Journals / Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi / 2026 / Cilt: 22 Sayı: 1

Are hematological markers helpful in predicting the difference between endometrial intraepithelial neoplasia and grade 1 endometrioid endometrial carcinoma in the preoperative period?

Hematolojik belirteçler preoperatif dönemde endometriyal intraepitelyal neoplazi ve grade 1 endometrioid endometriyal karsinom arasındaki farkı predikte etmede yardımcı mıdır?

Mete Sargın(Uzm.Dr. Prof. Dr. Alaeddin Yavaşca Devlet Hastanesi)0009-0001-9698-4547
Mustafa Şahin(ANKARA ŞEHİR HASTANESİ)0000-0002-2126-6479
Hakan Raşit Yalçın(Ankara Bilkent Şehir Hastanesi)0000-0002-9027-1351
Pages
101–106
Publication Date
2025-03-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, more comprehensive studies are required to support this result and include it in our daily practice.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To evaluate the role of hematological markers in preoperatively predicting the difference in patients with endometrial intraepithelial neoplasia and grade 1 endometrioid type endometrial cancer.
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Key Findings & Data:Materials and Methods: The data of a total of 298 patients, including 75 patients with EIN as a result of preoperative endometrial biopsy and 223 patients with grade 1 endometrioid type endometrial cancer in a tertiary center between September 2019 and July 2023, were retrospectively examined from the hospital database.
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Conclusion & Impact:However, more comprehensive studies are required to support this result and include it in our daily practice.
🔬Design:Klinik Araştırma
📍Scope:2019 Verileri
⚙️Variables:hematolojik paremetreler · inflamatuar prognostik indeks · endometrial intraepiteliyal neoplazi

Abstract

Aim: To evaluate the role of hematological markers in preoperatively predicting the difference in patients with endometrial intraepithelial neoplasia and grade 1 endometrioid type endometrial cancer. Materials and Methods: The data of a total of 298 patients, including 75 patients with EIN as a result of preoperative endometrial biopsy and 223 patients with grade 1 endometrioid type endometrial cancer in a tertiary center between September 2019 and July 2023, were retrospectively examined from the hospital database. Clinical and biochemical results were compared between the two groups. Results: The difference between age and inflammatory prognostic index values between the patient groups with endometrial intraepithelial neoplasia and grade 1 endometrioid type endometrial cancer was statistically significant (p<0.001 and p=0.006, respectively). There was no statistically significant difference between the patient groups in terms of neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, C-reactive protein, albumin, Glasgow Prognostic Score, Prognostic Nutritional Index values. Conclusion: Inflammatory prognostic index may support the preoperative discrimination of patients with endometrial intraepithelial neoplasia and grade 1 endometrioid type endometrial cancer. However, more comprehensive studies are required to support this result and include it in our daily practice.

Özet

Amaç: Sistemik inflamatuar belirteçlerin endometrial intraepitelyel neoplazili ve grade 1 endometrioid tip endometrium kanserli hastalardaki farkı predikte etmedeki rolünü değerlenmektir. Gereç ve Yöntem: Eylül 2019- Temmuz 2023 tarihleri arasında tersiyer bir merkezde preoperatif endometrial biyopsi sonucu EİN olan 75 hasta ve grade 1 endometrioid tip endometrial kanser olan 223 hasta olmak üzere toplam 298 hastanın verileri hastane veri tabanından retrospektif olarak incelendi. İki grup arasındaki klinik ve biyokimyasal sonuçlar karşılaştırıldı. Bulgular: Endometrial intraepitelyal neoplazili ve grade 1 endometrioid tip endometrium kanserli hasta grupları arasında yaş ve inflamatuar prognostik indeks değerleri arasındaki fark istatistiksel olarak anlamlıydı(sırasıyla p<0.001 ve p=0.006 ). Hasta grupları arasında nötrofil, lenfosit, monosit, platelet, nötrofil/lenfosit oranı, platelet/lenfosit oranı, C-reaktif protein, albumin, Glasgow Prognostik Skoru, Prognostik Nutrisyonel İndeks değerleri açısından istatistiksel olarak anlamlı farklılık yoktu. Sonuç: İnflamatuar prognostik indeks, endometrial intraepitelyel neoplazili ve grade 1 endometrioid tip endometrium kanserli hastaların preoperaptif ayırt edilmesine yardımcı olabilir. Ancak bu sonucun desteklenip günlük pratiğimizde yer alması için daha kapsamlı çalışmalar gereklidir.

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Cite This Article

Sargın, M., Şahin, M., Yalçın, H. R. (2025). Are hematological markers helpful in predicting the difference between endometrial intraepithelial neoplasia and grade 1 endometrioid endometrial carcinoma in the preoperative period?. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, Cilt: 22 Sayı: 1, 101–106. https://doi.org/10.38136/jgon.1468523

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References (2)

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