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Journals / Black Sea Journal of Agriculture / 2026 / Cilt: 9 Sayı: 2

The Role of Placental Development in Determining Birth Weight and Growth Performance of Lambs

Doğan Türkyılmaz(ATATURK UNIVERSITY)0000-0001-6293-3787
Ülkü Dağdelen(ATATÜRK ÜNİVERSİTESİ)0000-0002-5167-8255
Pages
300–309
Publication Date
2026-03-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review highlights key knowledge gaps and emphasizes the need for standardized placental phenotyping and integrative research approaches to improve understanding of early-life determinants of growth performance in sheep.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The placenta plays a central role in regulating fetal growth and is a key determinant of lamb birth weight and postnatal growth performance.
📊
Key Findings & Data:In sheep, variation in placental traits influences not only neonatal outcomes but also subsequent growth trajectories, supporting the concept of developmental programming.
💡
Conclusion & Impact:This review highlights key knowledge gaps and emphasizes the need for standardized placental phenotyping and integrative research approaches to improve understanding of early-life determinants of growth performance in sheep.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Placenta · Placental efficiency · Cotyledon

Abstract

The placenta plays a central role in regulating fetal growth and is a key determinant of lamb birth weight and postnatal growth performance. In sheep, variation in placental traits influences not only neonatal outcomes but also subsequent growth trajectories, supporting the concept of developmental programming. This review summarizes current knowledge on major placental traits, including placental weight, cotyledon number, cotyledon size and surface area, and indices of placental efficiency, and evaluates their associations with lamb birth weight and postnatal growth. Evidence indicates that placental mass alone does not adequately reflect placental function, whereas cotyledon-based traits and placental efficiency provide more informative indicators of fetal growth capacity. Relationships between placental traits and growth outcomes are strongly influenced by litter size, dam parity, and breed. This review highlights key knowledge gaps and emphasizes the need for standardized placental phenotyping and integrative research approaches to improve understanding of early-life determinants of growth performance in sheep.

Özet

The placenta plays a central role in regulating fetal growth and is a key determinant of lamb birth weight and postnatal growth performance. In sheep, variation in placental traits influences not only neonatal outcomes but also subsequent growth trajectories, supporting the concept of developmental programming. This review summarizes current knowledge on major placental traits, including placental weight, cotyledon number, cotyledon size and surface area, and indices of placental efficiency, and evaluates their associations with lamb birth weight and postnatal growth. Evidence indicates that placental mass alone does not adequately reflect placental function, whereas cotyledon-based traits and placental efficiency provide more informative indicators of fetal growth capacity. Relationships between placental traits and growth outcomes are strongly influenced by litter size, dam parity, and breed. This review highlights key knowledge gaps and emphasizes the need for standardized placental phenotyping and integrative research approaches to improve understanding of early-life determinants of growth performance in sheep.

🔖

Cite This Article

Türkyılmaz, D., Dağdelen, Ü. (2026). The Role of Placental Development in Determining Birth Weight and Growth Performance of Lambs. Black Sea Journal of Agriculture, Cilt: 9 Sayı: 2, 300–309. https://doi.org/10.47115/bsagriculture.1842470

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References (40)

  1. Ashley, R. L., Trigo, E. M., & Ervin, J. M. (2023). Placental insufficiency and heavier placentas in sheep after suppressing CXCL12/CXCR4 signaling during implantation. Biology of Reproduction, 109(6), 982-993, https://doi.org/10.1093/biolre/ioad122
  2. Barker, D. J. P. (2007). The origins of the developmental origins theory. Journal of Internal Medicine, 261, 412–417, https://doi.org/10.1111/j.1365-2796.2007.01809.x
  3. Dagdelen, U., & Esenbuga, N. (2025). Association of GH/HaeIII polymorphism with growth and developmental traits of Morkaraman sheep. Archives Animal Breeding, 68(3), 575-587, https://doi.org/10.5194/aab-68-575-2025
  4. Dwyer, C. M. (2008). The welfare of the neonatal lamb. Small Ruminant Research, 62, 15–28. https://doi.org/10.1016/j.smallrumres.2007.12.011
  5. Gordon, I. (2003). Laboratory Production of Cattle Embryos. CABI Publishing, Cambridge, UK, 548 pp.
  6. Greenwood, P. L., Hunt, A. S., Hermanson, J. W., & Bell, A. W. (2000). Effects of birth weight and postnatal nutrition on neonatal sheep. Journal of Animal Science, 88, 364–375. https://doi.org/10.2527/2000.78150x
  7. Igwebuike, U. M. (2010). Impact of maternal nutrition on ovine foetoplacental development: A review of the role of insulin-like growth factors. Animal Reproduction Science, 121(3–4), 189–196, https://doi.org/10.1016/j.anireprosci.2010.04.007
  8. Iwasaki, S., Yoshiba, N., Ushijima, H., Watanabe, S., & Nakahara, T. (1990). Morphology and proportion of inner cell mass of bovine blastocysts fertilized in vitro and in vivo. Journal of Reproduction and Fertility, 90(1), 279–284, https://doi.org/10.1530/jrf.0.0900279
  9. Kaşıkçı, G., Yılmaz, Ö., Gündüz, M. C. & Kırşan, İ., 2011. Comparison of placentome diameters in single and twin-pregnant sheep by ultrasonographic method. Turkish Journal of Veterinary & Animal Sciences, 35(3), 187-191, https://doi.org/10.3906/vet-1010-517
  10. Kaur, P., Verma, N., Wadhawan, A., Garg, P., Ralmilay, S., Kalra, N.,. & Singh, V. (2025). Insulin-like growth factor-1 levels reflect muscle and bone health and determine complications and mortality in decompensated cirrhosis. Journal of Clinical and Experimental Hepatology, 15(1), 102402, https://doi.org/10.1016/j.jceh.2024.102402
  11. Kenyon, P. R., Maloney, S. K., & Blache, D. (2014). Review of sheep body condition score in relation to production characteristics. New Zealand Journal of Agricultural Research, 57, 38-64, https://doi.org/10.1080/00288233.2013.857698
  12. Konyalı, A., Tölü, C., & Savaş, T. (2004a). Bazı doğum özelliklerinin oğlaklarda büyüme üzerine etkileri. IV. Ulusal Zootekni Kongresi, Isparta, Türkiye.
  13. Konyalı, A., Tölü, C., Daş, G., Göncü, C., & Savaş, T. (2004b). Keçilerde doğum ve davranışlarına ilişkin bir araştırma. Ankara Üniversitesi Ziraat Fakültesi Tarım Bilimleri Dergisi, 10, 397–401.
  14. Konyalı, A., Tölü, C., Daş, G., & Savaş, T. (2006). Birth and neonatal behaviour and their effects on growth of Turkish Saanen kids. Züchtungskunde, 78(3), 230–240.
  15. Konyalı, A., Tölü, C., Daş, G., & Savaş, T. (2007). Factors affecting placental traits and relationships of placental traits with neonatal behavior in goats. Animal Reproduction Science, 97(3–4), 387–394, https://doi.org/10.1016/j.anireprosci.2006.09.008
  16. Konyalı, A., Tölü, C., Ayağ, B. S., & Akbağ, H. I. (2011). Observations on hand-mating behaviors and selected physiological and hematological parameters in Turkish dairy goats. Animal Science Journal, 82(2), 251–258, https://doi.org/10.1111/j.1740-0929.2010.00851.x
  17. Lacroix, M. C., Bolifraud, P., Durieux, D., Pauloin, A., Vidaud, M., & Kann, G. (2002). Placental growth hormone and lactogen production by perifused ovine placental explants: Regulation by growth hormone-releasing hormone and glucose. Biology of Reproduction, 66, 555–561, https://doi.org/10.1095/ biolreprod66.3.555
  18. Lee, C. S., Wooding, F. B. P., & Morgan, G. (1997). Quantitative analysis throughout pregnancy of intraepithelial large granular and nongranular lymphocyte distributions in the synepitheliochorial placenta of the cow. Placenta, 18, 675–681, https://doi.org/10.1016/S0143-4004(97)90009-6
  19. Ozyurek, S., & Turkyilmaz, D. (2020). Determination of relationships between placental characteristics and birth weight in Morkaraman sheep. Archives Animal Breeding, 63(1), 39-44, https://doi.org/10.5194/aab-63-39-2020
  20. Redmer, D. A., Wallace, J. M., & Reynolds, L. P. (2004). Effect of nutrient intake during pregnancy on fetal growth and vascular development. Domestic Animal Endocrinology, 27, 199–217, https://doi.org/10.1016/j.domaniend.2004.06.006
  21. Reynolds, L. P., & Redmer, D. A. (2001). Angiogenesis in the placenta. Biology of Reproduction, 64, 1033–1040, https://doi.org/10.1095/biolreprod64.4.1033
  22. Reynolds, L. P., Borowicz, P. P., Caton, J. S., Vonnahme, K. A., Luther, J. S., Buchanan, D. S.,. & Redmer, D. A. (2010). Uteroplacental vascular development and placental function: an update. International Journal of Developmental Biology, 54(2), 355-365, https://doi.org/10.1387/ijdb.082799lr
  23. Reynolds, L. P., Dahlen, C. R., Ward, A. K., Crouse, M. S., Borowicz, P. P., Davila-Ruiz, B. J.,. & Caton, J. S. (2023). Role of the placenta in developmental programming: observations from models using large animals. Animal Reproduction Science, 257, 107322, https://doi.org/10.1016/j.anireprosci.2023.107322
  24. Sammin, D., Markey, B., Bassett, H., & Buxton, D. (2009). The ovine placenta and placentitis: A review. Veterinary Microbiology, 135(1–2), 90–97, https://doi.org/10.1016/j.vetmic.2008.09.054
  25. Sartori, E. D., Sessim, A. G., Brutti, D. D., Lopes, J. F., McManus, C. M., & Barcellos, J. O. (2020). Fetal programming in sheep: effects on pre-and postnatal development in lambs. Journal of Animal Science, 98(9), skaa294, https://doi.org/10.1093/jas/skaa294
  26. Sferruzzi-Perri, A. N., Sandovici, I., Constância, M., & Fowden, A. L. (2017). Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. The Journal of Physiology, 595(15), 5057-5093. https://doi.org/10.1113/JP273330
  27. Şen, U. (2021). The relationship between placental characteristics and lamb birth weight in Akkaraman Turkish native sheep breed. Large Animal Review, 27(4), 223-232.
  28. Toschi, P., & Baratta, M. (2021). Ruminant placental adaptation in early maternal undernutrition: An overview. Frontiers in Veterinary Science, 8, 755034, https://doi.org/10.3389/fvets.2021.755034
  29. Turkyilmaz, D., & Esenbuga, N. (2022). Improving the functional value of meat quality by feeding with protected fat supplementation in Morkaraman lambs. Archives of Animal Nutrition, 76(2), 145-158, https://doi.org/10.1080/1745039X.2022.2097825
  30. Vautier, A. N., & Cadaret, C. N. (2022). Long-term consequences of adaptive fetal programming in ruminant livestock. Frontiers in Animal Science, 3, 778440, https://doi.org/10.3389/fanim.2022.778440
  31. Vonnahme, K. A., Hess, B. W., Hansen, T. R., McCormick, R. J., Rule, D. C., Moss, G. E.,. & Ford, S. P. (2003). Maternal undernutrition from early-to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biology of Reproduction, 69(1), 133-140, https://doi.org/10.1095/biolreprod.102.012120
  32. Vonnahme, K. A., Arndt, W. J., Johnson, M. L., Borowicz, P. P., & Reynolds, L. P. (2008). Effect of morphology on placentome size, vascularity, and vasoreactivity in late pregnant sheep. Biology of Reproduction, 79(5), 976-982, https://doi.org/10.1095/biolreprod.108.070748
  33. Vonnahme, K. A. (2012). How the maternal environment impacts fetal and placental development: implications for livestock production. IV International Symposium on Animal Biology of Reproduction, (789-797). Animal Reproduction.
  34. Wooding, F. B. P., Morgan, G., & Adam, C. L. (1997). Structure and function in the ruminant synepitheliochorial placenta: central role of the trophoblast binucleate cell in deer. Microscopy Research and Technique, 38(1‐2), 88-99. https://doi.org/10.1002/(SICI)1097-0029(19970701/15)38:1/2%3C88::AID-JEMT10%3E3.0.CO;2-A
  35. Kaur, P., Verma, N., Wadhawan, A., Garg, P., Ralmilay, S., Kalra, N.,. & Singh, V. (2025). Insulin-like growth factor-1 levels reflect muscle and bone health and determine complications and mortality in decompensated cirrhosis. Journal of Clinical and Experimental Hepatology, 15(1), 102402, https://doi.org/10.1016/j.jceh.2024.102402
  36. Konyalı, A., Tölü, C., Daş, G., & Savaş, T. (2007). Factors affecting placental traits and relationships of placental traits with neonatal behavior in goats. Animal Reproduction Science, 97(3–4), 387–394, https://doi.org/10.1016/j.anireprosci.2006.09.008
  37. Reynolds, L. P., Borowicz, P. P., Caton, J. S., Vonnahme, K. A., Luther, J. S., Buchanan, D. S.,. & Redmer, D. A. (2010). Uteroplacental vascular development and placental function: an update. International Journal of Developmental Biology, 54(2), 355-365, https://doi.org/10.1387/ijdb.082799lr
  38. Reynolds, L. P., Dahlen, C. R., Ward, A. K., Crouse, M. S., Borowicz, P. P., Davila-Ruiz, B. J.,. & Caton, J. S. (2023). Role of the placenta in developmental programming: observations from models using large animals. Animal Reproduction Science, 257, 107322, https://doi.org/10.1016/j.anireprosci.2023.107322
  39. Sammin, D., Markey, B., Bassett, H., & Buxton, D. (2009). The ovine placenta and placentitis: A review. Veterinary Microbiology, 135(1–2), 90–97, https://doi.org/10.1016/j.vetmic.2008.09.054
  40. Vonnahme, K. A., Hess, B. W., Hansen, T. R., McCormick, R. J., Rule, D. C., Moss, G. E.,. & Ford, S. P. (2003). Maternal undernutrition from early-to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biology of Reproduction, 69(1), 133-140, https://doi.org/10.1095/biolreprod.102.012120