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Journals / Bozok Tıp Dergisi / 2026 / Cilt: 16 Sayı: 1

Frequency of Epstein Barr Virus Positivity in Gastric Cancer and Adjacent Non-Tumoral Epithelium

Mide Kanseri ve Komşu Non-Tümoral Epitelde Epstein Barr Virüsü Pozitifliğinin Sıklığı

Abdulkadir Yasir Bahar(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6963-3389
Seda Keskin Gökmen(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8379-3429
Emine Kılınç(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1032-651X
Selin Fitnet Görücü(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-2885-293X
Özge Duymaz Gümüştaş(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7427-1650
Rabia Hurşitoğlu(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1476-9801
Pages
167–174
Publication Date
2026-03-15
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

EBV positivity is also present in inflammatory cells, intestinal metaplasia and normal tissues adjacent to gastric carcinoma tissue.

📌 3 Key Takeaways

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Objective & Hypothesis:Background Epstein-Barr virus –associated gastric cancer is one of four molecular subtypes defined by the Cancer Genome Atlas Program.
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Key Findings & Data:Materials and Methods EBV positivity was assessed by chromogenic EBER-ISH in tumor tissues of 101 patients who were diagnosed with gastric carcinoma and underwent gastrectomy in our center between January 2008 and August 2023.
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Conclusion & Impact:EBV positivity is also present in inflammatory cells, intestinal metaplasia and normal tissues adjacent to gastric carcinoma tissue.
🔬Design:Araştırma Makalesi
📍Scope:2008 Verileri
⚙️Variables:mide kanseri · EBER · tümör mikroçevresi

Abstract

Background Epstein-Barr virus –associated gastric cancer is one of four molecular subtypes defined by the Cancer Genome Atlas Program. Epstein-Barr virus –associated gastric cancer incidence has ethnic and geographical differences. The aims of the present study were to investigate the frequency of EBV in gastric cancer tissues and adjacent non-tumoral epithelium. Materials and Methods EBV positivity was assessed by chromogenic EBER-ISH in tumor tissues of 101 patients who were diagnosed with gastric carcinoma and underwent gastrectomy in our center between January 2008 and August 2023. The link between EBV incidence in gastric cancer, survival and clinicopathological prognostic factors was statistically assessed. Results EBV was positive in tumor tissue in 6 of 101 (%5,9) cases. In addition, positive staining was detected in intestinal metaplasia areas adjacent to the tumor in 10 cases (9.9%) and in normal gastric mucosa adjacent to the tumor in 13 cases (12.9%). All 6 cases with EBV- associated gastric cancer were male, 4 had diffuse histological type and 3 were histological grade 3, 4 had lymph node metastases and 2 had distant metastases. No statistically significant correlation was found between EBER positivity and clinicopathological prognostic factors, except for male gender (p= 0.021). There was no statistical correlation between EBV positivity and survival. Conclusion The frequency of EBV- associated gastric cancer was 5.9% in our center. EBV positivity is also present in inflammatory cells, intestinal metaplasia and normal tissues adjacent to gastric carcinoma tissue.

Özet

Amaç Epstein-Barr virüsüyle ilişkili mide kanseri, Kanser Genom Atlası Programı tarafından tanımlanan dört moleküler alt tipten biridir. Epstein-Barr virüsüyle ilişkili mide kanseri insidansı etnik ve coğrafi farklılıklar gösterir. Bu çalışmanın amacı mide kanseri dokularında ve bitişik tümör dışı epitelde EBV sıklığını araştırmaktır. Gereç ve Yöntemler EBV pozitifliği, Ocak 2008 ile Ağustos 2023 arasında merkezimizde mide karsinomu tanısı konulan ve gastrektomi geçiren 101 hastanın tümör dokularında kromojenik EBER-ISH ile değerlendirildi. Mide kanserinde EBV insidansı, sağ kalım ve klinikopatolojik prognostik faktörler arasındaki bağlantı istatistiksel olarak değerlendirildi. Sonuçlar EBV, 101 vakanın 6'sında (%5,9) tümör dokusunda pozitifti. Ek olarak, 10 vakada (%9,9) tümöre bitişik intestinal metaplazi alanlarında ve 13 vakada (%12,9) tümöre bitişik normal gastrik mukozada pozitif boyanma tespit edildi. EBV ile ilişkili gastrik kanserli 6 vakanın hepsi erkekti, 4'ü diffüz histolojik tipteydi ve 3'ü histolojik derece 3'tü, 4'ünde lenf nodu metastazı ve 2'sinde uzak metastaz vardı. Erkek cinsiyeti dışında (p= 0,021), EBER pozitifliği ile klinikopatolojik prognostik faktörler arasında istatistiksel olarak anlamlı korelasyon bulunmadı . EBV pozitifliği ile sağkalım arasında istatistiksel olarak anlamlı korelasyon bulunamadı. Sonuç Merkezimizde EBV ile ilişkili gastrik kanser sıklığı %5,9'dur.. EBV pozitifliği ayrıca inflamatuar hücrelerde, intestinal metaplazide ve gastrik karsinom dokusuna bitişik normal dokularda da mevcuttur.

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Cite This Article

Bahar, A. Y., Gökmen, S. K., Kılınç, E., Görücü, S. F., Gümüştaş, Ö. D., Hurşitoğlu, R. (2026). Frequency of Epstein Barr Virus Positivity in Gastric Cancer and Adjacent Non-Tumoral Epithelium. Bozok Tıp Dergisi, Cilt: 16 Sayı: 1, 167–174. https://doi.org/10.16919/bozoktip.1727058

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