Journals / Düzce Tıp Fakültesi Dergisi / 2026 / Volume: 27 Issue: 1

Evaluation of Osteoarticular Involvement Associated with Brucellosis in Children

Çocukluk Çağı Brusellozuna İlişkin Osteoartiküler Tutulumun Değerlendirilmesi

Tuğba Nur Kutlu Beşeren(KAFKAS ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-4583-0860
Hayrunnisa Bekis Bozkurt(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL ÜMRANİYE SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-8642-4872
Müferet Ergüven(DÜZCE ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3255-1208
Zafer Bıçakçı(KAFKAS ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1321-4708
Pages
—
Publication Date
2025-04-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients should be closely followed up in terms of brucellosis complications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Brucellosis is a significant public health problem with high morbidity.
📊
Key Findings & Data:Material and Methods: This retrospective study included pediatric patients between the ages of 1 and 18 years who were hospitalized and diagnosed with brucellosis between 2015 and 2020, and were regularly followed up. and all their findings and osteoarticular involvement data within the last two years were recorded.
💡
Conclusion & Impact:Patients should be closely followed up in terms of brucellosis complications.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:brucellosis · osteoarthritis · sacroiliac joint

Abstract

Aim: Brucellosis is a significant public health problem with high morbidity. Its most frequent complication is osteoarticular involvement. The study aimed to evaluate the relationship of osteoarticular involvement with clinical features and prognosis in children with brucellosis. Material and Methods: This retrospective study included pediatric patients between the ages of 1 and 18 years who were hospitalized and diagnosed with brucellosis between 2015 and 2020, and were regularly followed up. and all their findings and osteoarticular involvement data within the last two years were recorded. Clinical features, laboratory findings, osteoarticular involvement, and relapse rates of the patients were evaluated. Results: A total of 80 patients were included study. During the follow-up period, relapse developed in 14 (17.5%) patients. The most commonly affected joints were right (40%, n=32) and left (26.3%, n=21) hips, then right (27.5%, n=22) and left (23.8%, n=19) knees. Shoulder joint involvement rates and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), alanine transaminase (ALT), and aspartate aminotransferase (AST) levels were statistically significantly higher in the relapse group (p=0.016, p=0.003, p=0.001, p<0.001, p<0.001, respectively). There was no significant difference in demographic characteristics, clinical features, and treatment responses of the patients between age groups, except weakness and sweating complaints that were high among older children (p=0.036). Conclusion: High admission ALT, AST, CRP, and ESR levels in brucellosis cases with osteoarticular involvement and the presence of shoulder joint involvement, albeit rarely, can be a warning sign in terms of relapse. Patients should be closely followed up in terms of brucellosis complications.

Özet

Amaç: Bruselloz, yüksek morbiditeye sahip önemli bir halk sağlığı sorunudur. En sık görülen komplikasyonu osteoartiküler tutulumdur. Bu çalışmanın amacı, bruselloz tanılı çocuklarda osteoartiküler tutulumun klinik özellikler ve prognoz ile ilişkisini değerlendirmektir. Gereç ve Yöntemler: Geriye dönük bu çalışmaya, 2015 ve 2020 yılları arasında bruselloz tanısıyla hastaneye yatırılan ve düzenli takipleri yapılan 1 ile 18 yaş aralığındaki pediatrik hastalar dahil edildi. Son iki yıldaki tüm bulguları ve osteoartiküler tutulum verileri kaydedildi. Hastaların klinik özellikleri, laboratuvar bulguları, osteoartiküler tutulum ve nüks oranları değerlendirildi. Bulgular: Çalışmaya toplam 80 hasta dahil edildi. Takip süresinde hastaların 14 (%17,5) hastada relaps gelişti. En sık etkilenen eklemler sağ (%40, n=32) ve sol (%26,3, n=21) kalçalar, ardından sağ (%27,5, n=22) ve sol (%23,8, n=19) dizlerdi. Omuz eklem tutulum oranları ile C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESH), alanin transaminaz (ALT) ve aspartat aminotransferaz (AST) düzeyleri relaps grubunda istatistiksel olarak anlamlı şekilde daha yüksekti (sırasıyla p=0,016, p=0,003, p=0,001, p<0,001, p<0,001). Sadece yaşı büyük çocuklarda daha yüksek olan güçsüzlük ve terleme şikayetleri dışında (p=0,036), hastaların demografik özellikleri, klinik özellikleri ve tedavi yanıtları bakımından yaş grupları arasında anlamlı bir farklılık yoktu. Sonuç: Osteoartiküler tutulumu olan bruselloz olgularında yüksek başvuru ALT, AST, CRP ve ESR düzeyleri ve nadir de olsa omuz eklem tutulumunun varlığı relaps açısından uyarıcı olabilir. Hastalar bruselloz komplikasyonları açısından yakından takip edilmelidir.

🔖

Cite This Article

Beşeren, T. N. K., Bozkurt, H. B., Ergüven, M., Bıçakçı, Z. (2025). Evaluation of Osteoarticular Involvement Associated with Brucellosis in Children. Düzce Tıp Fakültesi Dergisi, Volume: 27 Issue: 1. https://doi.org/10.18678/dtfd.1579167

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (27)

  1. Kaman A, Öz FN, Fettah A, Durmuş SY, Teke TA, Tanır G. Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings. Turk J Pediatr. 2022;64(1):10-8.
  2. Savion N, Guzner N, Hashavya S, Reif S, Ohana Sarna Cahan L. Brucellosis in pediatric populations: An 11-year cohort study. Isr Med Assoc J. 2023;25(8):542-6.
  3. Tanir G, Tufekci SB, Tuygun N. Presentation, complications, and treatment outcome of brucellosis in Turkish children. Pediatr Int. 2009;51(1):114-9.
  4. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14(6):e469-78.
  5. Bukhari EE. Pediatric brucellosis. An update review for the new millennium. Saudi Med J. 2018;39(4):336-41.
  6. Bosilkovski M, Zezoski M, Siskova D, Miskova S, Kotevska V, Labacevski N. Clinical characteristics of human brucellosis in patients with various monoarticular involvements. Clin Rheumatol. 2016;35(10):2579-84.
  7. Khateeb MI, Araj GF, Majeed SA, Lulu AR. Brucella arthritis: A study of 96 cases in Kuwait. Ann Rheum Dis. 1990;49(12):994-8.
  8. Geyik MF, Gür A, Nas K, Çevik R, Saraç J, Dikici B, et al. Musculoskeletal involvement in brucellosis in different age groups: A study of 195 cases. Swiss Med Wkly. 2002;132(7-8):98-104.
  9. Dutta D, Sen A, Gupta D, Kuila P, Chatterjee D, Sanyal S, et al. Childhood brucellosis in Eastern India. Indian J Pediatr. 2018;85(4):266-71.
  10. Wang W, Wang Z, Jia K, Tang J, Wang L. Clinical and laboratory characteristics of childhood brucellosis in high-risk area of Western China. Jpn J Infect Dis. 2022;75(2):127-32.
  11. Criado MD, MacHain UB, Rey LV, Antón MP, Loza SM, Alcobendas Rueda RM, et al. Evaluation of diagnostic tests in pediatric brucellosis. Eur J Pediatr. 2019;178(11):1707-8.
  12. Kara SS, Cayir Y. Predictors of blood culture positivity in pediatric brucellosis. J Coll Physicians Surg Pak. 2019;29(7):665-70.
  13. Pourakbari B, Abdolsalehi M, Mahmoudi S, Banar M, Masoumpour F, Mamishi S. Epidemiologic, clinical, and laboratory characteristics of childhood brucellosis: A study in an Iranian childrenʼs referral hospital. Wien Med Wochenschr. 2019;169(9-10):232-9.
  14. Parlak M, Akbayram S, Doğan M, Tuncer O, Bayram Y, Ceylan N, et al. Clinical manifestations and laboratory findings of 496 children with brucellosis in Van, Turkey. Pediatr Int. 2015;57(4):586-9.
  15. Bozukluhan K, Merhan O, Celebi O, Buyuk F, Ogun M, Gokce G. Levels of certain biochemical and oxidative stress parameters in cattle with Brucellosis. J Hellenic Vet Med Soc. 2017;68(3):285-90.
  16. Albayrak A, Albayrak F. Hepatic granulomas associated with brucellosis: Hepatic granulomas and brucellosis. Hepat Mon. 2011;11(1):1-2.
  17. Çiftdoğan DY, Aslan S. Osteoarticular involvement of brucellosis in pediatric patients: Clinical and laboratory characteristics. Turk J Pediatr. 2020;62(2):199-207.
  18. Turan H, Serefhanoglu K, Karadeli E, Togan T, Arslan H. Osteoarticular involvement among 202 brucellosis cases identified in Central Anatolia region of Turkey. Intern Med. 2011;50(5):421-8.
  19. Zamani A, Kooraki S, Mohazab RA, Zamani N, Matloob R, Hayatbakhsh MR, et al. Epidemiological and clinical features of Brucella arthritis in 24 children. Ann Saudi Med. 2011;31(3):270-3.
  20. Bosilkovski M, Kirova-Urosevic V, Cekovska Z, Labacevski N, Cvetanovska M, Rangelov G, et al. Osteoarticular involvement in childhood brucellosis: Experience with 133 cases in an endemic region. Pediatr Infect Dis J. 2013;32(8):815-9.
  21. Hashemi SH, Keramat F, Ranjbar M, Mamani M, Farzam A, Jamal-Omidi S. Osteoarticular complications of brucellosis in Hamedan, an endemic area in the west of Iran. Int J Infect Dis. 2007;11(6):496-500.
  22. Turan Ozden H, Togan T. Osteoarticular involvement among brucellosis cases in Konya city. Cukurova Med J. 2015;40(3):483-94. Turkish.
  23. Ebrahimpour S, Bayani M, Moulana Z, Hasanjani Roushan MR. Skeletal complications of brucellosis: A study of 464 cases in Babol, Iran. Caspian J Intern Med. 2017;8(1):44-8.
  24. Özger HS, Karaşahin Ö, Yildiz Y, Dizbay M. Osteoarticular involvement and inadequate treatment of brucellosis are related to relapse. Mediterr J Infect Microb Antimicrob. 2020;9(1):1.
  25. Hendaus MA, Qaqish RM, Alhammadi AH. Neurobrucellosis in children. Asian Pac J Trop Biomed. 2015;5(2):158-61.
  26. Akbayram S, Dogan M, Peker E, Bektas MS, Caksen H, Karahocagil M. Evaluation of children with neurobrucellosis. Bratisl Lek Listy. 2012;113(7):424-30.
  27. Su XW, Feng WY, Li JL, Song RX, Wu RH, Zhu H. Brucella meningoencephalitis in children with status epilepticus: A case report and literature review. China Trop Med. 2023;23(3):319-22.