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Journals / The European Research Journal / 2026 / Volume: 11 Issue: 2

Impact of colchicine on inflammatory markers and pregnancy outcomes in familial Mediterranean fever patients

Betül Tokgöz Çakır(Department of Perinatology, Ankara Etlik City Hospital, Ankara, Türkiye)0000-0003-0202-4981
Gizem Aktemur(Department of Perinatology, Ankara Etlik City Hospital, Ankara, Türkiye)0000-0001-6824-881X
Gülşan Karabay(Department of Perinatology, Ankara Etlik City Hospital, Ankara, Türkiye)0000-0003-2567-2850
Zeynep Şeyhanlı(Department of Perinatology, Ankara Etlik City Hospital, Ankara, Türkiye)0000-0003-3924-3723
Nazan Vanlı Tonyalı(Department of Perinatology, Ankara Etlik City Hospital, Ankara, Türkiye)0000-0002-7284-6887
Furkan Akın(Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara, Türkiye)0009-0004-4026-1974
Salime Nur Afsar(Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, Ankara, Türkiye)0009-0008-8691-1468
Şevki Çelen(Department of Perinatology, Ankara Etlik City Hospital, Ankara, Türkiye)0000-0001-7033-3474
Pages
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Publication Date
2025-03-04
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The aim of this study is to evaluate the effect of colchicine use on maternal inflammatory markers and pregnancy outcomes in pregnant women diagnosed with Familial Mediterranean Fever (FMF) and receiving colchicine therapy.
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Key Findings & Data:Methods: This retrospective analysis included 42 pregnant women diagnosed with FMF who underwent colchicine treatment and 126 healthy pregnant controls.
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Conclusion & Impact:Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Familial Mediterranean fever · colchicine · inflammation

Abstract

Objectives: The aim of this study is to evaluate the effect of colchicine use on maternal inflammatory markers and pregnancy outcomes in pregnant women diagnosed with Familial Mediterranean Fever (FMF) and receiving colchicine therapy. Methods: This retrospective analysis included 42 pregnant women diagnosed with FMF who underwent colchicine treatment and 126 healthy pregnant controls. Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratio (PLR), and Monocyte/Lymphocyte Ratio (MLR) rates in the blood of the groups in the first trimester, obstetric morbidities and pregnancy outcomes were compared. Results: The patient cohort had markedly reduced hemoglobin levels (12.15±1.36 vs. 12.80±1.02 g/dL, P=0.001), an elevated prevalence of anemia (19% vs. 3%, P=0.002), and diminished monocyte counts (0.55 vs. 0.61 ×10⁹/L, P=0.022) as well as decreased MLR values (0.27 vs. 0.29, P=0.020) in comparison to the control group. Other inflammatory markers, pregnancy complications, and neonatal outcomes were similar between the groups (p>0.05). Conclusions: Colchicine seems to be useful in managing inflammation during FMF pregnancies without negatively affecting pregnancy or neonatal outcomes. Thorough prenatal care, encompassing anemia monitoring, is crucial for enhancing mother and fetal health.

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Cite This Article

Çakır, B. T., Aktemur, G., Karabay, G., Şeyhanlı, Z., Tonyalı, N. V., Akın, F., Afsar, S. N., Çelen, Ş. (2025). Impact of colchicine on inflammatory markers and pregnancy outcomes in familial Mediterranean fever patients. The European Research Journal, Volume: 11 Issue: 2. https://doi.org/10.18621/eurj.1625889

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