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Journals / Acta Medica Alanya / 2025 / Cilt: 9 Sayı: 3

Clinical and Treatment Profile of Late-Onset Bipolar Disorder: A Retrospective Evaluation

Geç Başlangıçlı Bipolar Bozuklukta Klinik ve Tedavi Profili: Retrospektif Bir Değerlendirme

Gökçe Kavak Sinanoğlu(Alanya eğitim ve araştırma hastanesi)0000-0003-4786-2110
Veysel Doğan(ALANYA EDUCATION AND RESEARCH HOSPITAL)0000-0002-8628-2760
Pages
192–198
Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Age at onset is a key determinant for clinical management and treatment planning.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: This study aims to compare the sociodemographic characteristics, clinical course, and treatment approaches of patients diagnosed with early-onset bipolar disorder (EOBD, 0.05), except for employment status (p=0.007).
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Key Findings & Data:The EOBD group had a higher number of manic episodes (p=0.006).
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Conclusion & Impact:Age at onset is a key determinant for clinical management and treatment planning.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Bipolar Bozukluk · Erken Başlangıç · Geç Başlangıç

Abstract

Aim: This study aims to compare the sociodemographic characteristics, clinical course, and treatment approaches of patients diagnosed with early-onset bipolar disorder (EOBD, 0.05), except for employment status (p=0.007). The EOBD group had a higher number of manic episodes (p=0.006). Lithium use was more frequent in LOBD patients, although not statistically significant (p=0.295), while olanzapine use was statistically significant (p=0.010). Antidepressant use was low in both groups (p=0.156). Conclusion: Late-onset bipolar disorder may present with distinct clinical features and treatment preferences compared to early-onset cases. Age at onset is a key determinant for clinical management and treatment planning.

Özet

Amaç: Bu çalışma, hastalık başlangıç yaşına göre; erken başlangıçlı bipolar bozukluk (EBBB 0.05), ancak istihdam durumu açısından fark gözlendi (p=0.007). EBBB grubunda manik atak sayısı daha yüksek bulundu (p=0.006), GBBB grubunda lityum kullanımı daha sık tercih edildi (p=0.295, anlamlı değil), olanzapin kullanımı istatistiksel olarak anlamlıydı (p=0.010). Her iki grupta antidepresan kullanımı düşüktü (p=0.156). Sonuç: Geç başlangıçlı bipolar bozukluk, erken başlangıçlı hastalardan farklı klinik özellikler ve tedavi tercihleri sergileyebilir. Hastalık başlangıç yaşı, tedavi stratejileri ve klinik değerlendirmelerde önemli bir belirleyicidir.

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Cite This Article

Sinanoğlu, G. K., Doğan, V. (2025). Clinical and Treatment Profile of Late-Onset Bipolar Disorder: A Retrospective Evaluation. Acta Medica Alanya, Cilt: 9 Sayı: 3, 192–198. https://doi.org/10.30565/medalanya.1756300

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References (21)

  1. Oliva V, Fico G, De Prisco M, Gonda X, Rosa AR, Vieta E. Bipolar disorders: an update on critical aspects. Lancet Reg Health Eur. 2025;48:101135. doi: 10.1016/j.lanepe.2024.101135.
  2. Frisardi V, Pollorsi C, Sambati L, Macchiarulo M, Fabbo A, Neviani F, et al. The Italian Framework of Bipolar Disorders in the Elderly: Old and Current Issues and New Suggestions for the Geriatric Psycho-Oncology Research. Biomedicines. 2023;11(5):1418. doi: 10.3390/biomedicines11051418.
  3. Ljubic N, Ueberberg B, Grunze H, Assion HJ. Treatment of bipolar disorders in older adults: a review. Ann Gen Psychiatry. 2021;20(1):45. doi: 10.1186/s12991-021-00367-x.
  4. Prabhakar D, Balon R. Late-onset bipolar disorder: a case for careful appraisal. Psychiatry (Edgmont). 2010;7(1):34-7. PMID: 20386635
  5. Sajatovic M, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, et al. Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project. Bipolar Disord. 2022;24(2):195-206. doi: 10.1111/bdi.13119.
  6. Coryell W, Fiedorowicz J, Solomon D, Endicott J. Age transitions in the course of bipolar I disorder. Psychol Med. 2009;39(8):1247-52. doi: 10.1017/S0033291709005534.
  7. Subramaniam H, Dennis MS, Byrne EJ. The role of vascular risk factors in late onset bipolar disorder. Int J Geriatr Psychiatry. 2007;22(8):733-7. doi: 10.1002/gps.1730.
  8. Hahn C, Lim HK, Lee CU. Neuroimaging Findings in Late-Onset Schizophrenia and Bipolar Disorder. J Geriatr Psychiatry Neurol. 2014;27(1):56-62. doi: 10.1177/0891988713516544.
  9. Tohen M, Shulman KI, Satlin A. First-episode mania in late life. Am J Psychiatry. 1994;151(1):130-2. doi: 10.1176/ajp.151.1.130.
  10. Rej S, Herrmann N, Shulman K, Fischer HD, Fung K, Gruneir A. Current psychotropic medication prescribing patterns in late-life bipolar disorder. Int J Geriatr Psychiatry. 2017;32(12):1459-65. doi: 10.1002/gps.4635.
  11. Beunders AJM, Orhan M, Dols A. Older age bipolar disorder. Curr Opin Psychiatry. 2023;36(5):397-404. doi: 10.1097/YCO.0000000000000883.
  12. Arnold I, Dehning J, Grunze A, Hausmann A. Old Age Bipolar Disorder—Epidemiology, Aetiology and Treatment. Medicina (Kaunas). 2021;57(6):587. doi: 10.3390/medicina57060587.
  13. Suominen K, Mantere O, Valtonen H, Arvilommi P, Leppämäki S, Paunio T, et al. Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking. Bipolar Disord. 2007;9(7):698-705. doi: 10.1111/j.1399-5618.2007.00388.x
  14. Schürhoff F, Bellivier F, Jouvent R, Mouren-Siméoni MC, Bouvard M, Allilaire JF, et al. Early and late onset bipolar disorders: two different forms of manic-depressive illness? J Affect Disord. 2000;58(3):215-21. doi: 10.1016/S0165-0327(99)00111-1.
  15. Lavin P, Buck G, Almeida OP, Su C-L, Eyler LT, Dols A, et al. Clinical correlates of late-onset versus early-onset bipolar disorder in a global sample of older adults. Int J Geriatr Psychiatry. 2022;37(12). doi: 10.1002/gps.5833.
  16. Depp CA, Jeste DV. Bipolar disorder in older adults: a critical review. Bipolar Disord. 2004;6(5):343-67. doi: 10.1111/j.1399-5618.2004.00139.x.
  17. Aziz R, Lorberg B, Tampi RR. Treatments for late-life bipolar disorder. Am J Geriatr Pharmacother. 2006;4(4):347-64. doi: 10.1016/j.amjopharm.2006.12.007.
  18. O'Brien P, Oyebode F. Psychotropic medication and the heart. Adv Psychiatr Treat. 2003;9(6):414-23. doi: 10.1192/apt.9.6.414.
  19. Mukhopadhyay S, Dutta P, Banerjee S, Bhattacharya B, Biswas S, Navari RM. Low-dose olanzapine, sedation and chemotherapy-induced nausea and vomiting: a prospective randomized controlled study. Future Oncol. 2021;17(16):2041-56. doi: 10.2217/fon-2020-0834.
  20. Gitlin MJ. Antidepressants in bipolar depression: an enduring controversy. Int J Bipolar Disord. 2018;6(1):25. doi: 10.1186/s40345-018-0133-9.
  21. Rej S, Herrmann N, Shulman K, Fischer HD, Fung K, Gruneir A. Current psychotropic medication prescribing patterns in late-life bipolar disorder. Int J Geriatr Psychiatry. 2017;32(12):1459-65. doi: 10.1002/gps.4635.