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Journals / Journal of Experimental and Clinical Medicine / 2026 / Volume: 38 Issue: 2

Protective Effects Of Trimetazidine Against Hepatic Warm Ischemia/Reperfusion Injury On Rats

Sertaç Ayhan(ORDU ÜNİVERSİTESİ)0000-0002-1915-1306
Tevfik Noyan(Ordu Üniversitesi Tıp Fakültesi)0000-0002-7733-0177
Sevil Işık(ORDU ÜNİVERSİTESİ)0000-0002-3535-6977
Sibel Köktürk(İSTANBUL FACULTY OF MEDICINE)0000-0001-5636-3300
Pages
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Publication Date
2021-04-03
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Trimetazidine could be positively contributing effects to the antioxidant defense mechanism and also the survival of cells by protecting mitochondrial integrity.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aims: Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver diseases that occur in individuals who do not consume a significant amount of alcohol, and the pathogenesis of NAFLD remains undefined.
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Key Findings & Data:Methods: For this aim, Sprague Dawley male rats were separated into 4 groups; control group (group 1, n = 6), sham operated control grup (group 2, n = 6), warm ischemia/reperfusion group (group 3, n=10), and TMZ group (group 4, n=10, administration of TMZ (10 mg/kg) 30-min before fatty liver I/R).
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Conclusion & Impact:Conclusion: Trimetazidine could be positively contributing effects to the antioxidant defense mechanism and also the survival of cells by protecting mitochondrial integrity.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Warm Ischemia · Reperfusion Injury · Non-alcoholic Fatty Liver Disease

Abstract

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of liver diseases that occur in individuals who do not consume a significant amount of alcohol, and the pathogenesis of NAFLD remains undefined. It was aimed to investigate whether the use of Trimetazidine (TMZ) could reduce warm ischemia-reperfusion (I/R) damage after liver ischemia on an experimental NAFLD model in this experimental study. Methods: For this aim, Sprague Dawley male rats were separated into 4 groups; control group (group 1, n = 6), sham operated control grup (group 2, n = 6), warm ischemia/reperfusion group (group 3, n=10), and TMZ group (group 4, n=10, administration of TMZ (10 mg/kg) 30-min before fatty liver I/R). The serum oxidant and antioxidant biochemical markers were measured by ELISA methods. The histopathological evaluation was also performed in the hepatocytes. Results: TMZ was caused to significantly decrease on oxidative stress markers levels which characterized myeloperoxidase (MPO) (p 0.05). While hepatocyte damage as a form of cell groups was observed due to I/R damage, whereas TMZ had caused positive improvements on dilatation of sinusoids, inflammation and the structural integrity of hepatic plaques. Conclusion: Trimetazidine could be positively contributing effects to the antioxidant defense mechanism and also the survival of cells by protecting mitochondrial integrity.

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Cite This Article

Ayhan, S., Noyan, T., Işık, S., Köktürk, S. (2021). Protective Effects Of Trimetazidine Against Hepatic Warm Ischemia/Reperfusion Injury On Rats. Journal of Experimental and Clinical Medicine, Volume: 38 Issue: 2. https://ajindex.com/articles/1423277

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