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Journals / Abant Tıp Dergisi / 2023 / Cilt: 12 Sayı: 3

Hormone Levels in Male Cases With Behcet's Disease

Erkek Behçet Hastalarında Hormon Düzeyleri

Tuna Sezer(BOLU ABANT IZZET BAYSAL UNIVERSITY)0000-0002-6861-2869
Hilmi Cevdet Altınyazar(Özel 100. Yıl Hastanesi)0000-0002-7105-2938
Rafet Koca(BÜLENT ECEVİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-1546-5380
Nilgün Solak Tekin(Memorial Ankara Hastanesi)0000-0002-6572-9615
Saniye Çınar(Yeniköy Tıp Merkezi)0000-0003-2041-5097
Pages
200–206
Publication Date
2023-12-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In order to better evaluate the roles of hormones and the hypothalamo-hypophyseal-gonadal axis in relation to the etiopathogenesis of BD, there is a need for larger scale studies, which also take into account disease activity.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Behcet's disease (BD) is a chronic relapsing systemic inflammatory disease with no clear etiopathogenesis.
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Key Findings & Data:Materials and Methods: Our study included 25 male patients with Behcet's disease and 22 healthy males.
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Conclusion & Impact:Conclusion: In order to better evaluate the roles of hormones and the hypothalamo-hypophyseal-gonadal axis in relation to the etiopathogenesis of BD, there is a need for larger scale studies, which also take into account disease activity.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Behçet · Erkek · Hormon

Abstract

Objective: Behcet's disease (BD) is a chronic relapsing systemic inflammatory disease with no clear etiopathogenesis. Because the disease usually starts during the sexually active period and shows a more severe course in males, we aimed to evaluate the hypothalamo-hypophyseal-gonadal axis in male patients. Materials and Methods: Our study included 25 male patients with Behcet's disease and 22 healthy males. In accordance with our purpose, patients and healthy participants were stimulated with gonadotropin releasing hormone (GnRH) followed by examination of the blood for sex hormone binding globulin (SHBG), cortisol, estradiol, free and total testosterone, androstenedione, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), and follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels. The results were compared between the groups. Results: Estradiol levels were significantly higher in the patient group (36.80±14.70 pg/ml) compared to the control group (29.30±9.15 pg/ml) (p=0.045). Conversely, DHEA levels were significantly lower in patient group (13.74±7.96 ng/ml) than in control group (18.36±7.12 ng/ml) (p=0.043). Levels of the other hormones did not show any significant difference between the groups. Conclusion: In order to better evaluate the roles of hormones and the hypothalamo-hypophyseal-gonadal axis in relation to the etiopathogenesis of BD, there is a need for larger scale studies, which also take into account disease activity.

Özet

Amaç: Behçet hastalığı (BH), etiyopatogenezi tam olarak bilinmeyen kronik, relapslarla seyreden sistemik inflamatuvar bir hastalıktır. Hastalığın daha çok cinsel aktif dönemde başlaması ve erkeklerde daha şiddetli klinik seyir göstermesi nedeniyle çalışmamızda erkek hastalarda hipotalamo-hipofizer-gonadal aksı değerlendirmeyi uygun gördük. Gereç ve Yöntemler: Çalışmamıza 25 erkek Behçet hastası ve 22 sağlıklı erkek dahil edildi. Bu amaçla hastalarda ve sağlıklı bireylerde prolaktin, seks hormonu bağlayan globulin (SHBG), kortizol, östradiol, serbest ve total testosteron, androstenedion, dehidroepiandrosteron (DHEA), dehidroepiandrosteron sülfat (DHEAS) ve gonadotropin salgılatıcı hormon (GnRH) testine folikül stimüle eden hormon (FSH) ve luteinize hormon (LH) cevaplarına bakıldı ve sonuçlar karşılaştırıldı. Bulgular: Her iki grup arasında hormon düzeyleri incelendiğinde, hasta grubunda östradiol düzeyleri (36,80±14,70 pg/ml) kontrol grubuna (29,30±9,15 pg/ml) göre anlamlı olarak (p=0,045) daha yüksek bulundu. Hasta grubunda DHEA düzeyleri(13,74±7,96 ng/ml) kontrol grubuna (18,36±7,12 ng/ml) göre anlamlı olarak (p=0,043) daha düşük tespit edilmiştir. Diğer hormonlar açısından gruplar arasında anlamlı fark yoktu. Sonuç: BH’nin etyopatogenezi ile ilişkili olarak hormonların ve hipotalomo-hipofizer-gonadal aksın olası rolünü daha iyi değerlendirmek amacıyla özellikle hastalık aktivitesini de dikkate alan daha geniş serili çalışmalara ihtiyaç vardır.

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Cite This Article

Sezer, T., Altınyazar, H. C., Koca, R., Tekin, N. S., Çınar, S. (2023). Hormone Levels in Male Cases With Behcet's Disease. Abant Tıp Dergisi, Cilt: 12 Sayı: 3, 200–206. https://doi.org/10.47493/abantmedj.1349095

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