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Journals / Düzce Tıp Fakültesi Dergisi / 2026 / Volume: 27 Issue: 1

Evaluation of Vitamin D and Hematological Parameters in Pediatric Non-Scarring Alopecias

Pediatrik Non-Skatrisyel Alopesilerde Vitamin D ve Hematolojik Parametrelerin Değerlendirilmesi

Betül Şereflican(BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ)0000-0001-9947-7690
Merve Dilcan(BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ)0000-0001-9870-4767
Mualla Polat(BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ)0000-0001-9226-5134
Pages
—
Publication Date
2025-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Neu/lym ratio may be a more appropriate inflammatory marker for patients with TE than the other nonscarring alopecia.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Vitamin D is an important factor for the hair follicle cycle.
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Key Findings & Data:Material and Methods: A total of 157 patients under the age of 18 and diagnosed with AA, AGA, and TE were included in this retrospective study.
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Conclusion & Impact:Neu/lym ratio may be a more appropriate inflammatory marker for patients with TE than the other nonscarring alopecia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Alopecia · alopecia areata · androgenetic alopecia

Abstract

Aim: Vitamin D is an important factor for the hair follicle cycle. Alopecia areata (AA), androgenetic alopecia (AGA), and telogen effluvium (TE) are the most common forms of non-scarring alopecia. This study aimed to define vitamin D levels and hemogram parameters in children and adolescents with non-cicatricial alopecia. Material and Methods: A total of 157 patients under the age of 18 and diagnosed with AA, AGA, and TE were included in this retrospective study. Vitamin D levels, and neutrophil/lymphocyte (neu/lym) and platelet/lymphocyte (plt/lym) ratios were evaluated. Vitamin D levels were examined in four different groups according to the admission period as autumn, winter, spring, and summer. Results: Of the patients, 30 were diagnosed with AA, 11 with AGA, and 116 with TE. Vitamin D deficiency was detected in 128 of 153 patients, of whom vitamin D levels were examined, insufficiency in 20, and sufficiency in 5. There was no statistically significant difference in vitamin D levels between groups (p=0.114). Also, no statistically significant difference was found between the groups in terms of vitamin D deficiency and insufficiency (p=0.403). Vitamin D levels were significantly higher in males than in females (p<0.001), and in autumn than in winter (p=0.043). The ratio of neu/lym in patients with TE was significantly higher than the patients in the AA group (p=0.005). Conclusion: Vitamin D deficiency was seen in a very high percentage of all non-cicatricial alopecia. Neu/lym ratio may be a more appropriate inflammatory marker for patients with TE than the other nonscarring alopecia.

Özet

Amaç: D vitamini saç folikülü döngüsü için önemli bir faktördür. Alopesi areata (AA), androgenetik alopesi (AGA) ve telogen effluvium (TE) skarsız alopesilerin en sık görülen formlarıdır. Bu çalışmada non-skatrisyel alopesisi olan çocuk ve adölesanlarda D vitamini düzeylerinin ve hemogram parametrelerininin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Bu geriye dönük çalışmaya AA, AGA ve TE tanısı almış ve 18 yaş altı olan toplam 157 hasta dahil edildi. D vitamini düzeyleri ile nötrofil/lenfosit (neu/lym) ve platelet/lenfosit (plt/lym) oranları değerlendirildi. D vitamini düzeyleri başvuru dönemine göre sonbahar, kış, ilkbahar ve yaz olmak üzere dört farklı grupta incelendi. Bulgular: Tüm hastaların 30'u AA, 11'i AGA ve 116'sı TE tanısı aldı. D vitamini düzeylerine bakılmış olan 153 hastanın 128'inde D vitamini eksikliği, 20'sinde yetersizlik, 5'inde ise yeterlilik saptandı. Gruplar arasında D vitamini düzeyleri açısından istatistiksel olarak anlamlı bir farklılık yoktu (p=0,114). Ayrıca, gruplar arasında D vitamini eksikliği ve yetersizliği açısından da istatistiksel olarak anlamlı bir fark bulunmadı (p=0,403). D vitamini düzeyleri erkeklerde kadınlara göre (p<0,001) ve sonbaharda kışa göre (p=0,043) anlamlı olarak daha yüksekti. Neu/lym oranı, TE hastalarında AA grubundaki hastalara göre anlamlı olarak daha yüksekti (p=0,005). Sonuç: Tüm non-skatrisyel alopesilerin çok yüksek bir yüzdesinde D vitamini eksikliği görüldü. Neu/lym oranı TE'li hastalar için diğer non-skatrisyel alopesilerden daha uygun bir inflamatuar belirteç olabilir.

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Cite This Article

Şereflican, B., Dilcan, M., Polat, M. (2025). Evaluation of Vitamin D and Hematological Parameters in Pediatric Non-Scarring Alopecias. Düzce Tıp Fakültesi Dergisi, Volume: 27 Issue: 1. https://doi.org/10.18678/dtfd.1579685

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References (33)

  1. Mounsey AL, Reed SW. Diagnosing and treating hair loss. Am Fam Physician. 2009;80(4):356-62.
  2. Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The role of vitamins and minerals in hair loss: a review. Dermatol Ther (Heidelb). 2019;9(1):51-70.
  3. Conic RRZ, Piliang M, Bergfeld W, Atanaskova-Mesinkovska N. Vitamin D status in scarring and nonscarring alopecia. J Am Acad Dermatol. 2021;85(2):478-80.
  4. Chen Y, Dong X, Wang Y, Li Y, Xiong L, Li L. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis. J Cosmet Dermatol. 2024;23(4):1131-40.
  5. Wang Q, Ma J, Jiang Z, Ming L. Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute pulmonary embolism: a systematic review and meta-analysis. Int Angiol. 2018;37(1):4-11.
  6. Trüeb RM. Telogen effluvium: Is there a need for a new classification? Skin Appendage Disord. 2016;2(1-2):39-44.
  7. Peyravian N, Deo S, Daunert S, Jimenez JJ. The inflammatory aspect of male and female pattern hair loss. J Inflamm Res. 2020;13:879-81.
  8. Zhang B, Zhao Y, Cai Z, Caulloo S, McElwee KJ, Li Y, et al. Early-stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum. Australas J Dermatol. 2013;54(3):184-91.
  9. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
  10. Kechichian E, Ezzedine K. Vitamin D and the skin: An update for dermatologists. Am J Clin Dermatol. 2018;19(2):223-35.
  11. Gade VKV, Mony A, Munisamy M, Chandrashekar L, Rajappa M. An investigation of vitamin D status in alopecia areata. Clin Exp Med. 2018;18(4):577-84.
  12. Bhat YJ, Latif I, Malik R, Hassan I, Sheikh G, Lone KS, et al. Vitamin D level in alopecia areata. Indian J Dermatol. 2017;62(4):407-10.
  13. Oğrum A, Boyraz N, Karataş Toğral A, Karasatı S, Ekşioğlu HM. Evaluation of 25 hydroxy vitamin D3 levels in patients with alopecia areata. Turk Arch Dermatol Venereol. 2015;49(1):50-3. Turkish.
  14. Thompson JM, Li T, Park MK, Qureshi AA, Cho E. Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women. Arch Dermatol Res. 2016;308(9):671-6.
  15. Liu Y, Li J, Liang G, Cheng C, Li Y, Wu X. Association of alopecia areata with vitamin D and calcium levels: A systematic review and meta-analysis. Dermatol Ther (Heidelb). 2020;10(5):967-83.
  16. Lin X, Meng X, Song Z. Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. Am J Transl Res. 2019;11(9):5285-5300.
  17. Siddappa H, Kumar YHK, Neladimmanahally V. Evaluation of vitamin D in pediatric alopecia areata: a case-control study of thirty patients in a tertiary care hospital. Indian J Paediatr Dermatol. 2019;20(1):32-5.
  18. Kundak S, Kutlu A. Serum 25-hydroxy-vitamin D and vitamin B12 levels in childhood alopesia areata. J Dr Behcet Uz Child Hosp. 2021;11(1):101-7.
  19. Lim RK, Castelo-Soccio L, Putterman E, Qureshi AA, Cho E. Predictors of vitamin D insufficiency in children and adolescents with alopecia areata. Cureus. 2022;14(3):e22934.
  20. Unal M, Gonulalan G. Serum vitamin D level is related to disease severity in pediatric alopecia areata. J Cosmet Dermatol. 2018;17(1):101-4.
  21. Tran PT, Chen A, Yi L, Goh C. Vitamin D levels in alopecia areata and other alopecias: A retrospective case-control study at a single institution. Int J Trichology. 2022;14(5):175-7.
  22. Öner Ü, Akdeniz N. Nonscarring scalp alopecia: Which laboratory analysis should we perform on whom? Turk J Med Sci. 2022;52(1):188-94.
  23. Gomes TF, Soares RO. Pediatric androgenetic alopecia: an updated review. J Dtsch Dermatol Ges. 2023;21(1):19-25.
  24. Losoya-Jaquez MR, Lopez Yañez-Blanco A, Armendariz-Barragan Y, Aguilar-Figueroa NG, Rudnicka L, Sanchez-Dueñas LE. Androgenetic alopecia in children and adolescents: From trichoscopy to therapy. Skin Appendage Disord. 2024;10(2):123-8.
  25. Rasheed H, Mahgoub D, Hegazy R, El-Komy M, Abdel Hay R, Hamid MA, et al. Serum ferritin and vitamin D in female hair loss: Do they play a role? Skin Pharmacol. Physiol. 2013;26(2):101-7.
  26. Nayak, K, Garg A, Mithra P, Manjrekar P. Serum vitamin D3 levels and diffuse hair fall among the student population in South India: A case-control study. Int J Trichology. 2016;8(4):160-4.
  27. Karadag AS, Ertugrul DT, Tutal E, Akin KO. The role of anemia and vitamin D levels in acute and chronic telogen effluvium. Turk J Med Sci. 2011;41(5): 827-33.
  28. Chen V, Strazzulla L, Asbeck SM, Bellodi Schmidt F. Etiology, management, and outcomes of pediatric telogen effluvium: A single-center study in the United States. Pediatr Dermatol. 2023;40(1):120-4.
  29. Işıktaş Sayılar E, Çelik S, İnce ME, Ergün İ. The post-transplant neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in relation to graft function among renal transplant recipients. Duzce Med J. 2020;22(3):212-7.
  30. İslamoğlu ZGK, Demirbaş A. Evaluation of complete blood cell and inflammatory parameters in patients with alopecia areata: Their association with disease severity. J Cosmet Dermatol. 2020;19(5):1239-45.
  31. Dere G, Gündoğdu M. Investigation of the relationship between alopecia areata and inflammatory blood parameters. J Cosmet Dermatol. 2021;20(12):4048-51.
  32. Aksoy Sarac G, Acar O, Nayır T, Hararcı Yıldırım P, Dinçer Rota D. The use of new hematological markers in the diagnosis of alopecia areata. Dermatol Pract Concept. 2023;13(2):e2023118.
  33. El-Taweel A, Mustafa A, Abd El-Halim W, Roshdy A. Blood indices in patients with androgenetic alopecia. Benha J Appl Sci. 2020;5(5):269-72.