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Journals / Journal of Experimental and Clinical Medicine / 2026 / Volume: 41 Issue: 2

Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea in down syndrome patients: A systematic review and meta-analysis

Yasmeen Jamal Alabdallat(Hashemite University)0000-0001-6855-3718
Hamza Khaled Alsalhi(Hashemite University)0000-0001-6635-1821
Benyameen Yacoub Mosa(Misr University for Science and Technology)0009-0000-1799-3852
Yousef Hawas(Tanta University)0000-0003-0361-4609
Toka Elboraay(Zagazig University)0000-0001-9606-4196
Ibraheem M. Alkhawaldeh(Mutah University)0000-0002-0187-1583
Jaber H. Jaradat(Mutah University)0000-0002-6488-4664
Obada Ahmad Abunar(Hashemite University)0000-0003-1778-5281
Adam M. Abdallah(King Abdullah University Hospital)0000-0003-0503-1669
Zaid Kamal(King Hussein Cancer Center)0009-0000-9724-5204
Pages
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Publication Date
2024-05-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This meta-analysis provides a comprehensive review and analysis of the available case reports, case series, and cohort studies to evaluate the safety and efficacy of HNS in treating OSA in Down syndrome patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Obstructive sleep apnea (OSA) is highly prevalent in individuals with Down syndrome (DS), affecting more than 50% of this population during childhood and reaching up to 100% in adulthood.
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Key Findings & Data:This disorder poses significant clinical consequences, including impaired cognitive function, developmental delay, and cardiovascular complications.
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Conclusion & Impact:This meta-analysis provides a comprehensive review and analysis of the available case reports, case series, and cohort studies to evaluate the safety and efficacy of HNS in treating OSA in Down syndrome patients.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:OSA · Down Syndrome · Apnea

Abstract

Obstructive sleep apnea (OSA) is highly prevalent in individuals with Down syndrome (DS), affecting more than 50% of this population during childhood and reaching up to 100% in adulthood. This disorder poses significant clinical consequences, including impaired cognitive function, developmental delay, and cardiovascular complications. To address this, direct hypoglossal nerve stimulation (HNS) has been approved as a treatment modality for OSA. Recent studies have shown a significant positive correlation between HNS voltage and post-apnea-hypopnea index (AHI) levels in DS and non-DS patients. However, concerns regarding the reliability of some findings have been raised, emphasizing the need for further research to underline the usefulness of HNS in treating OSA in DS patients. This meta-analysis provides a comprehensive review and analysis of the available case reports, case series, and cohort studies to evaluate the safety and efficacy of HNS in treating OSA in Down syndrome patients.

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Cite This Article

Alabdallat, Y. J., Alsalhi, H. K., Mosa, B. Y., Hawas, Y., Elboraay, T., Alkhawaldeh, I. M., Jaradat, J. H., Abunar, O. A., Abdallah, A. M., Kamal, Z. (2024). Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea in down syndrome patients: A systematic review and meta-analysis. Journal of Experimental and Clinical Medicine, Volume: 41 Issue: 2. https://ajindex.com/articles/1422709

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