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Journals / The European Research Journal / 2026 / Volume: 8 Issue: 4

Effect of metaclopramide on urinary bladder smooth muscle contraction-relaxation mechanism

Zübeyde Ercan(Department of Physiotherapy and Rehabilitation, Firat University, Faculty of Health Sciences, Elazig, Turkey)0000-0002-5294-8771
Gökhan Zorlu(Department of Biopysics, Firat University, Faculty of Medicine, Elazig, Turkey)0000-0002-6453-9772
Özgür Bulmuş(Department of Physiology, Balikesir University, Faculty of Medicine, Balikesir, Turkey)0000-0001-7736-402X
İhsan Serhatlıoğlu(Department of Biopysics, Firat University, Faculty of Medicine, Elazig, Turkey)0000-0002-2384-7971
Abdullah Yaşar(Vocational School of Health Services, Firat University, Elazig, Turkey)0000-0002-1277-5976
Emine Kacar(Department of Physiology, Firat University, Faculty of Medicine, Elazig, Turkey)0000-0002-1585-7248
Pages
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Publication Date
2022-07-04
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This effect should be taken into consideration in clinical use, especially when used in urinary system infections.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Metoclopramide, a dopamine receptor antagonist, a benzamide, is a commonly used antiemetic drug in many diseases with nausea and vomiting.
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Key Findings & Data:The effect of metoclopramide at concentrations of 10 µM and 20 µM on sections where spontaneous contractions were observed under 1.5 g of tension was investigated.
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Conclusion & Impact:This effect should be taken into consideration in clinical use, especially when used in urinary system infections.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Metoclopramide · urinary bladder · isometric contraction

Abstract

Objectives: Metoclopramide, a dopamine receptor antagonist, a benzamide, is a commonly used antiemetic drug in many diseases with nausea and vomiting. The aim of this study is to examine the effects of metoclopramide, which is also used in urinary system infections, on the urinary bladder contraction-relaxation mechanism. Methods: In the study, bladder tissue strips obtained from adult female Wistar rats in diestrus were placed in an isolated organ bath containing Krebs solution. The effect of metoclopramide at concentrations of 10 µM and 20 µM on sections where spontaneous contractions were observed under 1.5 g of tension was investigated. Results: Metaclopramide caused a statistically significant increase in the area under the contraction curve (AUC) and peak to peak (p-p) parameters of spontaneous bladder contractions at concentrations of 10 and 20 μM ( p < 0.01). Conclusions: Metaclopramide has an activator effect on spontaneous bladder contractions. This effect should be taken into consideration in clinical use, especially when used in urinary system infections.

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Cite This Article

Ercan, Z., Zorlu, G., Bulmuş, Ö., Serhatlıoğlu, İ., Yaşar, A., Kacar, E. (2022). Effect of metaclopramide on urinary bladder smooth muscle contraction-relaxation mechanism. The European Research Journal, Volume: 8 Issue: 4. https://doi.org/10.18621/eurj.945752

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