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Journals / Journal of Experimental and Clinical Medicine / 2026 / Volume: 42 Issue: 2

Immunohistological examination of thyroid hormone receptor expressions in placenta in maternal hypothyroidism

Gökçen Bilici(Dokuz Eylül Üniversitesi)0000-0003-0027-9286
Serap Cilaker Mıcılı(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9830-0989
Pages
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Publication Date
2025-06-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results showed that thyroid hormone receptors are associated with maternal hypothyroidism.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Thyroid hormones are necessary for the development of a healthy fetus and placenta.
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Key Findings & Data:We evaluated term placentas in two groups: control (n=5) and hypothyroidism (n=5).
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Conclusion & Impact:The results showed that thyroid hormone receptors are associated with maternal hypothyroidism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:maternal hypothyroidism · placenta · thyroid hormone receptors

Abstract

Thyroid hormones are necessary for the development of a healthy fetus and placenta. In our study, we evaluated the thyroid hormone receptor expressions in the placentas of pregnant women with hypothyroidism. We evaluated term placentas in two groups: control (n=5) and hypothyroidism (n=5). THRα and THRß were expressed in the placenta, especially in syncytiotrophoblasts, and also in placental macrophages. THRα expression was decreased in the hypothyroid group compared to the control group, but it was statistically non-significant (p=0,850) . THRß expression was decreased in the hypothyroid group compared to the control group at a statistically significant level (p=0,004). The results showed that thyroid hormone receptors are associated with maternal hypothyroidism.

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Cite This Article

Bilici, G., Mıcılı, S. C. (2025). Immunohistological examination of thyroid hormone receptor expressions in placenta in maternal hypothyroidism. Journal of Experimental and Clinical Medicine, Volume: 42 Issue: 2. https://ajindex.com/articles/1422589

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