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Journals / Bozok Tıp Dergisi / 2026 / Cilt: 16 Sayı: 2

EVALUATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN PATIENTS WITH NASAL SEPTUM DEVIATION AND TURBINATE HYPERTROPHY

Beyin Türevli Nörotrofik Faktör (BDNF) Seviyelerinin Nazal Septum Deviasyonu ve Konka Hipertrofisi Tanılı Hastalarda İncelenmesi

Ramazan Keleş(BOZOK ÜNİVERSİTESİ)0000-0003-4359-2790
Ayşe Yeşim Göçmen(BOZOK ÜNİVERSİTESİ)0000-0002-8511-639X
Hakan Dağıstan0000-0003-4717-5337
Pages
329–335
Publication Date
2026-06-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study is important as it represents the first investigation in the literature examining BDNF levels in this specific patient population.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Nasal obstruction is a common health problem in the general population.
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Key Findings & Data:Material and Methods: A total of 44 patients and 44 controls, aged between 18 and 55 years and without systemic diseases, who presented to the otorhinolaryngology outpatient clinic, were included in the study.
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Conclusion & Impact:This study is important as it represents the first investigation in the literature examining BDNF levels in this specific patient population.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Beyin Türevli Nörotrofik Faktör · Nazal Septum Deviasyonu · Konka Hipertrofisi

Abstract

Objective: Nasal obstruction is a common health problem in the general population. Its most frequent causes are nasal septal deviation (NSD) and turbinate hypertrophy (TH), which may lead to chronic hypoxia. The aim of this study was to determine serum brain-derived neurotrophic factor (BDNF) levels in patients diagnosed with NSD and TH and to investigate the effect of chronic hypoxia on BDNF. Material and Methods: A total of 44 patients and 44 controls, aged between 18 and 55 years and without systemic diseases, who presented to the otorhinolaryngology outpatient clinic, were included in the study. Blood samples obtained from the participants were centrifuged, and serum BDNF levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analyses were performed using SPSS version 23.0. Data distribution was assessed using the Shapiro-Wilk test. Normally distributed variables (serum BDNF levels) were analyzed using the independent samples t-test, whereas non-normally distributed variables (age) were analyzed using the Mann-Whitney U test. Results: Serum BDNF levels in the patient group (106.07±9.99 ng/mL) were found to be statistically significantly lower than those in the control group (114.62±8.42 ng/mL) (p:0.00004). BDNF levels did not show a significant correlation with participants' age or sex (p>0.05). Conclusion: Hypoxia resulting from NSD and TH adversely affects serum BDNF levels. Considering the roles of BDNF in neuronal survival and plasticity, individuals with nasal obstruction may be at risk for cognitive functional impairment. This study is important as it represents the first investigation in the literature examining BDNF levels in this specific patient population.

Özet

Amaç: Burun tıkanıklığı, toplumda yaygın görülen sağlık problemidir. En sık nedenleri nazal septum deviasyonu (NSD) ve konka hipertrofisi (KH)’dir ve sonucunda kronik hipoksi görülür. Çalışmanın amacı, NSD ve KH tanılı hastalarda serum beyin türevli nörotrofik faktör (BDNF) düzeylerini belirlemek ve kronik hipoksinin, BDNF üzerindeki etkisini araştırmaktır. Gereç ve Yöntemler: KBB polikliniğine başvuran, 18-55 yaş aralığında, sistemik hastalığı olmayan 44 hasta ve 44 kontrol grubu çalışmaya dahil edildi. Katılımcılardan alınan artık kan örnekleri santrifüj sonrası elde edilen serumlarda BDNF düzeyleri ELISA yöntemi ile analiz edildi. İstatistiksel değerlendirmeler SPSS 23.0 programı kullanılarak yapıldı. Veri dağılımı Shapiro-Wilk testi ile değerlendirildi; normal dağılım gösteren değişkenler (BDNF düzeyleri) bağımsız örneklem t-testi, normal dağılım göstermeyen değişkenler (yaş) ise Mann-Whitney U testi ile analiz edildi. Bulgular: Hasta grubunun serum BDNF düzeyleri (106,07±9,99 ng/ml), kontrol grubunun değerlerinden (114,62±8,42 ng/ml) istatistiksel olarak anlamlı derecede düşük saptandı (p:0.0004). Ayrıca, BDNF düzeylerinin katılımcıların yaşı veya cinsiyeti ile anlamlı bir korelasyon göstermediği belirlendi (p>0,05). Sonuç: NSD ve KH’ye bağlı gelişen hipoksinin serum BDNF düzeylerini olumsuz etkilediğini göstermektedir. BDNF’nin nöronal sağkalım ve plastiklik üzerindeki rolleri göz önüne alındığında, burun tıkanıklığı olan bireylerin bilişsel fonksiyon kayıpları açısından risk altında olabileceği değerlendirilmektedir. Bu çalışma, literatürde bu spesifik hasta grubunda BDNF düzeylerini inceleyen ilk araştırma olması bakımından önemlidir.

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Cite This Article

Keleş, R., Göçmen, A. Y., Dağıstan, H. (2026). EVALUATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN PATIENTS WITH NASAL SEPTUM DEVIATION AND TURBINATE HYPERTROPHY. Bozok Tıp Dergisi, Cilt: 16 Sayı: 2, 329–335. https://doi.org/10.16919/bozoktip.1922691

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