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Journals / Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi / 2026 / Cilt: 20 Sayı: 1

Evaluation of fetal thymus size in pregnancies complicated with fetal growth restriction

Fetal büyüme kısıtlılığı ile komplike gebeliklerde fetal timus boyutunun değerlendirilmesi

Seyit Ahmet Erol(Konya Şehir Hastanesi)0000-0002-2494-4896
Nur Gözde Kulhan(Konya Şehir Hastanesi)0000-0002-7463-9101
Oğuzhan Günenc(Konya Şehir Hastanesi)0000-0003-4373-5245
Pages
1617–1624
Publication Date
2023-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Moreover, fetal TTR might be a sonographic indicator for predicting adverse perinatal outcomes.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To evaluate fetal thymus size using the thymic-thoracic ratio (TTR) in women with a pregnancy complicated with fetal growth restriction (FGR) and to assess the relationship with adverse perinatal outcomes.
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Key Findings & Data:Materials and Method: A total of 35 pregnant women with FGR and 42 healthy pregnant women with similar demographic characteristics were included in this prospective study.
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Conclusion & Impact:Moreover, fetal TTR might be a sonographic indicator for predicting adverse perinatal outcomes.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Fetal büyüme kısıtlılığı · timik-torasik oran · ultrason

Abstract

Aim: To evaluate fetal thymus size using the thymic-thoracic ratio (TTR) in women with a pregnancy complicated with fetal growth restriction (FGR) and to assess the relationship with adverse perinatal outcomes. Materials and Method: A total of 35 pregnant women with FGR and 42 healthy pregnant women with similar demographic characteristics were included in this prospective study. In the FGR group, cases with pathological doppler flow parameters of absent end-diastolic flow (AEDF) in an umbilical artery and cerebroplacental ratio (CPR) 0.05). The fetal TTR was determined to be significantly lower in the FGR group than in the control group (0.37±0.02 [0.33-0.42] and 0.40±0.02 [0.36-0.45], p<0.001, respectively). A statistically significant, negative moderate correlation was determined between fetal TTR and the EFW <3rd percentile, pathological doppler flow (AEDF and CPR<1) (r= -0.703, r= -0.588, r= -0.383, r= -0.418 and p<0.001, p<0.001, p=0.023, p=0.012, respectively). Conclusion: This is the first study to have evaluated the fetal TTR measurement in FGR-complicated pregnancies. A lower fetal TTR supports the relationship between FGR and fetal thymic involution. Moreover, fetal TTR might be a sonographic indicator for predicting adverse perinatal outcomes.

Özet

Amaç: Fetal büyüme kısıtlılığı (FBK) ile komplike gebeliği olan kadınlarda timik-torasik oran (TTR) kullanarak fetal timus boyutunu değerlendirmek ve olumsuz perinatal sonuçlarla olan ilişkisini belirlemek. Gereçler ve Yöntem: Bu prospektif çalışmaya FBK ile komplike toplam 35 gebe kadın ile benzer demografik özellikte sağlıklı toplam 42 gebe kadın dahil edildi. FBK grubunda, patolojik doppler akım parametreleri olan umbilikal arterde end-diyastolik akım kaybı (EDAK) ve serebroplasental oran (SPO) 0.05). Fetal TTR'nin FBK grubunda kontrol grubuna göre anlamlı derecede daha düşük olduğu belirlendi (0.37±0.02 [0.33-0.42] ve 0.40±0.02 [0.36-0.45], p<0.001, sırasıyla). Fetal TTR ile TFA <3. persantil, patolojik doppler akımı (EDAK ve SPO <1) arasında istatistiksel olarak anlamlı, orta düzeyde negatif bir korelasyon saptandı (r= -0.703, r= -0.588, r= -0.383, r= -0.418 ve p<0.001, p<0.001, p=0.023, p=0.012, sırasıyla). Sonuç: FBK ile komplike gebeliklerde fetal TTR ölçümünün değerlendirildiği ilk çalışmadır. Düşük fetal TTR, FBK ile fetal timik involusyon ilişkisini desteklemektedir. Bununla birlikte, olumsuz perinatal sonuçların öngörüsünde fetal TTR bir sonografik indikatör olabilir.

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Cite This Article

Erol, S. A., Kulhan, N. G., Günenc, O. (2023). Evaluation of fetal thymus size in pregnancies complicated with fetal growth restriction. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, Cilt: 20 Sayı: 1, 1617–1624. https://doi.org/10.38136/jgon.1195083

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