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Journals / Acta Medica Alanya / 2025 / Cilt: 9 Sayı: 3

Could Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) score predict poor prognosis in patients with acute ischemic stroke?

Hemoglobin, Albümin, Lenfosit ve Trombosit (HALP) skoru akut iskemik inmeli hastalarda kötü prognozu öngörebilir mi?

İlkin İyigündoğdu(BAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0001-7860-040X
Güven Girgin(BAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0002-6077-9824
Zeynep Kaya(BAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0003-4764-8624
Eda Derle(BAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0003-2122-1016
Ülkü Sibel Benli(BAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0002-9975-3170
Pages
165–171
Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, it should be kept in mind that markers such as the HALP score should be evaluated together with other clinical parameters and the general condition of the patient.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: HALP (Hemoglobin, Albumin, Lymphocyte and Platelet) score was shown to have an association with prognosis in malignancies.
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Key Findings & Data:The functional status of the patients at discharge were assessed by the Modified Rankin Scale, and patients with mRS≥3 were considered to have a poor prognosis.
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Conclusion & Impact:Therefore, it should be kept in mind that markers such as the HALP score should be evaluated together with other clinical parameters and the general condition of the patient.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:HALP skoru · prognoz · iskemik inme

Abstract

Aim: HALP (Hemoglobin, Albumin, Lymphocyte and Platelet) score was shown to have an association with prognosis in malignancies. However, the relationship between HALP score and prognosis in ischemic stroke is not clear. This study aimed to evaluate the relationship between HALP score and functional outcomes at discharge in patients with acute ischemic stroke. Methods: A retrospective analysis was conducted on patients hospitalized with acute ischemic stroke. The HALP score was calculated. The functional status of the patients at discharge were assessed by the Modified Rankin Scale, and patients with mRS≥3 were considered to have a poor prognosis. The relationship between the HALP score, early functional results, and mortality rates of the patients was statistically evaluated. p< 0.05 was considered as significant. Results: After exclusion criteria, data of 159 patients were analyzed. The median HALP score was 41.68. At discharge, 57 patients (35.8%) had poor prognosis. The median HALP score was significantly lower in patients with poor prognosis compared to those with good prognosis (p<0.001). The HALP score was lower in patients with mortality than patients that survive (p<0.001). The optimal cut-off value for the HALP score to predict prognosis at discharge was 37.945. Conclusion: The HALP score may be valuable for predicting prognosis in patients with ischemic stroke. However, many variables of patients can affect prognosis. Therefore, it should be kept in mind that markers such as the HALP score should be evaluated together with other clinical parameters and the general condition of the patient.

Özet

Amaç: Daha önce, HALP (Hemoglobin, Albümin, Lenfosit ve Trombosit) skorunun malignitelerde prognozla ilişkili olduğu gösterilmiştir. Ancak, iskemik inme hastalarında HALP skoru ile prognoz arasındaki ilişki net değildir. Bu çalışmada, akut iskemik inme hastalarında HALP skoru ile taburculuk fonksiyonel sonuçları arasındaki ilişkiyi değerlendirmeyi amaçladık. Yöntemler: Akut iskemik inme tanısıyla hastaneye yatırılan hastalar retrospektif olarak incelendi. Hastalarda HALP skoru hesaplandı. Hastaların taburculuktaki fonksiyonel durumları Modifiye Rankin Ölçeği (mRS) ile değerlendirildi ve mRS≥3 olan hastalar kötü prognoza sahip olarak kabul edildi. HALP skoru ile erken fonksiyonel sonuçlar ve hastaların mortalite oranları arasındaki ilişki istatistiksel olarak değerlendirildi. İstatistiksel anlamlılık düzeyi olarak p< 0,05 kabul edildi. Bulgular: Dışlama kriterlerinden sonra, çalışmada 159 hastanın verisi analiz edildi. Hastalarda medyan HALP skoru 41.68 saptandı. Taburculukta 57 hasta (%35.8) kötü prognoza sahipti. İyi prognoza sahip hastalara kıyasla kötü prognoza sahip hastalarda medyan HALP skoru anlamlı olarak daha düşük bulundu (p<0.001). Ayrıca mortalite olan hastalarda hayatta kalan hastalara göre medyan HALP skoru daha düşük gözlendi (p<0.001). HALP skorunun gücü, taburculuktaki hastaların prognozu için değerlendirildi ve HALP skoru için optimum kesme değeri 37.945 olarak bulundu. Sonuç: HALP skoru iskemik inmeli hastalarda prognozu tahmin etmede değerli olabilir. Ancak, hastaların birçok değişkeni prognozu etkileyebilir. Bu nedenle, HALP skoru gibi belirteçlerin, diğer klinik parametreler ve hastanın genel durumu ile birlikte değerlendirilmesi gerektiği akılda tutulmalıdır.

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Cite This Article

İyigündoğdu, İ., Girgin, G., Kaya, Z., Derle, E., Benli, Ü. S. (2025). Could Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) score predict poor prognosis in patients with acute ischemic stroke?. Acta Medica Alanya, Cilt: 9 Sayı: 3, 165–171. https://doi.org/10.30565/medalanya.1692942

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