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Journals / The European Research Journal / 2025 / Volume: 11 Issue: 6

Cytological misdiagnosis of high-grade medullary thyroid carcinoma with papillary-like nuclear features: A case report

Ali Mızrak(Department of Medical Pathology, Sultangazi Haseki Training and Research Hospital, İstanbul, Türkiye)0000-0002-1096-1660
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Publication Date
2025-11-04
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Papillary carcinoma-like nuclear features may also be observed in medullary thyroid carcinoma and some cases could be mistakenly interpreted as papillary carcinoma in cytological examination.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Medullary thyroid carcinoma is an uncommon form of thyroid cancer that arises from the parafollicular C cells.
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Key Findings & Data:A 65-year-old female presented to the ear, nose, and throat department with a palpable neck mass.
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Conclusion & Impact:Papillary carcinoma-like nuclear features may also be observed in medullary thyroid carcinoma and some cases could be mistakenly interpreted as papillary carcinoma in cytological examination.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:Cytology · intranuclear pseudo inclusions · medullary thyroid carcinoma

Abstract

Medullary thyroid carcinoma is an uncommon form of thyroid cancer that arises from the parafollicular C cells. In this case report, a high-grade medullary thyroid carcinoma is discussed, which was initially diagnosed as papillary carcinoma due to the presence of papillary-like nuclear features in the cytological evaluation. A 65-year-old female presented to the ear, nose, and throat department with a palpable neck mass. Based on the cytological features of the fine needle aspiration (FNA), a diagnosis of 'malignant, papillary carcinoma', (Bethesda category 6) was made. After surgery, histological and immunohistochemical results led to a diagnosis of medullary thyroid carcinoma. Papillary carcinoma-like nuclear features may also be observed in medullary thyroid carcinoma and some cases could be mistakenly interpreted as papillary carcinoma in cytological examination.

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Cite This Article

Mızrak, A. (2025). Cytological misdiagnosis of high-grade medullary thyroid carcinoma with papillary-like nuclear features: A case report. The European Research Journal, Volume: 11 Issue: 6. https://doi.org/10.18621/eurj.1670211

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