Journals / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Sayı: 29 Özel Sayı

AI Enabled Digital Twin Approaches in Nutrition and Dietetics: Evidence, Potential, and Limitations

Beslenme ve Diyetetikte Yapay Zekâ Destekli Dijital İkiz Yaklaşımları: Kanıtlar, Potansiyel ve Sınırlılıklar

Burcu Aksoy Canyolu(İSTANBUL MEDENİYET ÜNİVERSİTESİ)0000-0003-0205-4099
Pages
153–162
Publication Date
2026-08-02
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This narrative review defines the concept of DT from a healthcare perspective, summarizes its current applications in nutrition and dietetics, and outlines its high potential, key limitations, and challenges.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Rapid advances in technology, particularly the integration of artificial intelligence (AI) technology into our lives, have increased interest in digital twin (DT) technology, which is a dynamic virtual model of a physical system.
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Key Findings & Data:In the healthcare sector, DT is also seen as having the potential to bring about lasting transformation in areas such as drug development, advanced diagnostics and preventive treatment, clinical research, and personalized medicine.
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Conclusion & Impact:This narrative review defines the concept of DT from a healthcare perspective, summarizes its current applications in nutrition and dietetics, and outlines its high potential, key limitations, and challenges.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Dijital ikiz · yapay zeka · insan dijital ikizi

Abstract

Rapid advances in technology, particularly the integration of artificial intelligence (AI) technology into our lives, have increased interest in digital twin (DT) technology, which is a dynamic virtual model of a physical system. In the healthcare sector, DT is also seen as having the potential to bring about lasting transformation in areas such as drug development, advanced diagnostics and preventive treatment, clinical research, and personalized medicine. In the coming years, DT is expected to enable personalized nutrition by integrating genetic, epigenetic, microbiome, metabolic, immunological, and lifestyle data into comprehensive virtual models. This new paradigm has the potential to provide groundbreaking opportunities for the management and prevention of various nutrition-related diseases, obesity, and support healthy aging. Although early research in the field of nutrition is promising, various challenges and limitations persist, including data standardization, privacy, data quality and security, ethical concerns, high costs, scalability, and clinical validation issues. Currently, the use of DT in the field of nutrition and dietetics remains in the proof-of-concept stage. Nevertheless, it is anticipated that as these limitations are overcome over time, this technology will transform and guide global healthcare systems. This narrative review defines the concept of DT from a healthcare perspective, summarizes its current applications in nutrition and dietetics, and outlines its high potential, key limitations, and challenges.

Özet

Teknolojideki hızlı ilerlemeler, özellikle yapay zeka teknolojisinin yaşamın pek çok alanına girmesiyle birlikte, fiziksel sistemlerin dinamik sanal modelleri olan dijital ikizler farklı sektörlerde kullanılmaya başlanmıştır. Hayati sektörlerden sağlık sektöründe de dijital ikiz teknolojisi; ilaç geliştirme, ileri tanı ve koruyucu tedavi, klinik araştırmalar ve kişiselleştirilmiş tıp alanlarında kalıcı dönüşüm vaat eden yüksek potansiyeller olarak görülmektedir. Gelecek yıllarda dijital ikizlerin, genetik, epigenetik, mikrobiyom, metabolik, bağışıklık ve yaşam tarzı verilerini bütüncül bir şekilde değerlendirerek kişiselleştirilmiş beslenmeyi mümkün kılması beklenmektedir. Bu yeni paradigma; obezite başta olmak üzere beslenmeyle ilişkili birçok hastalığın yönetimi, önlenmesi ve sağlıklı yaş almanın desteklenmesi açısından çığır açıcı araçlar sunma potansiyeline sahiptir. Mevcut durumda beslenme alanında yapılan çalışmalar umut vaad ederken; veri standardizasyonu, gizlilik, veri kalitesi ve güvenliği, etik kaygılar, yüksek maliyet, ölçeklenebilirlik ve klinik doğrulama gibi çeşitli zorluk ve sınırlamalar devam etmektedir. Bu nedenle beslenme ve diyetetik alanında dijital ikiz teknolojisinin kullanımı henüz kanıtlanma aşamasındadır. Ancak zaman içinde bu sınırlamaların aşılmasıyla bu teknolojinin sağlık hizmetlerini ve sistemini evrensel ölçekte dönüştürücü ve yönlendirici bir konuma geçeceği öngörülmektedir. Bu geleneksel derlemede sağlık alanı perspektifinden dijital ikiz kavramı tanımlanmış; beslenme ve diyetetik alanında dijital ikiz uygulamalarının mevcut durumu sunulmuş; ayrıca yüksek potansiyelinin yanında karşılaşılan sınırlamalar ve zorluklara yer verilmiştir.

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Cite This Article

Canyolu, B. A., Şen, N. (2026). AI Enabled Digital Twin Approaches in Nutrition and Dietetics: Evidence, Potential, and Limitations. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, Sayı: 29 Özel Sayı, 153–162. https://doi.org/10.38079/igusabder.1829028

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References (38)

  1. Liao Y, Deschamps F, Loures EFR, Ramos LFP. Past, present and future of Industry 4.0: A systematic literature review and research agenda proposal. Int J Prod Res. 2017;55(12):3609-3629.
  2. Pereira AC, Reis LP, Sousa P. Artificial intelligence and big data in nutrition and dietetics: Current applications and future perspectives. J Acad Nutr Diet. 2021;121(11):2267-2279.
  3. Russell S, Norvig P. Artificial Intelligence: A Modern Approach. 4th ed. Upper Saddle River, NJ: Pearson; 2022.
  4. Fuller A, Fan Z, Day C, Barlow C. Digital twin: Enabling technologies, challenges and open research. IEEE Access. 2020;8:108952-108971.
  5. Tudor BH, Shargo R, Gray GM, et al. A scoping review of human digital twins in healthcare applications and usage patterns. NPJ Digit Med. 2025;8:587.
  6. Mundt C, Yusufoğlu B, Kudenko D, et al. AI‐Driven personalized nutrition: Integrating omics, ethics, and digital health. Mol. Nutr. Food Res. 2025;69.
  7. Katsoulakis E, Wang Q, Wu H, et al. Digital twins for health: A scoping review. NPJ Digit Med. 2024;7:77.
  8. Gkouskou K, Vlastos I, Karkalousos P, et al. The “virtual digital twins” concept in precision nutrition. Adv Nutr. 2020;11(6):1405-1413.
  9. Joshi S, Shamanna P, Dharmalingam M, et al. Digital twin–enabled personalized nutrition improves metabolic dysfunction–associated fatty liver disease in type 2 diabetes: Results of a 1-year randomized controlled study. Endocr Pract. 2023;29(12):960-970.
  10. Shamanna P, Joshi S, Shah L, et al. Type 2 diabetes reversal with digital twin technology–enabled precision nutrition and staging of reversal: A retrospective cohort study. Clin Diabetes Endocrinol. 2021;7(1):21. doi:10.1186/s40842-021-00134-7
  11. Grieves M, Vickers J. Digital twin: Mitigating unpredictable, undesirable emergent behavior in complex systems. In: Kahlen FJ, Flumerfelt S, Alves A, eds. Transdisciplinary Perspectives on Complex Systems: New Findings and Approaches. Cham, Switzerland: Springer; 2017:85-113.
  12. Venkatesh KP, Brito G, Kamel Boulos MN. Health digital twins in life science and health care innovation. Annu Rev Pharmacol Toxicol. 2024;64:159-170.
  13. Ringeval M, Etindele Sosso FA, Cousineau M, Paré G. Advancing health care with digital twins: Meta-review of applications and implementation challenges. J Med Internet Res. 2025;27:e69544.
  14. National Academies of Sciences, Engineering, and Medicine. Foundational Research Gaps and Future Directions for Digital Twins. Washington, DC: National Academies Press; 2024. doi:10.17226/26894
  15. Jones D, Snider C, Nassehi A, Yon J, Hicks B. Characterising the digital twin: A systematic literature review. CIRP J Manuf Sci Technol. 2020;29:36-52.
  16. Lv Z, Xie S. Artificial intelligence in the digital twins: State of the art, challenges, and future research topics. Digit Twin. 2022;1(1). doi:10.12688/digitaltwin.17524.2
  17. Çelik BG, Attaran M. Digital twin: Benefits, use cases, challenges, and opportunities. Decis Anal J. 2023;6:100165.
  18. Croatti A, Gabellini M, Montagna S, Ricci A. On the integration of agents and digital twins in healthcare. J Med Syst. 2020;44:161-168.
  19. Armeni P, Polat I, De Rossi LM, Diaferia L, Meregalli S, Gatti A. Digital twins in healthcare: Is it the beginning of a new era of evidence-based medicine? A critical review. J Pers Med. 2022;12(8):1255.
  20. Elkefi S, Asan O. Digital twins for managing health care systems: Rapid literature review. J Med Internet Res. 2022;24(8):e37641.
  21. Fischer RP, Volpert A, Antonino P, Ahrens TD. Digital patient twins for personalized therapeutics and pharmaceutical manufacturing. Front Digit Health. 2024;5:1302338.
  22. Zhang K, Zhou HY, Baptista-Hon DT, et al; International Consortium of Digital Twins in Medicine. Concepts and applications of digital twins in healthcare and medicine. Patterns. 2024;5(8):101028.
  23. Dumas M, Fay AF, Charpentier E, Matricon J. Le jumeau numérique en santé: État des lieux et perspectives d’application à l’hôpital. Med Sci (Paris). 2023;39(12):953-957.
  24. Abrahams M. Digital twins: The future of personalized nutrition and health? Lifestyle Genomics. 2025;18(1):59-63.
  25. Wang Y, Lu CD, Chen W, Wang Q, Jiang H. Digital twin–enabled personalized nutrition. Precis Nutr. 2023;2(1):e00030.
  26. Kubínová J, Přibyl J, Mach M. Personalized nutrition and digital twins of food. Potravin Slovak J Food Sci. 2020;14(1):1130-1136.
  27. Zhu C, Bornhorst GM. Computational modeling of food digestion and bioaccessibility: Toward digital twins of food. Food Funct. 2021;12(8):3434-3453.
  28. Liu X, Bornhorst GM. Mechanistic modeling of food digestion: Designing foods with predictable digestive behavior. Annu Rev Food Sci Technol. 2022;13:229-252.
  29. Mathers JC. Personalised nutrition: Key concepts and current practice. Annu Rev Nutr. 2019;39:395-416.
  30. Arshad MT, Ali MKM, Maqsood S, et al. Personalized nutrition in the era of digital health: A new frontier for managing diabetes and obesity. Food Sci Nutr. 2025;13(10):e71006.
  31. Mosquera-Lopez C, Jacobs PG. Digital twins and artificial intelligence in metabolic disease research. Trends Endocrinol Metab. 2024;35(6):549-557.
  32. Shamanna P, Joshi S, Thajudeen M, et al. Personalized nutrition in type 2 diabetes remission: Application of digital twin technology for predictive glycemic control. Front Endocrinol. 2024;15:1485464.
  33. Silfvergren O, Simonsson C, Ekstedt M, Lundberg P, Gennemark P, Cedersund G. Digital twin predicting diet response before and after long-term fasting. PLoS Comput Biol. 2022;18(9):e1010469.
  34. Zhao J, Ghallab A, Hassan R, Dooley S, Hengstler JG, Drasdo D. A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage. iScience. 2023;27(2):108077.
  35. Magnúsdóttir S, Thiele I, Heinken A, et al. Building personalized gut microbiome metabolic models to predict short-chain fatty acid production in response to diet. Nat Microbiol. 2022;7(9):1355-1370.
  36. Vallée A. Digital twin for healthcare systems. Front Digit Health. 2023;5:1253050.
  37. Benson M. Digital twins for predictive, preventive, personalized, and participatory treatment of immune-mediated diseases. Arterioscler Thromb Vasc Biol. 2023;43(3):410-416.
  38. Iliuţă ME, Moisescu MA, Pop E, Ionita AD, Caramihai SI, Mitulescu TC. Digital twin: A review of the evolution from concept to technology and its analytical perspectives on applications in various fields. Appl Sci. 2024;14:5454.