.M., 2010. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. Journal of Hazardous Materials, 175, 45–95.
  104. Sangion, A., Gramatica, P., 2016. PBT assessment and prioritization of contaminants of emerging concern: pharmaceuticals Environmental Research, 147, 297–306.
  105. Seiraa, J., Sablayrolles, C., Montréjaud-Vignoles, M., Albasi, C., Joannis-Cassan, C., 2016. Elimination of an anticancer drug (cyclophosphamide) by a membrane bioreactor: Comprehensive study of mechanisms, 114, 155-163.
  106. Sipma, J, Osuna, B., Collado, N., Monclús, H., Ferrero, G., Comas, J., Rodriguez-Roda, I., 2010. Comparison of removal of pharmaceuticals in MBR and activated sludge systems, Desalination, 250, 653–659.
  107. Sharma, V.K., Johnson, N., Cizmas, L., McDonald, T.J., Kim, H., 2016. A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes. Chemosphere 150, 702–714.
  108. Smith, A.L., Stadler, L.B., Love, N.G., Skerlos, S.J., Raskin, L., 2012. Perspectives on anaerobic membrane bioreactor treatment of domestic wastewater: a critical review. Bioresource Technology, 122, 149–159.
  109. Stevens-Garmon, J., Drewes, J.E., Khan, S.J., MacDonald, J.A., 2011. Sorption of emerging trace organic compounds onto wastewater sludge solids. Water Resource, 45, 3417-3426.
  110. Stasinakis A. S, Gatidou G, Mamais D, Thomaidis N. S, Lekkas T. D., 2008. Occurrence and fate of endocrine disrupters in Greek sewage treatment plants. Water Resource,42,1796–804
  111. Stasinakis, A. S., Thomaidis, N. S., Arvaniti, O. S., Asimakopoulos, A. G., Samaras, V. G., Ajibola, A., Lekkas, T. D., 2013. Contribution of primary and secondary treatment on the removal of benzothiazoles, benzotriazoles, endocrine disruptors, pharmaceuticals and perfluorinated compounds in a sewage treatment plant. Science of the Total Environment, 463(464), 1067–1075.
  112. Stevens-Garmon, J., Dreves, J. E., Khan, S. J., Mc-Donald, J. A., Dickenson, E. R. V., 2011. Sorption of emerging trace organic compounds onto wastewater sludge solids. Water Resource, 45, 3417-3426.
  113. Stülten, D., Zühlke, S., Lamshöft, M., Spiteller, M., 2008. Occurrence of diclofenac and selected metabolites in sewage effluents. Science of the Total Environment, 310–316.
  114. Suárez, S., Reif, R., Lema, J. M., Omil, F., 2012. Mass balance of pharmaceutical and personal care products in a pilot-scale single-sludge system: Influence of T, SRT and recirculation ratio. Chemosphere, 89(2), 164-171.
  115. Tadkaew, N., Sivakumara, M., Khan, S. J., McDonald, J. A., DucNghiema, L., 2010. Effect of mixed liquor pH on the removal of trace organic contaminants in a membrane bioreactor. Bioresource Technology, 101, 1494-1500.
  116. Taheran, M., Brar, S. K., Verma, M., Surampalli, R. Y., Zhang, T.C., Valero, J.R., 2016. Membrane processes for removal of pharmaceutically active compounds (PhACs) from water and wastewaters. Science of the Total Environment, 547, 60-77.
  117. Tambosi, J. L., Sena, R. F., Favier, M., Gebhardt, W., José, H. J., Schröder, H. F., Regina de Fátima Peralta Muniz Moreira, R. F. P. M. (2010). Removal of pharmaceutical compounds in membrane bioreactors (MBR) applying submerged membranes. Desalination, 261, 148-156.
  118. Ternes, T. A., 1998. Occurrence of drugs in German sewage treatment plants and rivers.Water Resource, 32(11),3245–3260.
  119. Ternes, T. A., Joss, A., Siegrist, H., 2004a. Peer reviewed: scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environment Science & Technology, 38, 392A-399A.
  120. Ternes, T. A., Janex-Habibi, M. L., Knacker, T., Kreuzinger, N., Siegrist, H., 2004b. Assessment of Technologies fort he removal of pharmaceuticals and personal care products in sewage and drinking water facilities to improve the indirect potable water reuse (POSEIDON), 61.
  121. Tiwari, B., Sellamuthu, B., Choquette, S. P., Drogui, P., Tyagi, D. R., Vaudreuil, M. A., Sauve, S., Buelna, G., Dube, R., 2021. Acclimatization of microbial community of submerged membrane bioreactor treating hospital wastewater. Bioresource Technology, 319,124223.
  122. Tiwari, B., Sellamuthu, B., Pich´e-Choquette, S., Drogui, P., Tyagi, R.D., Buelna, G., Vaudreuil, M.A., Sauv´e, S., Dube, R., Surampalli, R.Y., 2021a. Compositional microbial-community shift of submerged membrane bioreactor treating hospital wastewater at varying temperatures. Journal of Environmental Engineering, 147 (2), 4020152.
  123. Tran, N. H., Chen, H., Reinhard, M., Mao, F., Yew-Hoong Gin, K., 2016. Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes. Water Research, 104, 461-472.
  124. Trinh, T., van den Akker, B., Coleman, H.M., Stuetz, R.M., Drewes, J.E., Le-Clech, P., Khan, S.J., 2016. Seasonal variations in fate and removal of trace organic chemical contaminants while operating a full-scale membrane bioreactor. Science of the Total Environment, 550, 176-183.
  125. Türkyılmaz, A., Işınkaralar, K., 2020. Sulu Çözeltilerden Aktif Karbon Üzerine Adsorpsiyon ile Antibiyotiklerin (Tetrasiklin ve Penisilin G) Giderimi. Mühendislik Bilimleri ve Tasarım Dergisi, 8(3), 943 – 951.
  126. Urase, T., Kagawa, C., Kikuta, T., 2005. Factors affecting removal of pharmaceutical substances and estrogens in membrane separation bioreactors. Desalination, 178, 107-113.
  127. Verlicchi, P., Galletti, A., Petrovic, M., Barcelo, D., 2010. Hospital effluents as a source of emerging pollutants: an overview of micropollutants and sustainable treatment options, Journal of Hydrology, 389, 416-428.
  128. Verlicchi, P., Al Aukidy, M., Zambello, E., 2015. What have we learned from worldwide experiences on the management and treatment of hospital effluent?- An overview and a discussion on perspectives. Science of the Total Environment, 514, 467–491.
  129. Vyrides, I., Conteras, P.A., Stuckey, D.C., 2010. Post-treatment of a submerged anaerobic membrane bioreactor (SAMBR) saline effluent using powdered activated carbon (PAC). Journal of Hazardous Materials, 177, 836–841.
  130. Weissbrodt, D., Kovalova, L., Ort, C., Pazhepurackel, V.,Moser, R., Hollender, J., Siegrist, H., Mcardell, C.S., 2009. Mass flows of X-ray contrast media and cytostatics in hospital wastewater. Environmental Science & Technology, 43, 4810–4817.
  131. Wijekoon, K.C., Hai, F.I., Kang, J., Price, W.E., Guo, W., Ngo, H. H., Nghiem, L.D., 2013. The fate of pharmaceuticals, steroid hormones, phytoestrogens, UV-filters and pesticides during MBR treatment. Bioresource Technology, 144, 247–254.
  132. Yamamoto, H., Nakamura, Y., Moriguchi, S., Honda, Y., Tamura, I., Hirata, Y., Hayashi, A., Sekizawa, J., 2009. Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: laboratory photolysis, biodegredation, and sorption experiments. Water Research, 43, 351-362.
  133. Yang, Y., Ok, Y.S., Kim, K.-H., Kwon, E.E., Tsang, Y.F., 2017. Occurrences and removal of pharmaceuticals and personal care products (PPCPs) in drinking water and water/ sewage treatment plants: a review. Science of the Total Environment, 596–597, 303–320.
  134. Yilmaz, G., Kaya, Y., Vergili, I., Gönder, B. Z., Özhan, G., Celik, O. B., Altinkum, M. S., Bagdatli, Y., Boergers, A., Tuerk, J., 2017. Characterization and toxicity of hospital wastewaters in Turkey, Environmental Monitoring and Assessment, 189: 55.
  135. Yılmaz, G. (yürütücü), Kaya, Y., Vergili, I., Gönder, B. Z., Özhan, G., Celik, O. B., Altinkum, M. S., Bagdatli, Y., Karakas, I., Ilyasoglu, G., 2018. Hastane atıksularının karakterizasyonu ve toz aktif karbon ilaveli membran biyoreaktörde arıtımı, TÜBİTAK 1001 Projesi, Proje no: 114Y192.
  136. Zhang, Y., Geissen, S.U., Gal, C., 2008. Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies. Chemosphere 73, 1151–1161.
  137. Zhou, H., Wu, C., Huang, X., Gao, M., Wen, X., Tsuno, H., 2010. Occurrence of selected pharmaceuticals and caffeine in sewage treatment plants and receiving Rivers in Beijing, China. Water Environ Research, 82, 2239-2248.
  138. Zhu, Y., Wang, Y., Zhou, S., Jiang, X., Ma, X., Liu, C., 2018. Robust performance of a membrane bioreactor for removing antibiotic resistance genes exposed to antibiotics: Role of membrane foulants. Water Resource, 130, 139–150.