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Journals / Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2026 / Cilt: 51 Sayı: 2

The Effects of Isotretinoin on Menstrual Cycle and Hormone Levels

İzotretinoinin Serum Hormonları ve Menstrüel Siklus Üzerine Etkileri

Fidan Bener(Darıca Farabi Eğitim ve Araştırma Hastanesi)
Pages
145–149
Publication Date
2018-08-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies are needed to prove what kind of mechanism cause these effects.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introductıon : This study aimed at examining the effects of isotretinoin treatment on menstrual cycle and serum hormones in women with acne vulgaris.
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Key Findings & Data:Results: The mean age of the 21 women included in the study was 22±3.87.
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Conclusion & Impact:Further studies are needed to prove what kind of mechanism cause these effects.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Akne vulgaris · izotretinoin · serum hormonları

Abstract

Introductıon : This study aimed at examining the effects of isotretinoin treatment on menstrual cycle and serum hormones in women with acne vulgaris. Materials and methods: In this retrospective study, the data of female patients who have been treated with isotretinoin for acne vulgaris, had regular menstrual cycles before treatment, had normal laboratory parameters, had no any systemic disease and did not take any medicine have been examined. Results: The mean age of the 21 women included in the study was 22±3.87. The cumulative dose of isotretinoin administered to the patient was 123.90±4.71 mg/kg. During the treatment, in 19.1% of the patients dehydroepiandrosterone sulfate ( DHEAS), in 23.8% of free testosterone (fT) and in 33.3% of total testosterone (tT) were reported to be higher than the reference range of serum levels. There was a statistically insignificant increase in mean DHEAS and fT levels (p>0.05) compared to before treatment. During the treatment, a statistically significant in mean thyroid stimulating hormone (TSH) values (p<0.05) and a insignificant in mean free T3 (fT3) values (p>0.05) was determined progressive decrease between normal limits. There was no significant difference in mean values of 17-hydroxyprogesterone, tT, prolactin, follicle stimulating hormone, luteinizing hormone and free T4 (p>0.05). We found that 23.8% of the patients had menstrual irregularity. In one patient polymenorrhea was observed and hypomenorrhea in another one. Also, oligomenorrhea was observed in three patient, with one of them hemorrhage in the middle of her cycle. It has been determined that there is no change in the hormone levels of patients with menstrual irregularity. Conclusion: In this study show that isotretinoin has an effect on androgen metabolism, on thyroid hormones and on menstrual cycles. For this reason, we recommend follow-up in terms of hyperandrogenism and hypothyroidism in long-term treatment. As a result of the data, it can be said that abnormal uterine bleeding is not hormonal origin. Further studies are needed to prove what kind of mechanism cause these effects.

Özet

Amaç: Akne vulgaris tanısıyla izotretinoin tedavisi kullanan kadın hastaların serum hormon ve menstrüel sikluslarında ortaya çıkan değişikliklerin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Retrospektif olarak yapılan bu çalışmada, akne vulgaris nedeniyle izotretinoin tedavisi başlanmış, tedavi öncesi düzenli menstrüel sikluslara sahip, laboratuvar parametreleri normal sınırlarda olan, herhangi bir sistemik hastalığı bulunmayan ve başka ilaç kullanmayan kadın hastaların verileri incelenmiştir. Bulgular: Çalışmaya dahil edilen 21 hastanın yaş ortalaması 22±3.87 idi. Hastalara uygulanan izotretinoin kümülatif dozu 123.90±4.71 mg/kg idi. Tedavi sırasında hastaların %19.1’inde dehidroepiandrosteron sülfat (DHEAS), %23.8’inde serbest testosteron (sT), %33.3’ünde total testosteron (tT) serum seviyelerinin referans aralığının üzerine çıktığı tespit edildi. Ortalama DHEAS ve sT düzeylerinde tedavi öncesine kıyasla istatistiksel olarak anlamlı olmayan artış saptandı (p>0.05). Tedavi boyunca normal sınırlar arasında ortalama tiroid stimüle edici hormon (TSH) değerlerinde istatistiksel olarak anlamlı (p<0.05) ve ortalama serbest T3 (sT3) düzeylerinde anlamlı olmayan (p>0.05) progresif azalma tespit edildi. Prolaktin, 17-hidroksiprogesteron, tT, folikül stimüle edici hormon, lüteinize edici hormon ve serbest T4 ortalama değerlerinde anlamlı bir fark bulunmadı (p>0.05). Hastaların %23.8'inde menstrüel düzensizlik olduğu saptandı. Bir hastada polimenore, bir hastada hipomenore, üç hastada oligomenore ve oligomenore gelişen hastaların birinde de siklus ortası kanama ortaya çıktığı tespit edildi. Menstrüel düzensizlik gelişen hastaların hormon değerlerinde herhangi bir değişiklik olmadığı belirlendi. Sonuç: Bu çalışma izotretinoinin androjen metaboliması, tiroid hormonları ve menstrüel sikluslar üzerinde etkili olduğunu göstermektedir. Bu nedenle uzun süreli tedavilerde hiperandrojenizm ve hipotiroidi açısından takip önerilmektedir. Anormal uterin kanamaların hormonal kaynaklı olmadığı düşünülmektedir. Bu etkilerin hangi mekanizmalarla ortaya çıktığının kanıtlanabilmesi için ileri seviyede araştırmalara gerek vardır.

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Cite This Article

Bener, F. (2018). The Effects of Isotretinoin on Menstrual Cycle and Hormone Levels. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 51 Sayı: 2, 145–149. https://ajindex.com/articles/1363315

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