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Journals / Düzce Tıp Fakültesi Dergisi / 2026 / Volume: 22 Issue: 2

Healing Effects of Single-Dose Triptolide in Rats with Severe Acute Pancreatitis

Şiddetli Akut Pantreatitli Ratlarda Tek-Doz Triptolitin İyileşmeye Etkisi

Hüseyin Özden(Ahi Evran University Faculty of Medicine Department of General Surgery)0000-0002-2786-3805
Asuman Kilitci(Ahi Evran University Faculty of Medicine Department of Pathology)0000-0002-5489-2222
Yaşar Şahin(Kırıkkale University Faculty of Veterinary Medicine Department of Pharmacology And Toxicology)0000-0001-5936-4210
Gökhan Karaca(Kırıkkale University Faculty of Medicine Department of General Surgery)0000-0002-5107-5999
Haldun Umudum(Ufuk University Faculty of Medicine Department of Pathology)0000-0002-4550-1971
Ahmet Yıldız(Kırıkkale University Faculty of Medicine Department of General Surgery)0000-0002-6889-4528
Erkan Dulkadiroğlu(Kirsehir Training and Research Hospital Department of İnternal Medicine)0000-0001-7665-7453
Pages
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Publication Date
2020-08-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, it was aimed to investigate the healing effects of triptolide, an anti-inflammatory and immunosuppressive agent in rats with SAP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Severe acute pancreatitis (SAP) carries high morbidity and mortality risk.
📊
Key Findings & Data:If the proinflammatory response phase of SAP cannot be controlled, it may result in multiorgan failure (MOF).
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Conclusion & Impact:In this study, it was aimed to investigate the healing effects of triptolide, an anti-inflammatory and immunosuppressive agent in rats with SAP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Severe acute pancreatitis · cerulean · triptolide

Abstract

Aim: Severe acute pancreatitis (SAP) carries high morbidity and mortality risk. If the proinflammatory response phase of SAP cannot be controlled, it may result in multiorgan failure (MOF). Nuclear factor-kappa B (NF-κB) activation plays an important role in the development of MOF. In this study, it was aimed to investigate the healing effects of triptolide, an anti-inflammatory and immunosuppressive agent in rats with SAP.

Özet

Amaç: Şiddetli akut pankreatit (SAP) yüksek morbidite ve mortalite riski taşır. SAP'nin proenflamatuar yanıt fazı kontrol edilemezse, çoklu organ yetmezliği (ÇOY) ile sonuçlanabilir. Nükleer faktör-kappa B (NF-κB) aktivasyonu ÇOY'un gelişiminde önemli bir rol oynar. Bu çalışmada, bir anti-enflamatuar ve immünsüpresif ajan olan triptolidin SAP'lı sıçanlarda iyileştirici etkilerinin araştırılması amaçlanmıştır.

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Cite This Article

Özden, H., Kilitci, A., Şahin, Y., Karaca, G., Umudum, H., Yıldız, A., Dulkadiroğlu, E. (2020). Healing Effects of Single-Dose Triptolide in Rats with Severe Acute Pancreatitis. Düzce Tıp Fakültesi Dergisi, Volume: 22 Issue: 2. https://doi.org/10.18678/dtfd.728067

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