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Journals / Erciyes Üniversitesi Veteriner Fakültesi Dergisi / 2026 / Cilt: 13 Sayı: 2

Effects of Pomegranate Seed Oil on Pentachlorophenol Toxicity Lipid Peroxidation and Some Biochemical Parameters in Rats

Ratlarda Pentaklorofenol Zehirlenmesinde Nar Çekirdeği Yağının Lipid Peroksidasyonu ve Biyokimyasal Parametrelere Etkileri

Zeynep Soyer Sarıca(ERCİYES ÜNİVERSİTESİ)
Bilal Cem Liman(ERCİYES ÜNİVERSİTESİ)
Pages
109–119
Publication Date
2016-08-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, it’s determined that pomegranate seed oil prevents the negative effects of the pentachlorophenol.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In the study, Sprague-Dawley male rats were used and four groups were formed.
📊
Key Findings & Data:The second group was given 0.15 ml/kg pomegranate seed oil (PSO), the third group was given 40mg/kg pentachlorphenol (PCP) and, the forth group was given 40mg/kg PCP+0.15 ml/kg PSO during 28 days as specified into stomach by gavages.
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Conclusion & Impact:Overall, it’s determined that pomegranate seed oil prevents the negative effects of the pentachlorophenol.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Lipid peroksidasyon · nar çekirdeği yağı · pentaklorofenol

Abstract

In the study, Sprague-Dawley male rats were used and four groups were formed. The first group was held as the control group. The second group was given 0.15 ml/kg pomegranate seed oil (PSO), the third group was given 40mg/kg pentachlorphenol (PCP) and, the forth group was given 40mg/kg PCP+0.15 ml/kg PSO during 28 days as specified into stomach by gavages. At the end of the experiment, erythrocyte haemoglobin, catalase, glutathione peroxidase, nitric oxide, blood serum 8-hidroksi-2-deoksi guanosin (8-OH-dG) and biochemical parameters were analysed. As a result, 40mg/kg PCP applied by gavage, caused liver damage, lipid peroxidation and decreased the anti-oxidant enzyme activity and 0.15ml/kg PSD applied for 28 days, had no negative effect on protein, oil and carbonhidrate metabolism, had no toxic effect on liver and had no effect on lipid peroxidation. Overall, it’s determined that pomegranate seed oil prevents the negative effects of the pentachlorophenol.

Özet

Çalışma Sprague-Dawley ırkı erkek sıçanlarda yapıldı. Çalışmada ilki kontrol olmak üzere 4 grup oluşturuldu. İkinci gruba 0.15ml/kg dozunda nar çekirdeği yağı (NÇY), üçüncü gruba 40mg/kg dozunda pentaklorofenol (PCP) ve dördüncü gruba 40mg/kg dozunda PCP+0.15ml/kg dozunda NÇY 28 gün boyunca gavaj ile uygulandı. Deneme sonunda eritrositte hemoglobin, katalaz ve glutasyon peroksidaz, nitrik oksit, malondialdehit, süperoksit dismutaz parametreleri; serumda 8-hidroksi-2-deoksi guanosin (8-OH-dG) ve biyokimyasal parametreleri incelendi. Sonuç olarak, bu çalışmada sıçanlara oral yoldan gavaj ile 40mg/kg uygulanan PCP’nin karaciğer hasarına, lipid peroksidasyonuna ve antioksidan enzim etkinliklerinde azalmaya yol açtığı; NÇY’nin PCP’nin istenmeyen etkileri üzerine koruyucu rolü olduğu belirlendi.

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Cite This Article

Sarıca, Z. S., Liman, B. C. (2016). Effects of Pomegranate Seed Oil on Pentachlorophenol Toxicity Lipid Peroxidation and Some Biochemical Parameters in Rats. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 13 Sayı: 2, 109–119. https://ajindex.com/articles/1391455

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