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Journals / Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi / 2025 / Cilt: 16 Sayı: 3

An Overview of Drug-loaded Contact Lenses

İlaç Yüklü Kontakt Lenslere Genel Bakış

Heybet Kerem Polat(Türkiye İlaç ve Tıbbi Cihaz Kurumu)0000-0001-5006-3091
Nasıf Fatih Karakuyu(SULEYMAN DEMIREL UNIVERSITY, FACULTY OF PHARMACY)0000-0002-2249-4668
Pages
433–445
Publication Date
2025-12-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The preparation techniques, in vitro and in vivo research, and future possibilities for drug-loaded contact lenses are all evaluated in this review of the most recent developments in the treatment of ocular illnesses.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Within the scope of this review, contact lens types designed for the treatment of ocular diseases, different drug loading methods, and in vitro and in vivo studies performed after drug loading are examined.
📊
Key Findings & Data:Result and Discussion: Topical ocular dosage forms have numerous problems, including low bioavailability, poor patient compliance, and potential side effects.
💡
Conclusion & Impact:The preparation techniques, in vitro and in vivo research, and future possibilities for drug-loaded contact lenses are all evaluated in this review of the most recent developments in the treatment of ocular illnesses.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Göz · Oküler Sistem · Kontakt Lens

Abstract

Objective: Within the scope of this review, contact lens types designed for the treatment of ocular diseases, different drug loading methods, and in vitro and in vivo studies performed after drug loading are examined. Result and Discussion: Topical ocular dosage forms have numerous problems, including low bioavailability, poor patient compliance, and potential side effects. Innovative ocular drug delivery systems are being studied to overcome the limitations associated with traditional formulations. One of these systems is drug-loaded contact lenses, which prolong the duration of drug retention in the eye and reduce the occurrence of side effects. Drug-loaded contact lenses have been effectively manufactured using a variety of techniques, including dipping, molecular imprinting, supercritical fluid nanosystems, and vitamin E modification technologies. These techniques have also proved successful in extending the drug's release period. The preparation techniques, in vitro and in vivo research, and future possibilities for drug-loaded contact lenses are all evaluated in this review of the most recent developments in the treatment of ocular illnesses.

Özet

Amaç: Bu derleme kapsamında oküler hastalıkaların tedavisi için tasarlanan kontakt lens tipleri, bu kontakt lenslere ilaç yükleme yöntemleri ve ilaç yüklemesi sonrası yapılan in vitro ve in vivo çalışmalar incelenmiştir. Sonuç ve Tartışma: Topikal oküler ilaçların; düşük biyoyararlanım, zayıf hasta uyuncu ve yüksek yan etki oluşma ihtimali gibi pek çok sorunu bulunmaktadır. Klasik formülasyonlarla ilişkili sınırlamaların üstesinden gelmek için yeni oküler ilaç taşıyıcı sistemler geliştirmek üzere çalışmalar yapılmaktadır. Bu sistemlerden birisi de ilaçların gözde kalış süresini uzatan, yan etki oluşumunu azaltan bir sistem olan ilaç yüklü kontakt lenslerdir. İlaç yüklü kontakt lenslere; daldırma, moleküler baskılama, nanosistemler, E vitamini değişimi ve süperkritik sıvı teknolojisi gibi çeşitli yöntemler başarıyla uygulanmış ve ilaçların salım süresi uzatılmıştır. Bu yayında, ilaç yüklü kontakt lenslerin hazırlanma yöntemleri, yapılan in vitro ve in vivo çalışamaları ve geleceğe yönelik beklentiler de dahil olmak üzere oküler hastalıkların tedavisindeki son gelişmeler değerlendirilmektedir.

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Cite This Article

Polat, H. K., Karakuyu, N. F. (2025). An Overview of Drug-loaded Contact Lenses. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 16 Sayı: 3, 433–445. https://doi.org/10.22312/sdusbed.1573846

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