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Journals / Bozok Tıp Dergisi / 2025 / Cilt: 15 Sayı: 4

Changes in Serum Nitric Oxide Levels in COVID-19 Patients

COVID-19 Hastalarında Serum Nitrik Oksit Düzeylerindeki Değişiklikler

Özge Nur Türkeri(ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ)0000-0001-8791-5331
Nezahat Kurt(ERZINCAN BINALI YILDIRIM UNIVERSITY)0000-0002-1685-5332
Fatma Betül Özgeriş(ATATURK UNIVERSITY)0000-0002-4568-5782
Ömer Faruk Koçak(ATATURK UNIVERSITY)0000-0001-5873-0944
Ebubekir Bakan(AGRI IBRAHIM CECEN UNIVERSITY)0000-0002-6390-9954
Emine Parlak(ATATURK UNIVERSITY)0000-0001-8912-6360
Pages
382–387
Publication Date
2025-12-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Variability in NO levels suggests that it may occur as a result of immune-inflammation and vascular dysfunction in COVID-19 patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The etiological agent of the COVID-19 pandemic, which has rapidly negatively affected the whole world in terms of both health and economy, is Coronavirus 2 (SARS-CoV-2), a member of the beta coronavirus family.
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Key Findings & Data:Although oxidative stress imbalance occurs in COVID-19 patients, how altered nitric oxide (NO) levels affect COVID-19 pathogenesis is not fully understood.
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Conclusion & Impact:Conclusion: Variability in NO levels suggests that it may occur as a result of immune-inflammation and vascular dysfunction in COVID-19 patients.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:COVID-19 · Serbest Radikal · Nitrik Oksit

Abstract

Aim: The etiological agent of the COVID-19 pandemic, which has rapidly negatively affected the whole world in terms of both health and economy, is Coronavirus 2 (SARS-CoV-2), a member of the beta coronavirus family. Although oxidative stress imbalance occurs in COVID-19 patients, how altered nitric oxide (NO) levels affect COVID-19 pathogenesis is not fully understood. For this purpose, NO levels were evaluated in COVID-19 patient serum sampels. Materials and Methods: A total of 50 adult COVID-19 patients and 32 healthy control individuals were included in the study. COVID-19 patients were classified as Mild-COVID-19, Modarete-COVID-19 and ICU-COVID-19 according to national guidelines. NO concentrations were measured spectrophotometrically from the serum samples of all patients. Additionally, biochemical data were collected. Results: As a result, NO levels were lower in the patient group compared to the control group, but this decrease was not statistically significant (p>0.05). Conclusion: Variability in NO levels suggests that it may occur as a result of immune-inflammation and vascular dysfunction in COVID-19 patients.

Özet

Amaç: Tüm dünyayı gerek sağlık gerekse ekonomik açıdan hızla olumsuz etkileyen COVID-19 pandemisinin etyolojik ajanı Coronavirüs 2 (SARS-CoV-2), beta koronavirüs ailesindendir. COVID-19 hastalarında oksidatif stres dengesizliği meydana gelmesine rağmen, değişen nitrik oksit (NO) seviyelerinin COVID-19 patogenezini nasıl etkilediği tam olarak anlaşılmamıştır. Bu amaçla COVID-19 hasta serumlarında NO düzeyleri değerlendirildi. Gereç ve Yöntem: Çalışmaya toplam 50 yetişkin COVID-19 hastası ve 32 sağlıklı kontrol birey dahil edildi. COVID-19 hastaları ulusal kılavuzlara göre Hafif-COVID-19, Orta-COVID-19 ve Yoğun Bakım-COVID-19 olmak üzere sınıflandırıldı. Tüm hastaların serum örneklerinden NO konsantrasyonları spektrofotometrik olarak ölçüldü. Ek olarak biyokimyasal verileri toplandı. Bulgular: Sonuç olarak NO düzeyleri hasta grupta kontrol grubuna göre düşüktü fakat bu düşüklük istatistiksel olarak anlamlı değildi (p>0.05). Sonuç: NO düzeylerindeki değişkenlik COVID-19 hastalarında immün inflamasyon ve vasküler disfonksiyonun bir sonucu olarak ortaya çıkabileceğini düşündürtmektedir.

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Cite This Article

Türkeri, Ö. N., Kurt, N., Özgeriş, F. B., Koçak, Ö. F., Bakan, E., Parlak, E. (2025). Changes in Serum Nitric Oxide Levels in COVID-19 Patients. Bozok Tıp Dergisi, Cilt: 15 Sayı: 4, 382–387. https://doi.org/10.16919/bozoktip.1612733

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