Journals / Bozok Tıp Dergisi / 2026 / Cilt: 16 Sayı: 2

OUTCOMES OF THE FIRST 100 ADRENALECTOMIES IN A SINGLE CENTER: RETROSPECTIVE COHORT STUDY

Tek Merkezde İlk 100 Adrenalektominin Sonuçları: Retrospektif Kohort Çalışması

Emre Hepşen(Ankara Etlik Şehir Hastanesi)0000-0002-4634-5114
Adem Sancı(Ankara Etlik Şehir Hastanesi)0000-0003-2229-8234
Metin Yığman(Ankara Etlik Şehir Hastanesi)0000-0003-1217-8458
Kubilay Sarıkaya(Ankara Etlik Şehir Hastanesi)0000-0003-1734-2392
Alper Gök(Ankara Etlik Şehir Hastanesi)0000-0001-6874-4151
Semih Yaşar Sargın(Ankara Etlik Şehir Hastanesi)0009-0002-1029-3989
Erman Çakal(Ankara Etlik Şehir Hastanesi)0000-0003-4455-7276
Pages
312–321
Publication Date
2026-06-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Surgical approach should be individualized according to tumor characteristics and suspected pathology.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to evaluate the first 100 adrenalectomy cases in our clinic by analyzing preoperative indications, perioperative outcomes, postoperative follow-up, and final histopathological findings.
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Key Findings & Data:Results: LA was attempted in 96 patients and completed in 94, with conversion to OA in 2 cases (2.1%).
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Conclusion & Impact:Surgical approach should be individualized according to tumor characteristics and suspected pathology.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Adrenal Tümör · Adrenalektomi · Laparoskopik Adrenalektomi

Abstract

Objective: We aimed to evaluate the first 100 adrenalectomy cases in our clinic by analyzing preoperative indications, perioperative outcomes, postoperative follow-up, and final histopathological findings. Material and Methods: This retrospective study included patients who underwent laparoscopic (LA) or open adrenalectomy (OA). Surgical indications were determined after multidisciplinary evaluation including endocrinology, based on clinical assessment, hormonal analyses, and imaging findings. Results: LA was attempted in 96 patients and completed in 94, with conversion to OA in 2 cases (2.1%). Among 34 patients with Cushing syndrome (CS), 33 had benign adenomas and one (2.9%) had adrenocortical carcinoma (ACC). Among 29 patients with primary aldosteronism (PA), 28 had adenomas and one (3.4%) was suspicious for ACC. Among 18 patients with suspected pheochromocytoma (Pheo), pathology confirmed Pheo in 16 patients; LA was completed in 15 cases. One patient with a 6-cm ACC underwent LA, whereas two patients with tumors measuring 9 cm and 18 cm underwent OA. Among four who underwent LA for suspicious lesions, three were benign and one had a 12-cm mature teratoma. Nine had adrenal cysts, and three were diagnosed with myelolipoma (ML). The largest adrenal mass resected laparoscopically was a 14-cm ML. Within hormonally active tumors, Pheo patients had larger tumors, longer operative time, higher intraoperative fluid aspiration, higher hemoglobin decrease, and longer drain removal time (p=0.007). OA cases had significantly larger tumors, higher-risk pathologies and worse perioperative outcomes compared with completed LA procedures. Antihypertensive requirements improved after adrenalectomy in hormonally active tumors: 77% in CS, 89.7% in PA, and 94.4% in Pheo. Conclusion: Adrenalectomy can be performed safely with appropriate patient selection and multidisciplinary management. Surgical approach should be individualized according to tumor characteristics and suspected pathology.

Özet

Amaç: Kliniğimizde gerçekleştirilen ilk 100 adrenalektomi olgusunu; preoperatif endikasyonlar, perioperatif sonuçlar, postoperatif takip bulguları ve histopatolojik sonuçlar açısından değerlendirilmesini amaçladık. Gereç ve Yöntemler: Retrospektif çalışmaya laparoskopik (LA) veya açık adrenalektomi (AA) uygulanan hastalar dahil edildi. Cerrahi endikasyonlar; klinik değerlendirme, hormonal analizler ve görüntüleme bulgularına dayanarak endokrinoloji ile multidisipliner konsey sonrası belirlendi. Bulgular: LA 96 hastaya başlandı ve 94’ünde tamamlandı; 2 olguda (%2,1) AA’ye konversiyon gerekti. Cushing sendromu (CS) tanılı 34 hastanın 33’ünde benign adenom, 1’inde (%2,9) adrenokortikal karsinom (ACC) saptandı. Primer aldosteronizm (PA) tanılı 29 hastanın 28’inde adenom, 1’inde (%3,4) ACC şüphesi mevcuttu. Feokromositoma (Pheo) ön tanısı ile opere edilen 18 hastanın 16’sında patoloji Pheo ile uyumlu bulundu; 15’inde laparoskopik cerrahi tamamlandı. 6 cm’lik ACC olgusu laparoskopik olarak tamamlanırken, 9 cm ve 18 cm tümörlü iki olguda AA tercih edildi. Şüpheli lezyon nedeniyle LA yapılan dört hastanın üçünde benign adenom, birinde 12 cm matür teratom saptandı. Dokuz hastada adrenal kist, üç hastada miyelolipom (ML) izlendi; LA yapılarak çıkarılan en büyük kitle 14 cm’lik ML idi. Hormonal aktif tümörler içinde Pheo grubunda tümör boyutu, operasyon süresi, aspire edilen sıvı miktarı, hemoglobin düşüşü ve dren çekilme süresi daha yüksekti (p=0.007). AA uygulanan hastalarda tümör boyutu daha büyük ve riskli patolojilerden oluşmakla birlikte perioperatif sonuçlar daha olumsuzdu. Antihipertansif gereksinimde düzelme CS’de %77, PA’da %89,7 ve Pheo’da %94,4 oranında saptandı. Sonuç: Uygun hasta seçimi ve multidisipliner yaklaşım ile adrenalektomi güvenle uygulanabilir. Cerrahi yöntem, tümör özellikleri ve olası patolojiye göre bireyselleştirilmelidir.

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Cite This Article

Hepşen, E., Sancı, A., Yığman, M., Sarıkaya, K., Gök, A., Sargın, S. Y., Çakal, E. (2026). OUTCOMES OF THE FIRST 100 ADRENALECTOMIES IN A SINGLE CENTER: RETROSPECTIVE COHORT STUDY. Bozok Tıp Dergisi, Cilt: 16 Sayı: 2, 312–321. https://doi.org/10.16919/bozoktip.1919564

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