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Journals / Sigma Mühendislik ve Fen Bilimleri Dergisi / 2026 / Volume: 42 Issue: 2

The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

Emel Serdaroğlu Kaşikçi(Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University, Üsküdar, İstanbul, 34662, Türkiye)0000-0003-1566-5788
Burcu Çevreli(Üsküdar University, Neuropsychopharmacology Research and Application Center, Üsküdar, İstanbul, 34662, Türkiye)0000-0001-6337-4999
Tayfun Gözler(Üsküdar University, Neuropsychopharmacology Research and Application Center, Üsküdar, İstanbul, 34662, Türkiye)0000-0001-8548-8516
Muhsin Konuk(Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University, Üsküdar, İstanbul, 34662, Türkiye)
Pages
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Publication Date
2024-04-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

📌 3 Key Takeaways

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Objective & Hypothesis:This study evaluates the protective effect of Hesperidin (HES), flavanoglycone, during pre-ec-lampsia developed pregnancy.
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Key Findings & Data:The pregnant rats were randomly divided into five groups as Control, L-NAME (25 mg/kg), HES (100 mg/kg), L-NAME-HES and L-NAME P-HES.
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Conclusion & Impact:Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hesperidin · Pre-Eclampsia · Oxidative Damage

Abstract

This study evaluates the protective effect of Hesperidin (HES), flavanoglycone, during pre-ec-lampsia developed pregnancy. The pregnant rats were randomly divided into five groups as Control, L-NAME (25 mg/kg), HES (100 mg/kg), L-NAME-HES and L-NAME P-HES. After the 13th day of pregnancy, the chemicals were administrated until the 20th day. 20 days after the offspring’s birth, they were separated from their mothers and all rats were sacrificed after 6 weeks’ time. Serum samples were analyzed for levels of Glutathione (GSH), lipid peroxidation (LPO), and neuron-specific enolase (NSE) activity. Urine samples were analyzed for the pro-teinuria. While Proteinuria and LPO level increasing, GSH levels decreased in the L-NAME group when compared to the Control. As we compared L-NAME group with the L-NAME-HES and L-NAME P-HES groups, the GSH levels increased significantly while LPO levels in the HES, L-NAME-HES, L-NAME P-HES groups were decreasing. The NSE activity signifi-cantly increased in the L-NAME group compared to the Control. In contrast to the L-NAME group, its activity decreased in HES, L-NAME-HES and L-NAME P-HES groups significantly. Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

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Cite This Article

Kaşikçi, E. S., Çevreli, B., Gözler, T., Konuk, M. (2024). The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model. Sigma Mühendislik ve Fen Bilimleri Dergisi, Volume: 42 Issue: 2. https://ajindex.com/articles/1344541

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