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Journals / Bozok Tıp Dergisi / 2026 / Cilt: 15 Sayı: 2

Evaluation of Thyroid Disorders in Effectively Treated Acromegalic Patients

Etkili Tedavi Edilmiş Akromegali Hastalarında Tiroid Bozuklarının Değerlendirilmesi

Abdullatif Sirin(DÜZCE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4001-9887
Osman Köstek(ISTANBUL MEDIPOL UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, MEDICAL ONCOLOGY)0000-0002-1901-5603
Mümtaz Takır(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-4363-3193
Mehmet Uzunlulu(ISTANBUL MEDENIYET UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8754-1069
Pages
119–124
Publication Date
2025-06-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Well control of disease may reduce the prevelance of thyroid cancer and risky nodules. acromegaly, thyroid disease, thyroid nodule

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract Objective: Acromegaly patients often develop goiter and thyroid nodules due to continuous stimulation of the thyroid follicle by growth hormon (GH) and insulin-like growth factor-1 (IGF-1).
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Key Findings & Data:Recent studies suggest a decrease in thyroid disease rates in patients who have been successfully treated.
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Conclusion & Impact:Well control of disease may reduce the prevelance of thyroid cancer and risky nodules. acromegaly, thyroid disease, thyroid nodule
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:akromegali · tiroid hastalıkları · tiroid nodülü

Abstract

Abstract Objective: Acromegaly patients often develop goiter and thyroid nodules due to continuous stimulation of the thyroid follicle by growth hormon (GH) and insulin-like growth factor-1 (IGF-1). Recent studies suggest a decrease in thyroid disease rates in patients who have been successfully treated. This study aimed to investigate thyroid disorders in patients who had cured or controlled the disease. Material and Methods: The patients’ GH levels less than 1 ng/mL and IGF-1 levels within the age-sex-adjusted normal range were categorized into controlled patients. Sonographic and biochemical findings of the thyroid gland were recorded. Results: The study included 33 patients with acromegaly (14 males and 19 females) and 50 volunteers (14 males and 36 females). The prevalence of goiter was higher in patients with acromegaly compared to control group (21.2% vs. 6%, respectively; p<0.001). Acromegaly patients had a higher frequency of thyroid nodules, but nodules larger than 1 cm were similar between the two groups. Conclusion: Acromegaly patients still have a high multinodular goiter incidence. Well control of disease may reduce the prevelance of thyroid cancer and risky nodules. acromegaly, thyroid disease, thyroid nodule

Özet

Giriş: Tiroid foliküllerinin growth hormon (GH) ve insülin-like growth faktör-1 (IGF-1) aracılığıyla sürekli uyarılması akromegali hastalarında guatr ve tiroid nodüllerinin gelişmesine neden olur. Güncel çalışmalar, başarılı şekilde tedavi edilen hastalarda tiroid hastalığı sıklığının azaldığını ileri sürmektedir. Bu çalışma, kür veya kontrol altına alınmış hastalardaki tiroid bozukluklarını araştırmak için yapılmıştır. Gereç ve Yöntemler: GH düzeyleri 1ng/mL’den düşük ve IGF-1 seviyeleri yaşa ve cinsiyete göre normal aralıkta olan hastalar kontrol altına alınmış hastalar olarak kategorize edildi. Tiroid bezinin sonografik ve biyokimyasal bulguları kaydedildi. Bulgular: Çalışmada 33 akromegali hastası (14 erkek ve 19 kadın) ve 50 gönüllü yer aldı. (14 erkekve 36 kadın). Akromegali hastalarındaki guatr sıklığı kontrol grubuna kıyasla daha fazla idi (sırasıyla, 21.2% ve 6%, p<0.001). Akromegali hastalarında tiroid nodülü daha sık görülmekle beraber 1 cm'den büyük nodül sıklığı iki grup arasında benzerdi. Sonuç: Akromegali hastalarında multinodüler guatr sıklığı halen yüksektir. Hastalığın tam kontrol altına alınması tiroid kanseri ve riskli nodül sıklığını azaltabilir.

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Cite This Article

Sirin, A., Köstek, O., Takır, M., Uzunlulu, M. (2025). Evaluation of Thyroid Disorders in Effectively Treated Acromegalic Patients. Bozok Tıp Dergisi, Cilt: 15 Sayı: 2, 119–124. https://doi.org/10.16919/bozoktip.1523690

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