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Journals / Acta Medica Alanya / 2025 / Cilt: 9 Sayı: 3

Serum Lipid Levels in Patients with Diabetic Retinopathy

Diyabetik Retinopatili Hastalarda Serum Lipid Seviyeleri

Bilge Başdoğan(UNIVERSITY OF HEALTH SCIENCES, ADANA NUMUNE HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE)0000-0002-2617-7790
Nedime Sahinoglu Keskek(ALANYA ALAADDIN KEYKUBAT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICINE)0000-0001-8544-103X
Utku Özilice(ALANYA ALAADDIN KEYKUBAT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE)0009-0009-9381-3409
Cihad Raufoğlu(ALANYA ALAADDIN KEYKUBAT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE)0009-0000-0153-7887
Özden Özilice(Antalya Alanya İlçe Sağlık Müdürlüğü)0000-0003-3568-728X
Şakir Özgür Keşkek(UNIVERSITY OF HEALTH SCIENCES, ADANA NUMUNE HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE)0000-0001-5888-3123
Pages
185–191
Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients with diabetes should be examined for dyslipidemia to delay the development of vascular complications.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Diabetic retinopathy is one of the most common microvascular complications of diabetes mellitus.
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Key Findings & Data:Methods: This retrospectively designed study included 1363 individuals: 352 patients with type 2 diabetes and retinopathy, 553 patients with type 2 diabetes without retinopathy, and 457 healthy individuals.
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Conclusion & Impact:Patients with diabetes should be examined for dyslipidemia to delay the development of vascular complications.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Diyabetik Retinopati · Dislipidemi · Yüksek Yoğunluklu Lipoprotein

Abstract

Aim: Diabetic retinopathy is one of the most common microvascular complications of diabetes mellitus. This study aimed to investigate the association between DR and dyslipidemia. Methods: This retrospectively designed study included 1363 individuals: 352 patients with type 2 diabetes and retinopathy, 553 patients with type 2 diabetes without retinopathy, and 457 healthy individuals. There were 202 and 150 patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), respectively. The groups were compared according to their demographic properties, high-density lipoprotein (HDL), triglyceride (TG), low-density lipoprotein (LDL), glycosylated hemoglobin (HbA1c) and serum fasting glucose levels. MedCalc 15.8 (MedCalc Belgium) was used for the statistical analysis. Results: The groups were similar in terms of age and sex (p>0.05). Serum HDL levels were lower in patients with DR than in those without retinopathy (p<0.001). Patients with PDR had lower HDL levels than those with NPDR (p=0.011). There was an association between low HDL level and PDR (Odds Ratio: 2.1, %95 Cl: 1.4 3.1, p=0.003). Conclusion: In this study, we observed low serum HDL levels in patients with PDR. Low serum HDL levels are associated with atherosclerosis and other vascular disorders. Patients with diabetes with low serum HDL levels may be more predisposed to retinopathy. Patients with diabetes should be examined for dyslipidemia to delay the development of vascular complications.

Özet

Amaç: Diyabetik retinopati, diyabetes mellitusun en sık görülen komplikasyonlarından biridir. Bu çalışmanın amacı, diyabetik retinopati ve dislipidemi arasındaki ilişkiyi incelemektir. Yöntem: Retrospektif olarak planlanan çalışmaya toplam 1363 birey dahil edildi: Tip 2 diyabet ve retinopatisi olan 352 hasta, retinopatisi olmayan 553 tip 2 diyabetli hasta ve 457 sağlıklı birey. Non proliferatif diyabetik retinopati (NPDR) ve proliferatif diyabetik retinopati (PDR) gruplarında sırayla 202 ve 150 hasta vardı. Gruplar, demografik veriler, yüksek yoğunluklu lipoprotein (HDL), trigliserid (TG), düşük yoğunluklu lipoprotein (LDL), glikolize hemoglobin (HbA1c) ve açlık kan şekeri düzeyleri açısından karşılaştırıldı. İstatiksel olarak verilerin değerlendirilmesinde MedCalc 15.2.2 (MedCalc Belgium) istatistik paket programı kullanıldı. Bulgular: Gruplar yaş ve cinsiyet açısından benzer bulundu (her biri için p>0.05). Serum HDL düzeyleri diyabetik retinopatisi olan hastalarda retinopatisi olmayanlara göre daha düşüktü (p<0.001). PDR olan hastalarda Serum HDL düzeyi NPDR olan hastalara göre daha düşüktü (p=0.011). Retinopatisi olan hastalarda düşük HDL düzeyi PDR ile ilişkili bulundu (OR:2.1, %95 Cl: 1.4-3.1, p=0.003). Sonuç: Bu çalışmada, PDR’si olan hastalarda HDL düzeylerini düşük bulduk. Düşük HDL ateroskleroz ve diğer vasküler problemlerle ilişkilidir. Düşük HDL düzeyi diyabetik hastalarda retinopatiye yatkınlık oluşturabilir. Vasküler komplikasyonların gelişimini geciktirmek için diyabetik hastalar dislipidemi açısından incelenmelidir.

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Cite This Article

Başdoğan, B., Keskek, N. S., Özilice, U., Raufoğlu, C., Özilice, Ö., Keşkek, Ş. Ö. (2025). Serum Lipid Levels in Patients with Diabetic Retinopathy. Acta Medica Alanya, Cilt: 9 Sayı: 3, 185–191. https://doi.org/10.30565/medalanya.1732116

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