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Journals / Ankara Medical Journal / 2026 / Cilt: 19 Sayı: 3

Evaluation of Hematological Parameters and Iron Level in Obese Children and Adolescents

Obez Çocuk ve Adolesanlarda Hematolojik Parametreler ve Demir Düzeyinin Değerlendirilmesi

Cemile Ece Çağlar Şimşek
Nurullah Çelik
Utku Aygüneş
Amine Yavuz Dönmez
Ezgi Avcı
Mahmut Ekici
Pages
479–487
Publication Date
2019-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore ferritin level may be misled for investigating iron deficiency status in obese adolescents

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives : The aim of the study was to investigate hematological parameters and iron level in obese children and adolescents in different age groups.
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Key Findings & Data:Materials and Methods: The study population consisted of hundred-fifty four obese children and adolescents aged between 3 and 18 years, who were being followed at the Cumhuriyet University Faculty of Medicine Hospital, Pediatric Endocrinology Clinic.
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Conclusion & Impact:Therefore ferritin level may be misled for investigating iron deficiency status in obese adolescents
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Çocuklar · obezite · demir eksikliği

Abstract

Objectives : The aim of the study was to investigate hematological parameters and iron level in obese children and adolescents in different age groups. Materials and Methods: The study population consisted of hundred-fifty four obese children and adolescents aged between 3 and 18 years, who were being followed at the Cumhuriyet University Faculty of Medicine Hospital, Pediatric Endocrinology Clinic. As the control group, 158 healthy age and sex-matched children were also included. The children were divided into three groups according to age: Group 1 (3-7 years), Group 2 (7-12 years), and Group 3 (12-18 years). Hematological parameters, serum iron, total iron-binding capacity, and ferritin levels were compared, and their correlations with body mass index(BMI) were investigated. Results: The mean ages of the control (10,66±3,40; %55,80 girls) and case (10± 4,16; %62 girls) groups were similar. When compared serum iron, total iron-binding capacity, transferrin saturation and ferritin levels, in obese children aged between 12-18 years, serum iron and transferrin saturation was lower whereas ferritin level and total iron-binding capacity were higher (p<0,001). On the other hand, the ferritin level and total iron-binding capacity were higher in obese children aged between 7-12 years, while the other parameters were similar. When the correlations between BMI-SDS and hematological parameters were evaluated; positive correlations with white blood cell count (r = 0.46, p< 0.001), absolute neutrophil count (r = 0.40, p< 0.001) and ferritin levels (r = 0.36, P <0.001), while a negative correlation with transferrin saturation percentage (r = -0.22, p = 0.02) were found. Conclusion : Obese adolescents are prone to iron deficiency with low saturation index. Therefore ferritin level may be misled for investigating iron deficiency status in obese adolescents

Özet

Amaç : Bu çalışmanın amacı farklı yaş gruplarındaki obez çocuk ve adolesanlarda hematolojik parametreler ve demir düzeylerini araştırmaktır. Materyal ve Metot: Bu çalışmaya Cumhuriyet Üniversitesi Tıp Fakültesi, Çocuk Endokrinoloji Polikliniğinde takip edilen, 3-18 yaş arası yüz ellidört çocuk ve adolesan dahil edilmiştir. Kontrol grubu olarak ise, yaş ve cinsiyetleri benzer, sağlıklı 158 çocuk alınmıştır. Çocuklar yaş gruplarına göre, Grup 1 (3-7 yaş), Grup 2 (7-12 yaş) ve Grup 3 (12-18 yaş) olmak üzere 3’e ayrıldı. Hematolojik parametreler, serum demir, demir bağlama kapasitesi(FeBK) ve ferritin düzeyleri karşılaştırıldı, Vücut Kitle İndeksi(VKI) ile olan korelasyonları araştırıldı. Bulgular : Kontrol (10,66±3,40; %55,8 kız) ve vaka (10± 4,16; %62 kız) gruplarında yaş ortalamalrı benzerdi. Serum demir, FeBK, transferrin saturasyonu ve ferritin düzeyleri karşılaştırıldığında ise 12-18 yaş grubunda, obez çocuklarda, serum demiri ve transferrin saturasyonu daha düşükken, ferritin düzeyi ve FeBK daha yüksekti (p<0,001). 7-12 yaş grubunda ise obez çocuklarda ferritin düzeyi ve FeBK daha yüksekken diğer parametreler benzerdi. Vücut kitle indeksi standart sapma (VKI-SDS) ile hematolojik parametrelerin korelasyonları karşılaştırıldığında, VKI-SDS Beyaz Küre Sayısı (r=0,46, p<0,001), Absolü Nötrofil Sayısı (r=0,40, p<0.001) ve Ferritin (r=0,36, p<0,001) ile pozitif korelasyon gösterirken, Transferrin Saturasyon Yüzdesi ile negatif bir korelasyon ( r=-0,22, p=0,02 ) gösteriyordu. Sonuç : Obez adolesanlar düşük saturasyon indeksi nedeni ile demir eksikliğine yatkındırlar. Obezlerde demir durumu araştırılırken ferritin düzeyi tek başına yanıltıcı olabilir.

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Cite This Article

Şimşek, C. E. Ç., Çelik, N., Aygüneş, U., Dönmez, A. Y., Avcı, E., Ekici, M. (2019). Evaluation of Hematological Parameters and Iron Level in Obese Children and Adolescents. Ankara Medical Journal, Cilt: 19 Sayı: 3, 479–487. https://doi.org/10.17098/amj.624400

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