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Journals / The European Research Journal / 2026 / Volume: 7 Issue: 1

Reliability of cavernous sinus sampling in management of Cushing’s disease

Mahmut Çamlar(Department of Neurosurgery, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey)0000-0002-6467-0172
Burak Kınalı(Department of Neurosurgery, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey)0000-0002-1124-6888
Necmettin Tanrıöver(Department of Neurosurgery, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey)0000-0001-7628-9443
Pınar Kadıoğlu(Department of Internal Medicine, Division of Endocrinology-Metabolism and Diabetes, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey)0000-0002-8329-140X
Seçil Erden(Department of Fundamentals of Nursing, İstanbul University-Cerrahpaşa, Florance Nightingale Faculty of Nursing, İstanbul, Turkey)0000-0002-4931-3599
Civan Islak(Department of Neuroradiology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey)0000-0002-3626-6244
Naci Kocer(Department of Neuroradiology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey)0000-0003-0884-6492
Osman Kızılkılıc(Department of Neuroradiology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey)0000-0002-6620-8934
Meryem Ören(Department of Public Health Services Presidency, Erzurum Provincial Health Directorate, Erzurum, Turkey)0000-0002-3383-7830
Nurperi Gazioğlu(Department of Neurosurgery, İstanbul Bilim University School of Medicine, İstanbul, Turkey)0000-0001-7785-8628
Pages
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Publication Date
2021-01-04
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Our results showed that CSS is a safe and reliable method for microadenomas which has high diagnostic accuracy (80%) in indicating the correct lateralization in CD, providing us higher remission rates in a challenging pathology.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The purpose of this study is to find out the accuracy of bilateral cavernous sinus sampling (CSS) for preoperative tumor lateralization within the pituitary in Cushing’s disease (CD).
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Key Findings & Data:Methods: Sixty-five patients who had undergone transsphenoidal surgery (TSS) following CSS for CD between 2000-2016 at our institution were analyzed retrospectively.
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Conclusion & Impact:Conclusions: Our results showed that CSS is a safe and reliable method for microadenomas which has high diagnostic accuracy (80%) in indicating the correct lateralization in CD, providing us higher remission rates in a challenging pathology.
🔬Design:Research Article
📍Scope:2000-2016 Verileri
⚙️Variables:Cushing’s disease · pituitary tumor · Adrenocorticotropic hormone

Abstract

Objectives: The purpose of this study is to find out the accuracy of bilateral cavernous sinus sampling (CSS) for preoperative tumor lateralization within the pituitary in Cushing’s disease (CD). Methods: Sixty-five patients who had undergone transsphenoidal surgery (TSS) following CSS for CD between 2000-2016 at our institution were analyzed retrospectively. All patients underwent bilaterally CSS with corticotropin-releasing hormone (CRH) stimulation. Radiological, preoperative, and pathological findings with remission status were correlated with CSS data. The accuracy of CSS is decided according to compliance with the magnetic resonance imaging (MRI), pathology or remission after surgery of the normal MRI cases. Results: CSS indicated the correct lateralization in 52 (80%) patients. There was the same level elevation of both sides in 3 patients who had central adenoma. Remission rate in the final follow-up was 83.87% for 65 patients. We found out the contralateral pathological side in 13 (20%) of the patients showing false lateralization. Twenty-four patients with normal MRI had a positive accuracy rate of 83%. Of those patients, with a positive accuracy of CSS sampling, 18 (90%) had a positive remission. As a result of the Kappa analysis, statistically significance and relation was found between the final diagnosis and lateralization test (κ=0,63 p < 0.001). Conclusions: Our results showed that CSS is a safe and reliable method for microadenomas which has high diagnostic accuracy (80%) in indicating the correct lateralization in CD, providing us higher remission rates in a challenging pathology.

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Cite This Article

Çamlar, M., Kınalı, B., Tanrıöver, N., Kadıoğlu, P., Erden, S., Islak, C., Kocer, N., Kızılkılıc, O., Ören, M., Gazioğlu, N. (2021). Reliability of cavernous sinus sampling in management of Cushing’s disease. The European Research Journal, Volume: 7 Issue: 1. https://doi.org/10.18621/eurj.763928

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