Journals / Journal of Experimental and Clinical Medicine / 2026 / Volume: 41 Issue: 3

Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome

Yalçın Boduroğlu(KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ TIP FAKÜLTESİ KARDİYOLOJİ ABD)0000-0002-6327-8849
Bilal İlanbey(KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ)0000-0002-7614-281X
Pages
—
Publication Date
2024-09-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To evaluate the predictive value of the CRP/PAB ratio for the assessment of LA functions in Met-S needs further studies with a large cohort population.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The predictive value of the C-reactive protein / Prealbumin (CRP/PAB) ratio for the assessment of left atrial (LA) functions in metabolic syndrome (Met-S) remains unclear.
📊
Key Findings & Data:We enrolled 100 patients with newly diagnosed Met-S and 53 individuals as a control group.
💡
Conclusion & Impact:To evaluate the predictive value of the CRP/PAB ratio for the assessment of LA functions in Met-S needs further studies with a large cohort population.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:C-reactive protein-to-prealbumin ratio · metabolic syndrome · left atrium function

Abstract

The predictive value of the C-reactive protein / Prealbumin (CRP/PAB) ratio for the assessment of left atrial (LA) functions in metabolic syndrome (Met-S) remains unclear. We enrolled 100 patients with newly diagnosed Met-S and 53 individuals as a control group. Detailed conventional and tissue Doppler echocardiographic examinations were performed, including measurements of volumes and functional indexes of LA. Mean CRP/PAB ratio values were not found to be different between groups (p=0,107). Mean mitral-A, tricuspid-A, and mitral-a’ velocities were found to be significantly different between groups (p-value for all 0,05). After dividing the patients into groups as presenting wleft-right/left ventricular diastolic dysfunction (RVDD- LVDD) or not, again, none of the volumetric and functional indexes of LA were found to be different between groups (p-value for all >0,05). Finally, the CRP/PAB ratio was not found to be correlated with any of the indices of LA in patients with Met-S, while only active emptying volüme of LA was found to be correlated with the CRP/PAB ratio in the control group. We did not find any association between the CRP/PAB ratio and LA functions. To evaluate the predictive value of the CRP/PAB ratio for the assessment of LA functions in Met-S needs further studies with a large cohort population.

🔖

Cite This Article

Boduroğlu, Y., İlanbey, B. (2024). Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome. Journal of Experimental and Clinical Medicine, Volume: 41 Issue: 3. https://ajindex.com/articles/1422640

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (26)

  1. Jahangiry L, Farhangi MA and Rezaei F. Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome. Journal of Health, Population and Nutrition 2017 36:36.
  2. Reddy P, Lent-Schochet D, Ramakrishnan N et al. Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes. Clin Chim Acta. 2019 Sep;4 96:35-44.
  3. Hong GB, Gao PC, Chen YY et al. High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020:13 581–590.
  4. Wang C, Han S, Tong F et al. Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study. Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study. Front. Cardiovasc. Med. 8:684919.
  5. Matsunaga T, Miyata H, Sugimura K et al. Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer. Yonago Acta Medica 2020; 63(1): 8–19
  6. Xie Q, Zhou Y, Xu Z et al. The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury. BMC Nephrology 2011, 12:30.
  7. Yamada T, Haruki S, Minami Y et al. The C-reactive protein to prealbumin ratio on admission and its relationship with outcome in patients hospitalized for acute heart failure. Journal of Cardiology 2021; 78: 308–313.
  8. Abhayaratna WP, Seward JB, Appleton CP et al. Left Atrial Size Physiologic Determinants and Clinical Applications. Journal of the American College of Cardiology 2006; June 20, Vol.47: No 12: 2357-63.
  9. Kurt M, Tanboga IH, Buyukkaya E et al. Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyol Derg 2014; 14: 128-33.
  10. Yilmaz H, Ozcan KS, Sayar N et al. Metabolic Syndrome Is Associated with Atrial Electrical and Mechanical Dysfunction. Med Princ Pract 2015;24:147–152.
  11. Lang RM, Badano LP, Mor-Avi V et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Am Soc Echocardiogr 2015; 28:1-39.
  12. Gudul NE, Karabag T, Sayin MR et al. Atrial conduction times and left atrial mechanical functions and their relation with diastolic func¬tion in prediabetic patients. Korean J Intern Med 2017; 32:286-294.
  13. Mirhafez SR, Ebrahimi M, Karimian MS et al. Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects. European Journal of Clinical Nutrition (2016) 70, 1298–1304.
  14. Xiu S, Chhetri JK, Sun L et al. Association of serum prealbumin with risk of osteoporosis in older adults with type 2 diabetes mellitus: a cross-sectional study. Ther Adv Chronic Dis2019, Vol. 10: 1–10.
  15. Ren H, Zhao L, Liu Y et al. The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction. The Heart Surgery Forum 2021.24 (1). 2020-3307 E153-157.
  16. Wang W, Ren D, Wang CS et al. High sensitivity C-reactive protein to prealbumin ratio measurement as a marker of the prognosis in acute coronary syndrome. Scientific Reports. Natureresearch 2019; 9:11583.
  17. Parameswaran R and Kalman JM. Left Atrium and Cardiovascular Risk: Does Functionality Matter More Than Size? J Am Heart Assoc. 2018;7: e008930.
  18. Lee HC, Shin SJ, Huang JK et al. The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome. Lipids in Health and Disease 2020; 19:210.
  19. Shigematsu Y, Norimatsu S, Ogimoto A et al. The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients. Hypertension Research (2009) 32, 500–504.
  20. Allam SRH, Sheredah AEAR, Al-Deftar M et al. Strain/Strain Rate Imaging of Impaired Left Atrial Function in Patients with Metabolic Syndrome. The Egyptian Journal of Hospital Medicine (April 2019) Vol. 75 (3), Page 2467-2474.
  21. Akil MA, Akil E, Bilik MZ et al. The relationship between atrial electromechanical delay and left atrial mechanical function in stroke patients. Anatol J Cardiol 2015; 15: 565-70.
  22. Barbier P, Adriano EP, Lucini D, et al. Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”. J. Pers. Med. 2022, 12, 1044.
  23. Vukomanovic V, Suzic-Lazic J, Celic V. et al. Is there association between left atrial function and functional capacity in patients with uncomplicated type 2 diabetes? Int J Cardiovasc Imaging. 2020 Jan;36(1):15-22.
  24. Gulmez O, Parildar H, Cigerli O, Demirdag N. Assessment of left atrial function in patients with type 2 diabetes mellitus with a disease duration of six months. Cardiovasc J Afr 2017; 29: 82–87.
  25. Yilmaz H, Ozcan KS, Sayar N et al. Metabolic Syndrome Is Associated with Atrial Electrical and Mechanical Dysfunction. Med Princ Pract 2015;24:147–152.
  26. Ren H, Zhao L, Liu Y et al. The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction. The Heart Surgery Forum 2021.24 (1). 2020-3307 E153-157.