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Journals / Sinop Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 7 Sayı: 1

Synthesis and Characterization of Proton Salts of Sulfanilamide Containing Maleic Acid and Aminopyridine Derivatives

Sülfanilamit İçeren Maleik Asit ile Aminopiridin Türevlerinin Proton Tuzlarının Sentezi ve Karakterizasyonu

Halil İlkimen(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0000-0003-1747-159X
Cengiz Yenikaya(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ)0000-0002-5867-9146
Pages
57–70
Publication Date
2022-06-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the results of this analysis, the acid:base ratio of salts was found to be 1:1.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, maleic acid containing sulfanilamide (E)-3-(4-sulfamoylphenylcarbamoyl) acrylic acid (1) was synthesized from the reaction of maleic anhydride (mal) and sulfanilamide (sa) with the method found in the literature.
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Key Findings & Data:Then, proton transfer salts (6-9) were obtained.
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Conclusion & Impact:According to the results of this analysis, the acid:base ratio of salts was found to be 1:1.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:(E)-3-(4-sülfamoyilfenilkarbamoil)akrilik asit · Aminopiridinler · Proton Transfer Tuzu

Abstract

In this study, maleic acid containing sulfanilamide (E)-3-(4-sulfamoylphenylcarbamoyl) acrylic acid (1) was synthesized from the reaction of maleic anhydride (mal) and sulfanilamide (sa) with the method found in the literature. Then, proton transfer salts (6-9) were obtained. The structures of the obtained salts were suggested by elemental analysis, 1H and 13C Nuclear Magnetic Resonance Spectroscopy (NMR), Fourier Transform Infrared Spectroscopy (FT- IR) and charge balance. According to the results of this analysis, the acid:base ratio of salts was found to be 1:1. In this study, it was aimed to synthesize chemical substances that can be dissolved in water and have different activity properties.

Özet

Bu çalışmada önce literatürde bulunan yöntemle maleik anhidrit (mal) ile sülfanilamitin (sa) tepkimesinden sülfanilamit içeren maleik asit olan (E)-3-(4-sülfamoilfenilkarbamoil) akrilik asit (1) sentezlenmiştir. Daha sonra 1 ile 2-amino-6-metilpiridin (2), 2-amino-5-metilpiridin (3), 2-amino-4-metilpiridin (4) ve 3-aminopiridin (5) tepkimesinden proton transfer tuzları (6-9) elde edilmiştir. Elde edilen tuzların yapıları, elementel analiz, 1H ve 13C Nükleer Manyetik Rezonans Spektroskopisi (NMR), Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR) ve yük denkliği ile önerilmiştir. Bu analiz sonuçlarına göre tuzlarda asit:baz oranı 1:1 olarak bulunmuştur. Bu çalışmada, suda çözülebilen ve farklı aktivite özellikleri gösterebilecek kimyasal madde sentezi hedeflenmiştir.

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Cite This Article

İlkimen, H., Yenikaya, C. (2022). Synthesis and Characterization of Proton Salts of Sulfanilamide Containing Maleic Acid and Aminopyridine Derivatives. Sinop Üniversitesi Fen Bilimleri Dergisi, Cilt: 7 Sayı: 1, 57–70. https://doi.org/10.33484/sinopfbd.1069649

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