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Journals / Acta Medica Alanya / 2026 / Cilt: 5 Sayı: 1

Relationship Between Whole Blood Viscosity and Lower Extremity Peripheral Artery Disease Severity

Tam Kan Akışkanlığı ile Alt Ekstremite Periferik Arter Hastalığı Şiddeti Arasındaki İlişki

Mustafa Yenerçağ(ORDU UNIVERSITY, FACULTY OF MEDICINE)0000-0002-0933-7852
Uğur Arslan(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0001-8572-3571
Metin Çoksevim(ONDOKUZ MAYIS ÜNİVERSİTESİ)0000-0001-6907-6941
Seçkin Dereli(ORDU ÜNİVERSİTESİ)0000-0003-0090-3835
Mustafa Doğduş(UŞAK ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3895-1923
Güney Erdoğan(Sağlık Bilimleri Üniversitesi Samsun Uygulama ve Araştırma Merkezi)0000-0001-5205-1326
Pages
66–74
Publication Date
2021-04-23
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Also WBV values positively correlated with Rutherford symptom severity.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Increased blood viscosity (BV) has good correlaton with lower extremity peripheral artery disease (LEAD).
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Key Findings & Data:Methods: The study included 240 consecutive patients with suspected PAD who had lower extremity peripheral angiography between March 2016 and March 2020.
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Conclusion & Impact:Also WBV values positively correlated with Rutherford symptom severity.
🔬Design:Araştırma Makalesi
📍Scope:2016 Verileri
⚙️Variables:Kan viskozitesi · periferik arter hastalığı · alt ekstremite

Abstract

Aim: Increased blood viscosity (BV) has good correlaton with lower extremity peripheral artery disease (LEAD). However, the relationship between BV and peripheral arterial disease (PAD) severity has not been studied adequately so far. The aim of the present study was to assess the relationship between whole blood viscosity (WBV) and LEAD severity. Methods: The study included 240 consecutive patients with suspected PAD who had lower extremity peripheral angiography between March 2016 and March 2020. A Transatlantic İntersociety Consensus II (TASC II) A-B lesion was defined as simple LEAD, and a TASC II C-D lesion was defined as prevalent and complex LEAD. Symptom severity of all patients were categorized from 0 to 6 according to Rutherford classification. WBV was assessed using a validated calculation formula derived from hematocrit and total plasma protein levels, both at low (LSR) and high (HSR) shear rate. Results: TASC II C-D group presented significantly higher WBV values both at LSR (40.2 ± 9.5 vs. 46.5 ± 13.2; p < 0.001) and HSR (15.9 ± 0.5 vs. 16.5 ± 0,7; p < 0.001). In ROC analysis, a cut-off value of 16.1 WBV at HSR had 73.4% sensitivity and 68.0% specificity for predicting TASC II C-D (AUC: 76.2%, p < 0.001) and a cut-off value of 42.9 WBV at LSR had 73.4% sensitivity and 66.6% specificity for predicting TASC II C-D (AUC: 74.2%, p < 0.001). In multivariate analysis, both high WBV at LSR (OR: 2.121, 95% CI: 1.079 – 3.164, p < 0.001) and high WBV at HSR (OR: 2.737, 95% CI: 1.671 – 4.483, p < 0.001) were independent predictors for TASC II C-D. There was a significant positive correlation between WBV at LSR and Rutherford symptom category (0-6) (r = 0.412, p <0.001) and WBV at HSR and Rutherford symptom category (0-6) (r = 0.402, p <0.001). Conclusion: Our data suggests that; increased WBV values may be associated with TASC II C-D lesions, which indicated more prevalent and complex LEAD. Also WBV values positively correlated with Rutherford symptom severity.

Özet

Amaç: Artmış kan viskozitesinin (BV) alt ekstremite periferik arter hastalığı (LEAD) ile iyi korelasyonu vardır. Ancak, BV ve peripherik arter hastalığı (PAD) şiddeti arasındaki ilişki şu ana kadar yeterince çalışılmamıştır. Bu çalışmanın amacı, tam kan viskozitesi (WBV) ve LEAD şiddeti arasındaki ilişkiyi değerlendirmektir.

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Cite This Article

Yenerçağ, M., Arslan, U., Çoksevim, M., Dereli, S., Doğduş, M., Erdoğan, G. (2021). Relationship Between Whole Blood Viscosity and Lower Extremity Peripheral Artery Disease Severity. Acta Medica Alanya, Cilt: 5 Sayı: 1, 66–74. https://doi.org/10.30565/medalanya.828026

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