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Journals / Abant Tıp Dergisi / 2026 / Cilt: 10 Sayı: 1

The Effect of Neutrophil Lymphocyte Ratio on Prognosis in Patients with Metastatic Renal Cell Carcinoma

Metastatik Renal Hücreli Karsinom Tanılı Hastalarımızda Nötrofil Lenfosit Oranının Prognoz Üzerine Etkisi

Ferhat Ekinci(Manisa Celal Bayar Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji)0000-0002-9317-942X
Atike Pinar Erdoğan(Manisa Celal Bayar Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji)0000-0003-4859-7574
Ahmet Dirican(Manisa Celal Bayar Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji)0000-0001-6992-9289
Gamze Göksel(Manisa Celal Bayar Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji)0000-0002-7991-0036
Pages
134–139
Publication Date
2021-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Overall survival calculated in all patients was 52 months (95% CI: 35-68, std: 6.5).

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The prognostic relationship between malignant tumors and neutrophil lymphocyte ratio (NLR) has been investigated in many cancers, but since there are not enough studies in RCC patients, it was aimed to investigate the prognostic relationship between these patients and NLR in our own hospital data.
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Key Findings & Data:Methods: Records of 38 patients diagnosed with metastatic RCC were analyzed retrospectively.
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Conclusion & Impact:Results: Overall survival calculated in all patients was 52 months (95% CI: 35-68, std: 6.5).
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:renal hücreli karsinom · nötrofil lenfosit oranı · prognoz

Abstract

Purpose: The prognostic relationship between malignant tumors and neutrophil lymphocyte ratio (NLR) has been investigated in many cancers, but since there are not enough studies in RCC patients, it was aimed to investigate the prognostic relationship between these patients and NLR in our own hospital data. Methods: Records of 38 patients diagnosed with metastatic RCC were analyzed retrospectively. ROC analysis was performed to determine the threshold value of NLR in patients and according to the result of the test, the patients were divided into two groups as NLR <2.14 and NLR > 2.14. The two groups were compared in terms of disease-specific survival. Results: Overall survival calculated in all patients was 52 months (95% CI: 35-68, std: 6.5). In 14 (36.8%) patients who were lower than the 2.14 cut off value (<2.14) obtained in the ROC analysis performed to determine the threshold value in the NLR, the mean survival (OS) was 89 months, while the higher (> 2, 14) In 24 (63.2%) patients, OS was detected for 21 months, and this result was reported to be statistically significant (p; 0.03). Conclusion: NLR may be OS related in RCC. However, more studies are needed to determine their routine use.

Özet

Amaç: Maliğn tümörlerle nötrofil lenfosit oranı (NLO) arasındaki prognostik ilişki bir çok kanserde araştırılmış ancak RHK hastalarında yeteri kadar çalışma olmadığı için kendi hastanemiz verilerinde bu hastalar ile NLO arasındaki prognostik ilişkiyi araştırılması amaçlanmıştır. Yöntem: Metastatik RHK tanılı 38 hastanın kayıtları retrospektif olarak incelendi. Hastalarda NLO eşik değerinin belirlenmesi için ROC analizi yapıldı ve testten çıkan sonuca göre hastalar NLO<2,14 ve NLO≥2,14 olmak üzere iki gruba ayrıldı. İki grup, hastalığa özgü sağ kalım açısından karşılaştırıldı. Bulgular: Tüm hastalarda hesaplanan genel sağ kalım 52 ay (% 95 CI:35-68, std:6,5) olarak saptandı. NLO’da eşik değer belirleyebilmek için yapılan ROC analizinde elde edilen 2,14 cut off değerinden düşük olan (< 2,14) 14 (% 36,8) hastada ortalama sağ kalım (OS) 89 ay iken, yüksek olan (>2,14) 24 (% 63,2) hastada ise OS 21 ay saptanmış ve bu sonuç istatistiksel olarak anlamlı (p;0,03) raporlanmıştır. Sonuç: NLO, RHK'de OS ile ilişkili olabilir. Bununla birlikte, rutin kullanımlarını belirlemek için daha fazla çalışmaya ihtiyaç vardır.

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Cite This Article

Ekinci, F., Erdoğan, A. P., Dirican, A., Göksel, G. (2021). The Effect of Neutrophil Lymphocyte Ratio on Prognosis in Patients with Metastatic Renal Cell Carcinoma. Abant Tıp Dergisi, Cilt: 10 Sayı: 1, 134–139. https://doi.org/10.47493/abantmedj.2021.43

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