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Journals / Abant Tıp Dergisi / 2026 / Cilt: 10 Sayı: 2

The Effects of Quercetin and Hyperthermia on OVCAR-3 Cells

Kuersetin ve Hiperterminin OVCAR-3 Hücrelerine Etkileri

Özlem Özgür Gürsoy(Eskisehir Acibadem Hospital)
Canan Vejselova Sezer(FEN FAKÜLTESİ)0000-0002-3792-5993
Ceren Yıldız Eren(Eskişehir Acibadem Hospital)0000-0003-1648-3345
Hulusi Göktuğ Gürer(Eskisehir Acibadem Hospital)0000-0001-8821-9469
Pages
212–218
Publication Date
2021-08-31
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

DISCUSSION and CONCLUSION: Our results demonstrated that quercetin could induce apoptosis in a time and concentration-dependent manner in OVCAR-3 cells.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:INTRODUCTION: This study aims to exhibit the growth inhibitory effect of quercetin on the human ovarian epithelial carcinoma cells (OVCAR-3) and scrutinize the effect of hyperthermia.
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Key Findings & Data:METHODS: OVCAR-3 cells were exposed to different concentrations of quercetin and apoptotic changes were recorded with confocal microscopy and transmission electron microscopy.
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Conclusion & Impact:DISCUSSION and CONCLUSION: Our results demonstrated that quercetin could induce apoptosis in a time and concentration-dependent manner in OVCAR-3 cells.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:kuersetin · OVCAR-3 hücreleri · hipertermi

Abstract

INTRODUCTION: This study aims to exhibit the growth inhibitory effect of quercetin on the human ovarian epithelial carcinoma cells (OVCAR-3) and scrutinize the effect of hyperthermia. METHODS: OVCAR-3 cells were exposed to different concentrations of quercetin and apoptotic changes were recorded with confocal microscopy and transmission electron microscopy. Also Annexin-V and reactive oxygen species (ROS) measurement were analyzed. Cytotoxicity was tested on quercetin exposed OVCAR-3 cells with hyperthermia. RESULTS: Quercetin has good anticancerous activities in vitro by inhibiting the proliferation of OVCAR-3 cells. The recorded IC50 value of quercetin was 122 μM for 48 hours. Hyperthermia didnot influence significantly on the growth inhibition of OVCAR-3 cells applied with quercetin. DISCUSSION and CONCLUSION: Our results demonstrated that quercetin could induce apoptosis in a time and concentration-dependent manner in OVCAR-3 cells.

Özet

Aim: the aim of this study is to exhibit the growth inhibitory effect of quercetin on the human ovarian epithelial carcinoma cells (OVCAR-3) and scrutinize the effect of hyperthermia. Materials and Methods: OVCAR-3 cells were exposed to different concentrations of quercetin and apoptotic changes were recorded with confocal microscopy and transmission electron microscopy. Also Annexin-V analysis and ROS measurement were analyzed. Cytotoxicity was tested on quercetin exposed OVCAR-3 cells with hyperthermia. Results: Quercetin have good anticancerous activities in vitro by inhibiting the proliferation of OVCAR-3 cells. The recorded IC50 value of quercetin was 122 μM for 48 hours. Hyperthermia didnot influence significantly on the growth inhibition of OVCAR-3 cells applied with quercetin. Conclusion: Our results demonstrated that quercetin could induce apoptosis in a time and concentration-dependent manner in OVCAR-3 cells.

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Cite This Article

Gürsoy, Ö. Ö., Sezer, C. V., Eren, C. Y., Gürer, H. G. (2021). The Effects of Quercetin and Hyperthermia on OVCAR-3 Cells. Abant Tıp Dergisi, Cilt: 10 Sayı: 2, 212–218. https://doi.org/10.47493/abantmedj.881050

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