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Journals / The European Research Journal / 2026 / Volume: 9 Issue: 3

GSTM1, GSTP1, p53 as some probable predictors of prognosis in primary and metastatic epithelial ovarian cancer

Gizem Özer(Department of Biology, Kırıkkale University, Faculty of Art and Sciences, Kırıkkale, Turkey)0000-0003-3288-0965
Pınar Kaygın(Department of Biology, Kırıkkale University, Faculty of Art and Sciences, Kırıkkale, Turkey)0000-0003-0127-1753
Onur Dirican(Department of Pathology Laboratory Techniques, Istanbul Gelişim University, Vocational School of Health Services, Istanbul, Turkey)0000-0003-0511-6611
Serpil Oğuztüzün(Department of Biology, Kırıkkale University, Faculty of Art and Sciences, Kırıkkale, Turkey)0000-0002-5892-3735
Sezen Yılmaz Sarıaltın(Department of Pharmaceutical Toxicology, Ankara University, Faculty of Pharmacy, Ankara, Turkey)0000-0002-8387-4146
Gülçin Güler Şimşek(Department of Pathology, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey)0000-0001-7710-4631
Ayşegül Erdem(Department of Pathology, University of Health Sciences, Keçiören Training and Research Hospital, Ankara, Turkey)0000-0002-5222-5928
Murat Kılıç(Department of Pharmacy Services, Ankara University, Vocational School of Health Services, Ankara, Turkey)0000-0002-1377-2021
Tülay Çoban(Department of Pharmaceutical Toxicology, Ankara University, Faculty of Pharmacy, Ankara, Turkey)0000-0002-9696-6613
Pages
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Publication Date
2023-05-04
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies with more cases are required to confirm the results of our present study.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Ovarian carcinomas are responsible for the death of more women than all other gynecologic malignancies in the Western world.
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Key Findings & Data:Ovarian carcinomas are detected in an advanced stage of the disease in approximately 80% of the patients.
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Conclusion & Impact:Further studies with more cases are required to confirm the results of our present study.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ovary carcinoma · glutathione-S-transferase · p53

Abstract

Objectives: Ovarian carcinomas are responsible for the death of more women than all other gynecologic malignancies in the Western world. Ovarian carcinomas are detected in an advanced stage of the disease in approximately 80% of the patients. Glutathione S-transferases (GSTs) are an important family involved in the detoxification of several xenobiotics. Thus, this mechanism protects tissues from the harmful effects of oxidative stress and chemical-induced damages. The expression of them may contribute to the characteristics of ovarian carcinoma as they can metabolise both exogenous and endogenous compounds, which are implicated in the development of ovarian cancer. Therefore, our aim was to determine the expressions of GST Mu 1 (GSTM1), GST Pi 1 (GSTP1), and also p53, which is a tumor suppressor gene, in benign and malign ovarian tumors and metastasis tissues. Methods: A total of the 99 patients with ovarian tumor enrolled in the study. Thirty-one of the tissues was benign tumor, 17 was malign tumor and 51 was metastasis. The immunohistochemical GSTM1, GSTP1, and p53 staining characteristics of these tissues were investigated. Results: The highest GSTM1, GSTP1, and p53 expression was noted in the malignant group followed by the metastasis group. GSTP1 expression was significantly higher in malignant tissues than benign ones ( p = 0.015). No statistically significant difference was observed in the level of GSTM1 expression between groups ( p = 0.524). p53 expression was significantly higher in the metastasis and malignant tissues than the benign ones ( p < 0.001). Conclusions: The higher expressions of GSTP1 and p53 in malignant and metastasis tissues than benign ones indicate that these expressions could be important biomarkers in ovarian cancer development and progression. Further studies with more cases are required to confirm the results of our present study.

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Cite This Article

Özer, G., Kaygın, P., Dirican, O., Oğuztüzün, S., Sarıaltın, S. Y., Şimşek, G. G., Erdem, A., Kılıç, M., Çoban, T. (2023). GSTM1, GSTP1, p53 as some probable predictors of prognosis in primary and metastatic epithelial ovarian cancer. The European Research Journal, Volume: 9 Issue: 3. https://doi.org/10.18621/eurj.1112116

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