Journals / Journal of Emergency Medicine Case Reports / 2026 / Cilt: 14 Sayı: 2

A Case Report of Metformin Related Lactic Acidosis

İlker Akbaş(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6676-6517
Caner Akufuk(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-4624-0803
Muhammet Mustafa Yılmaz(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8952-6329
Atilla Eren Kurt(MARMARA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0009-3853-6699
Fatih Coşkun(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, BURSA YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-0541-5910
Pages
44–45
Publication Date
2023-07-07
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this case report, we present the early diagnosis and successful treatment of a patient with lactic acidosis due to metformin intoxication.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Metformin is an oral antidiabetic drug of the biguanide classused in type 2 diabetic patients with normal renal function.
📊
Key Findings & Data:The mortality rate is high in cases of lactic acidos is developing in metformin intoxication.
💡
Conclusion & Impact:In this case report, we present the early diagnosis and successful treatment of a patient with lactic acidosis due to metformin intoxication.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Metformin · Poisoning · Lactic acidosis

Abstract

Metformin is an oral antidiabetic drug of the biguanide classused in type 2 diabetic patients with normal renal function. The mortality rate is high in cases of lactic acidos is developing in metformin intoxication. In the emergency department, metformin intoxication should be considered in the differential diagnosis of patients whouse metformin and have high anion gap metabolic acidosis (lactic acidosis). The most important and effective treatment with early diagnosis is correction of metabolic acidosis with hemodialysis or hemofiltration methods, bicarbonate treatment, adjustment of blood glucose level. Cardiovascular system support therapy significantly reduces morbidity/mortality. In this case report, we present the early diagnosis and successful treatment of a patient with lactic acidosis due to metformin intoxication.

🔖

Cite This Article

Akbaş, İ., Akufuk, C., Yılmaz, M. M., Kurt, A. E., Coşkun, F. (2023). A Case Report of Metformin Related Lactic Acidosis. Journal of Emergency Medicine Case Reports, Cilt: 14 Sayı: 2, 44–45. https://doi.org/10.33706/jemcr.1294738

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Çakmak F. Demographic Characteristics of Patients Applied to The Emergency Service with Drug Intoxications. Eurasian Journal of Toxicology. 2020; 2(3): 68-70.
  2. Balkan, B., Demir, G., Balkan, F., Çetingök, H. &Atiç, E. (2020). Metformin İlişkili Laktik Asidoz; Bir Olgu Nedeni İle Literatürün Gözden Geçirilmesi. Tıp Fakültesi Klinikleri Dergisi. 3 (1), 49-53.
  3. Çağla Patır, D., Köseli, İ., Engin, B. & Akar, H. (2019). Metformin intoksikasyonuna bağlı gelişen nadir bir birliktelik şiddetli laktik asidoz ve akut pankreatit: Olgu sunumu. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 4 (4), 197-199.
  4. Aydar, H., Tezcan, N. & Mutluay, R. (2022). Metformin intoksikasyonuna sekonder gelişen akut böbrek hasarı ve laktik asidoz. Pamukkale Medical Journal, 15 (2), 379-382. DOI: 10.31362/patd.900939
  5. Eren, E., Türe, M., Almaz, V., Bilgiç, T., Yıldırım, İ. & Gider, T. (2012). Bir ergende metformin zehirlenmesi. Türk Pediatri Arşivi, 47 (4), 313-314. DOI: 10.4274/tpa.1004
  6. Çelebi K., Ahmet Ö. Acute Renal Failure Due to Metformin Intoxication: Case Report. J Turk Soc Intensive Care. 2018; 16: 76-78
  7. Gedik M. S., Hakkoymaz H., Kilci A. İ., Küçük Ö. F. General Approach to Cases of Drug Intoxication. Eurasian Journal of Critical Care. 2023; 5(1): 17-21.
  8. Sener K, Arslan B, Ozselcuk S, Guven R. Resistant Lactic Acidemia Due to Accidental Cheese Starter Culture Ingestion. American Journal of Emergency Medicine. 2022;60: 228.e1-228.e2
  9. Wills BK., Bryant SM., Buckley P., Seo B. Can acute over dose of metformin lead to lactic acidosis? Am J EmergMed. 2010; 28: 857-861.
  10. Li Cavoli G.,Tortorici C., Bono L., Giammarresi C., Ferrantelli A., Zagarrigo C., et al. Acute kidney injury associated with metformin. Am J EmergMed. 2011; 29: 568-569.
  11. Mustafa E., Lai L., Lien YH. Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia. Am J Med. 2012; 125: 1-2.
  12. Acquistapace G., Rossi M., Garbi M., Cosci P., Canetta C., Manelli A., et al. Acute metformin intoxication: 2012 experience of Emergency Departement of Lodi, Italy. Clin Chem Lab Med. 2014; 52: 1489-97.
  13. Balkan, B., Demir, G., Balkan, F., Çetingök, H. &Atiç, E. (2020). Metformin İlişkili Laktik Asidoz; Bir Olgu Nedeni İle Literatürün Gözden Geçirilmesi. Tıp Fakültesi Klinikleri Dergisi. 3 (1), 49-53.
  14. Çağla Patır, D., Köseli, İ., Engin, B. & Akar, H. (2019). Metformin intoksikasyonuna bağlı gelişen nadir bir birliktelik şiddetli laktik asidoz ve akut pankreatit: Olgu sunumu. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 4 (4), 197-199.
  15. Aydar, H., Tezcan, N. & Mutluay, R. (2022). Metformin intoksikasyonuna sekonder gelişen akut böbrek hasarı ve laktik asidoz. Pamukkale Medical Journal, 15 (2), 379-382. DOI: 10.31362/patd.900939
  16. Eren, E., Türe, M., Almaz, V., Bilgiç, T., Yıldırım, İ. & Gider, T. (2012). Bir ergende metformin zehirlenmesi. Türk Pediatri Arşivi, 47 (4), 313-314. DOI: 10.4274/tpa.1004
  17. Gedik M. S., Hakkoymaz H., Kilci A. İ., Küçük Ö. F. General Approach to Cases of Drug Intoxication. Eurasian Journal of Critical Care. 2023; 5(1): 17-21.