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Journals / Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2026 / Cilt: 57 Sayı: 2

Inflammation Biomarkers in Obstructive Sleep Apnea Syndrome and Their Correlation with Disease Severity

Obstruktif Uyku Apne Sendromunda İnflamasyon Biyobelirteçleri ve Hastalık Şiddeti İle İlişkisi

Kübra Mehel Metin(Ankara Eğitim ve Araştırma Hastanesi)0000-0001-6478-5191
Selda Keskin Güler(Ankara Eğitim ve Araştırma Hastanesi)0000-0003-1976-7319
Seçil Özercan(GAZİ ÜNİVERSİTESİ)0000-0002-8439-0004
Tahir Yoldaş(Ankara Eğitim ve Araştırma Hastanesi)0000-0003-4950-9142
Pages
44–48
Publication Date
2024-08-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

KEYWORDS: High density lipoprotein, monocytes, neutrophils, lymphocytes, CRP, obstructive sleep apnea syndrome.

📌 3 Key Takeaways

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Objective & Hypothesis:ÖZET: AMAÇ: Obstrüktif uyku apne sendromu (OUAS) uyku boyunca üst hava yolunun tekrarlayıcı şekilde, tam veya kısmen tıkanmasıyla karakterize bir durumdur.
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Key Findings & Data:GEREÇ VE YÖNTEM: 2016-2019 yılları arasında polisomnografi yapılan 80 hasta çalışmaya dahil edildi.
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Conclusion & Impact:KEYWORDS: High density lipoprotein, monocytes, neutrophils, lymphocytes, CRP, obstructive sleep apnea syndrome.
🔬Design:Araştırma Makalesi
📍Scope:2016-2019 · 80 hasta
⚙️Variables:High density lipoprotein · monosit · nötrofil

Abstract

ÖZET: AMAÇ: Obstrüktif uyku apne sendromu (OUAS) uyku boyunca üst hava yolunun tekrarlayıcı şekilde, tam veya kısmen tıkanmasıyla karakterize bir durumdur. Etiyopatogenezinde inflamasyon rol aldığı gösterilmiştir. Bu çalışmanın amacı inflamasyon belirteçleri olarak önerilen parametrelerin kliniğimizde OUAS tanısı alan hastalarda incelenmesidir. GEREÇ VE YÖNTEM: 2016-2019 yılları arasında polisomnografi yapılan 80 hasta çalışmaya dahil edildi. Apne hipopne indeksi (AHİ) 30’un üstü ağır OUAS (n=20), 15-30 arası orta OUAS (n=20), 5-15 arası olanlar hafif OUAS (n=20), olarak gruplandırıldı. AHI 5’in altında olanlar kontrol grubu olarak çalışmaya alındı (n=20). Kontrol grubu ile OUAS saptanan grup ve OUAS şiddetine göre ayrılmış gruplar arasında monosit/HDL, trombosit/lenfosit, nötrofil/lenfosit oranları, sedimentasyon, CRP, hsCRP, homosistein değerleri karşılaştırıldı. BULGULAR: Kontrol ve OUAS olan gruplar cinsiyet açısından benzerdi. Ağır şiddette OUAS olan grubun yaş ortalaması diğer gruplara göre daha yüksekti. Gruplar arasında trombosit/lenfosit oranları, nötrofil/lenfosit oranları, monosit/HDL oranları, sedimentasyon, homosistein ve hsCRP değerleri açısından istatistiksel anlamlı fark saptanmadı (p>0.05). Kontrol ve OUAS grupları arasında ağır OUAS grubunda CRP düzeyi yüksek olup anlamlı istatistiksel fark saptandı (p 0.05). CRP level was high in the severe OSAS group and a statistically significant difference was found between the control and OSAS groups (p<0.05). There was no significant difference in platelet/lymphocyte ratios, neutro-phil/lymphocyte ratios, monocyte/HDL ratios, sedimentation, homocysteine, hsCRP and CRP ratios between the control and OSAS groups. CRP levels have showed positive with AHI, desaturation index, time elapsed below 90%, body mass index, and age; showed a negative correlation with mi-nimum oxygen saturation and mean oxygen saturation. hsCRP is positive with desaturation index, time elapsed below 90%, body mass index and age; showed a negative correlation with the minimum oxygen saturation and the mean oxygen saturation. DISCUSSION: CRP rates were found to be higher in severe OSAS patients compared to other groups, and it may be a paramater that we can evaluate in terms of inflammation in severe OSAS patients. CONCLUSION: CRP may be a paramater that we can evaluate in terms of inflammation in severe OSAS patients. KEYWORDS: High density lipoprotein, monocytes, neutrophils, lymphocytes, CRP, obstructive sleep apnea syndrome.

Özet

ÖZ: Amaç: Obstrüktif uyku apne sendromu (OUAS) uyku boyunca üst hava yolunun tekrarlayıcı şekil-de, tam veya kısmen tıkanmasıyla karakterize bir durumdur. Etiyopatogenezinde inflamasyon rol aldığı gösterilmiştir. Bu çalışmanın amacı inflamasyon belirteçleri olarak önerilen parametrelerin kliniğimizde OUAS tanısı alan hastalarda incelenmesidir. Gereç ve Yöntem: 2016-2019 yılları arasında polisomnografi yapılan 80 hasta çalışmaya dahil edildi. Apne hipopne indeksi (AHİ) 30’un üstü ağır OUAS (n=20), 15-30 arası orta OUAS (n=20), 5-15 arası olanlar hafif OUAS (n=20), olarak gruplandırıldı. AHI 5’in altında olanlar kontrol grubu olarak çalışmaya alındı (n=20). Kontrol grubu ile OUAS saptanan grup ve OUAS şiddetine göre ayrılmış gruplar arasında monosit/HDL, trombosit/lenfosit, nötrofil/lenfosit oranları, sedimentasyon, CRP, hsCRP, homosistein değerleri karşılaştırıldı. Bulgular: Kontrol ve OUAS olan gruplar cinsiyet açısından benzerdi. Ağır şiddette OUAS olan grubun yaş ortalaması diğer gruplara göre daha yüksekti. Gruplar arasında trombosit/lenfosit oranları, nötrofil/lenfosit oranları, monosit/HDL oranları, sedimentasyon, homosistein ve hsCRP değerleri açısından istatistiksel anlamlı fark saptanmadı (p>0.05). Kontrol ve OUAS grupları arasında ağır OUAS grubunda CRP düzeyi yüksek olup anlamlı istatistiksel fark saptandı (p 0.05). CRP level was high in the severe OSAS group and a statistically significant difference was found between the control and OSAS groups (p<0.05). There was no significant difference in platelet/lymphocyte ratios, neutro-phil/lymphocyte ratios, monocyte/HDL ratios, sedimentation, homocysteine, hsCRP and CRP ratios between the control and OSAS groups. CRP levels have showed positive with AHI, desaturation index, time elapsed below 90%, body mass index, and age; showed a negative correlation with mi-nimum oxygen saturation and mean oxygen saturation. hsCRP is positive with desaturation index, time elapsed below 90%, body mass index and age; showed a negative correlation with the minimum oxygen saturation and the mean oxygen saturation. Discussıon: CRP rates were found to be higher in severe OSAS patients compared to other groups, and it may be a paramater that we can evaluate in terms of inflammation in severe OSAS patients. Conclusıon: CRP may be a paramater that we can evaluate in terms of inflammation in severe OSAS patients. Keywords: High density lipoprotein, monocytes, neutrophils, lymphocytes, CRP, obstructive sleep apnea syndrome.

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Cite This Article

Metin, K. M., Güler, S. K., Özercan, S., Yoldaş, T. (2024). Inflammation Biomarkers in Obstructive Sleep Apnea Syndrome and Their Correlation with Disease Severity. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 57 Sayı: 2, 44–48. https://doi.org/10.20492/aeahtd.1287208

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