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Journals / The European Research Journal / 2026 / Volume: 11 Issue: 4

The utilization of the large unstained cell (LUC) parameter in lymphoid, haematopoietic and related tissue’s malignant neoplasms

Gamze Gök(Department of Medical Biochemistry, Ankara Bilkent City Hospital, Ankara, Türkiye)0000-0002-2804-5548
Serpil Erdoğan(Department of Medical Biochemistry, Ankara Bilkent City Hospital, Ankara, Türkiye)0000-0002-4234-8094
Erbay Asutay(Department of Medical Biochemistry, Bartın State Hospital, Bartın, Türkiye)0000-0002-9334-793X
Gülsen Yılmaz(Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University, Faculty of Medicine, Ankara, Türkiye)0000-0002-9630-3852
Özcan Erel(Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University, Faculty of Medicine, Ankara, Türkiye)0000-0002-2996-3236
Fatma Meriç Yılmaz(Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University, Faculty of Medicine, Ankara, Türkiye)0000-0002-8252-6975
Pages
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Publication Date
2025-07-04
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Prospective studies including patient and control groups may be useful in assessing LUC%.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Large unstained cells (LUCs) are a differential count parameter reported by routine hematology analysis, and LUC percentages (LUC%) reflect active lymphocytes and peroxidase-negative cells.
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Key Findings & Data:Methods: LUC analysis was performed with Siemens ADVIA® 2120 Hematology System.
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Conclusion & Impact:Prospective studies including patient and control groups may be useful in assessing LUC%.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Large unstained cells (LUCs) · Siemens ADVIA 2120 · complete blood cell count

Abstract

Objectives: Large unstained cells (LUCs) are a differential count parameter reported by routine hematology analysis, and LUC percentages (LUC%) reflect active lymphocytes and peroxidase-negative cells. We aimed the evaluate the LUC% parameter in routine practice towards malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic, and related tissue. Methods: LUC analysis was performed with Siemens ADVIA® 2120 Hematology System. Data were obtained from Ankara Bilkent City Hospital’s laboratory information system. Results: A statistical difference in the LUC % data in the case of LUC % <4.5 and LUC % ≥4.5 among preliminary diagnoses was observed (P<0.001). According to the Kruskal-Wallis test, a statistical difference was observed between preliminary diagnosis and LUC % values (P<0.001). The One-way ANOVA test with Bonferroni correction was performed for post hoc multiple comparisons of the preliminary diagnosis among LUC%. LUC% was higher in Hodgkin Lymphoma patients than Myeloid leukaemia patients (P=0.002). LUC % was higher in the Lymphoid leukaemia patients than in the patients with Hodgkin lymphoma (P<0.001), Other and unspecified types of non-Hodgkin lymphoma (P<0.001), Multiple myeloma and malignant plasma cell neoplasms (P<0.001). LUC% was higher in patients with leukemia unspecified cell type than Hodgkin lymphoma (P<0.001), Follicular lymphoma (P<0.001), Non-follicular lymphoma (P<0.001), Mature T-Cell and Natural Killer Cell lymphomas (P<0.001), Other and unspecified types of non-Hodgkin lymphoma (P<0.001), Malignant immunoproliferative diseases (P<0.001), Multiple myeloma and malignant plasma cell neoplasms (P<0.001), Lymphoid leukaemia (P<0.001), Myeloid leukaemia (P<0.001), Other leukaemias of specified cell type patients (P<0.001). Conclusions: The present study underscores the importance of LUC% in line with ICD-10 and may provide ideas for new research. Prospective studies including patient and control groups may be useful in assessing LUC%.

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Cite This Article

Gök, G., Erdoğan, S., Asutay, E., Yılmaz, G., Erel, Ö., Yılmaz, F. M. (2025). The utilization of the large unstained cell (LUC) parameter in lymphoid, haematopoietic and related tissue’s malignant neoplasms. The European Research Journal, Volume: 11 Issue: 4. https://doi.org/10.18621/eurj.1625710

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