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Journals / Journal of Experimental and Clinical Medicine / 2019 / Volume: 36 Issue: 4

SPECT/CT findings of suspicious vertebral metastasis on planar bone scintigraphy

Sibel Uçak Semirgin(ONDOKUZ MAYIS ÜNİVERSİTESİ, TIP FAKÜLTESİ)
Pages
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Publication Date
2020-03-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, SPECT/CT was found to be able to identify a major part of the vertebral coloumn lesions which were interpreted as suspicious for metastasis and improve the diagnostic value of WPBS.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Whole-body planar bone scintigraphy (WPBS) is a highly sensitive imaging method in the evaluation of bone lesions, but has a limited specificity.
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Key Findings & Data:A total of 56 patients who underwent SPECT/CT imaging due to the suspicious WPBS findings for metastasis on vertebral column were included in this retrospective study.
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Conclusion & Impact:In conclusion, SPECT/CT was found to be able to identify a major part of the vertebral coloumn lesions which were interpreted as suspicious for metastasis and improve the diagnostic value of WPBS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:SPECT/CT · bone scintigraphy · vertebral coloumn

Abstract

Whole-body planar bone scintigraphy (WPBS) is a highly sensitive imaging method in the evaluation of bone lesions, but has a limited specificity. The aim of this study was to evaluate the contribution of SPECT/CT imaging method in the vertebral coloumn lesions which were interpreted as suspicious for metastasis on WPBS. A total of 56 patients who underwent SPECT/CT imaging due to the suspicious WPBS findings for metastasis on vertebral column were included in this retrospective study. Radiotracer accumulations on WPBS and SPECT/CT were determined. Based on the CT findings of SPECT/CT images, radiotracer accumulations were interpreted as benign/degenerative, malignant or suspicious for metastasis. Additional foci detected only with SPECT/CT were determined. A total of 121 foci were evaluated as suspicious for metastasis on WPBS. On SPECT/CT images, 67.8% of these foci were revealed with benign/degenerative lesions, 22.3% were evaluated as malign and 9.9% foci remained suspicious for metastasis. The number of benign/degenerative lesions was significantly higher than that of malign lesions. Pathological radiotracer accumulation was detected in extra 14 foci on the SPECT component of SPECT/CT. All of these foci were evaluated as benign/degenerative on fusion CT images. There was no statistically significant difference found between the total number of foci detected on WPBS and SPECT/CT. In conclusion, SPECT/CT was found to be able to identify a major part of the vertebral coloumn lesions which were interpreted as suspicious for metastasis and improve the diagnostic value of WPBS.

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Cite This Article

Semirgin, S. U. (2020). SPECT/CT findings of suspicious vertebral metastasis on planar bone scintigraphy. Journal of Experimental and Clinical Medicine, Volume: 36 Issue: 4. https://ajindex.com/articles/1423351

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References (23)

  1. Adusumilli, P., Nejadhamzeeigilani, H., Pitts, K., McDermott, G., Scarsbrook, A.F., Vaidyanathan, S., Patel, C.N., Chowdhury,F.U., 2019. Protocol-driven multidetector SPECT/CT: integration of hybrid imaging into the routine workflow of whole-body bone scintigraphy in oncology patients. Clin. Radiol. Oct 7. pii: S0009-9260(19)30555-0. doi: 10.1016/j.crad.2019.09.128. [Epub ahead of print].
  2. Choi, J., Raghavan, M., 2012. Diagnostic imaging and image-guided therapy of skeletal metastases. Cancer Control. 19,102–112.
  3. Cuccurullo, V., Cascini, G.L., Tamburrini, O., Rotondo, A., Mansi L., 2013. Bone metastases radiopharmaceuticals: an overview. Curr. Radiopharm. 6, 41–47.
  4. Disibio, G., French, SW., 2008. Metastatic patterns of cancer: Results from a large autopsy study. Arch. Pathol. Lab. Med. 132, 931-939.
  5. Ghosh, P., 2014. The Role of SPECT/CT in Skeletal Malignancies. Semin. Musculoskelet. Radiol. 18,175–193.
  6. Horger, M., Eschmann, S.M., Pfannenberg, C., Vonthein, R., Besenfelder, H., Claussen, C.D., Bares, R., 2004. Evaluation of combined transmission and emission tomography for classification of skeletal lesions. Am. J. Roentgenol. 183, 655-661.
  7. Horger. M,, Bares, R., 2006. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease. Semin. Nucl. Med. 36, 286-294.
  8. Jiang, L., Han, L., Tan, H., Hu, P., Zhang, Y., Shi, H., 2013. Diagnostic value of 99mTc-MDP SPECT/spiral CT in assessing indeterminate spinal solitary lesion of patients without malignant history. Ann. Nucl. Med. 27, 460-467.
  9. Kobayashi, K., Kusota, T., Nakai, T., Ushijima, Y., Nishimura, T., 2005. Do short-time SPECT images of bone scintigraphy improve the diagnostic value in the evaluation of solitary lesions in the thoracic spine in patients with extraskeletal malignancies?. Ann. Nucl. Med. 19, 557-566.
  10. Love, C., Din, A.S., Tomas, M.B., Kalapparambath, T.P., Palestro, C.J., 2003. Radionuclide bone imaging: an illustrative review. Radiographics. 23, 341-358.
  11. O'Sullivan, G.J., Carty, F.L., Cronin, C.G., 2015. Imaging of bone metastasis: An update. World. J. Radiol. 28, 202–211.
  12. Palmedo, H., Marx, C., Ebert, A., Kreft, B., Ko, Y., Turler, A., Vorreuther, R., Göhring, U., Schild, H.H., Gerhardt, T., Pöge, U., Ezziddin, S., Biersack, H.J., Ahmadzadehfar, H., 2014. Whole-body SPECT/CT for bone scintigraphy: diagnostic value and effect on patient management in oncological patients. Eur. J.Nucl. Med. Mol. Imaging. 41, 59-67.
  13. Rajarubendra, N., Bolton, D., Lawrentschuk, N., 2010. Diagnosis of bone metastases in urological malignancies-an update. Urology. 76, 782-790.
  14. Reinartz, P., Schaffeldt, J., Sabri, O., Zimny, M., Nowak, B., Ostwald, E., Cremerius, U., Buell, U., 2000. Benign versus malignant osseous lesions in the lumbar vertebrae: Differentiation by means of bone SPET. Eur. J. Nucl. Med. 27, 721-726.
  15. Rybak, L.D., Rosenthal, D.I., 2001. Radiological imaging for the diagnosis of bone metastases. Q. J. Nucl. Med. 45, 53-64.
  16. Savelli, G., Maffioli, L., Maccauro, M., De Deckere, E., Bombardieri, E., 2001. Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions. Q. J. Nucl. Med. 45, 27-37.
  17. Sharma, P., Dhull, V.S., Reddy, R.M., Bal, C., Thulkar, S., Malhotra, A., Kumar, R., 2013. Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: Comparison with planar scintigraphy, SPECT, and CT. Diagn. Interv. Radiol. 19, 33-40.
  18. Townsend, D.W., 2008. Dual-modality imaging: Combining anatomy and function. J. Nucl. Med. 49, 938-955.
  19. Utsunomiya, D., Shiraishi, S., Imuta, M., Tomiguchi, S., Kawanaka, K., Morishita, S., Awai, K., Yamashita, Y., 2006. Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT. Radiology. 238, 264-271.
  20. Zhang, Y., Shi, H., Gu, Y., Xiu, Y., Li, B., Zhu, W., Chen, S., Yu, H., 2011. Differential diagnostic value of single-photon emission computed tomography/spiral computed tomography with Tc-99m-methylene diphosphonate in patients with spinal lesions. Nucl. Med. Commun. 32, 1194– 1200.
  21. Zhang, Y., Zhao, C., Liu, H., Hou, H., Zhang, H., 2012. Multiple metastasis-like bone lesions in scintigraphic imaging. J. Biomed. Biotechnol. 957364. doi:10.1155/2012/957364.
  22. Zhang, Y., Shi, H., Cheng, D., Jiang, L., Xiu, Y., Li, B., Gu, Y., Chen, S., 2013. Added value of SPECT/spiral CT versus SPECT in diagnosing solitary spinal lesions in patients with extraskeletal malignancies. Nucl. Med. Commun. 34 (5), 451-458.
  23. Adusumilli, P., Nejadhamzeeigilani, H., Pitts, K., McDermott, G., Scarsbrook, A.F., Vaidyanathan, S., Patel, C.N., Chowdhury,F.U., 2019. Protocol-driven multidetector SPECT/CT: integration of hybrid imaging into the routine workflow of whole-body bone scintigraphy in oncology patients. Clin. Radiol. Oct 7. pii: S0009-9260(19)30555-0. doi: 10.1016/j.crad.2019.09.128. [Epub ahead of print].