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Journals / Güncel Pediatri / 2026 / Cilt: 17 Sayı: 2

Insulin-Like Growth Factor-1 and Morbidities of Prematurity: Bronchopulmonary Dysplasia, Retinopathy of Prematurity, Intraventricular Hemorrhage and Necrotizing Enterocolitis

İnsülin Benzeri Büyüme Faktörü-1 ve Premature Morbiditeleri: Bronkopulmoner Displazi, Premature Retinopatisi, İntraventriküler Kanama ve Nekrotizan Enterokolit

Bayram Ali Dorum0000-0002-2823-8454
Nilgün Köksal
Hilal Özkan
Salih Çağrı Çakır
Cansu Yılmaz
Taner Özgür
Ferah Budak
Pages
189–199
Publication Date
2019-08-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

DISCUSSION and CONCLUSION: Strong correlations have been found between low serum IGF-1 levels during the first four weeks and development of BPD and ROP.

📌 3 Key Takeaways

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Objective & Hypothesis:Insulin-like growth factor-1 (IGF-1) is important for fetal and postnatal development.
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Key Findings & Data:After premature births, serum IGF-1 concentrations rapidly decrease and can stay at much lower levels than during the intrauterine period.
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Conclusion & Impact:DISCUSSION and CONCLUSION: Strong correlations have been found between low serum IGF-1 levels during the first four weeks and development of BPD and ROP.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Bronkopulmoner displazi · insülin benzeri büyüme faktörü-1 · prematüre

Abstract

Insulin-like growth factor-1 (IGF-1) is important for fetal and postnatal development. After premature births, serum IGF-1 concentrations rapidly decrease and can stay at much lower levels than during the intrauterine period. In this study, we aimed to ascertain whether IGF-1 is associated with morbidities of prematurity such as bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), and necrotizing enterocolitis (NEC), and is a useful predictor of these diseases. METHODS: We enrolled newborn infants born at a postmenstrual age of ≤32 weeks in this prospective observational cohort study. Serum IGF-1 levels were measured serially in blood samples on the 1st, 3rd, 7th, 21st, and 28th day. RESULTS: A total of 93 infants were enrolled in the study. All these infants had the following characteristics at birth: weight 1236.11±354.06 g, and gestational age 29.43±2.10 weeks. All of the IGF-1 levels were significantly lower in the group which developed BPD or ROP (p<0.001). The patients who developed IVH and NEC also had lower IGF-1 levels. DISCUSSION and CONCLUSION: Strong correlations have been found between low serum IGF-1 levels during the first four weeks and development of BPD and ROP.

Özet

GİRİŞ ve AMAÇ: İnsulin benzeri büyüme faktörü-1 (IGF-1) fetal ve postnatal dönemde etkili önemli bir büyüme faktörüdür. Prematüre doğum sonrası serum IGF-1 düzeyleri hızlıca düşmekte intrauterin dönemden daha da düşük seviyelerde kalabilmektedir. Bu çalışmada serum IGF-1 düzeylerinin, bronkopulmoner displazi (BPD), prematüre retinopatisi (PR), intraventriküler kanama (İVK) ve nekrotizan enterokolit (NEK) gibi prematüre morbiditeleri ile ilişkisinin olup olmadığı ve morbiditeleri ön görmede belirteç olarak kullanıp kullanılamayacağı araştırılmıştır.

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Cite This Article

Dorum, B. A., Köksal, N., Özkan, H., Çakır, S. Ç., Yılmaz, C., Özgür, T., Budak, F. (2019). Insulin-Like Growth Factor-1 and Morbidities of Prematurity: Bronchopulmonary Dysplasia, Retinopathy of Prematurity, Intraventricular Hemorrhage and Necrotizing Enterocolitis. Güncel Pediatri, Cilt: 17 Sayı: 2, 189–199. https://ajindex.com/articles/1400880

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