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Journals / The Turkish Journal of Ear Nose and Throat / 2026 / Volume: 35 Issue: 1

Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome

Hamza Ogun(Bezmialem Vakif University, School of Medicine, Department of Chest Diseases)0000-0002-4799-9670
Eray Metin Güler(Health Sciences University, Hamidiye School of Medicine, Department of Medical Biochemistry)0000-0003-4351-1719
Beyza Nur Özkan(Health Sciences University, Hamidiye School of Medicine, Department of Medical Biochemistry)0000-0001-9707-9111
Muhammed Yunus Bektay(İstanbul University-Cerrahpaşa, Faculty of Pharmacy)0000-0003-2032-9957
Abdullah Kansu(İstanbul Medipol University, School of Medicine, Department of Chest Diseases)0000-0001-8902-5498
Ömer Faruk Çalım(İstanbul Medipol University, School of Medicine, Department of Otorhinolaryngology)0000-0002-0010-9028
Pages
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Publication Date
2025-03-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings confirm that oxidative stress and inflammation play significant roles in the pathophysi ology of OSA and offer new opportunities for diagnosis and monitoring.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate the relationship between obstructive sleep apnoea (OSA) severity and oxygen desaturation with biomarkers including ischaemia-modified albumin (IMA), interleukin-1β (IL-1β), thiol/ disulphide homeostasis parameters, and cardiac biomarkers (BNP, NT-proBNP).
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Key Findings & Data:Material and Methods: This cross-sectional study included 88 patients who underwent polysomnography at the Bezmialem Vakif University Sleep Laboratory.
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Conclusion & Impact:These findings confirm that oxidative stress and inflammation play significant roles in the pathophysi ology of OSA and offer new opportunities for diagnosis and monitoring.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Obstructive Sleep Apnoea · Biomarkers · Ischaemia-Modified Albumin

Abstract

Objective: To investigate the relationship between obstructive sleep apnoea (OSA) severity and oxygen desaturation with biomarkers including ischaemia-modified albumin (IMA), interleukin-1β (IL-1β), thiol/ disulphide homeostasis parameters, and cardiac biomarkers (BNP, NT-proBNP). Material and Methods: This cross-sectional study included 88 patients who underwent polysomnography at the Bezmialem Vakif University Sleep Laboratory. Participants were categorised into normal/mild OSA (n=36) and moderate/severe OSA (n=52) groups based on the apnoea-hypopnoea index (AHI). Blood samples were analysed for BNP, NT-proBNP, IMA, IL-1β, and thiol/disulphide homeostasis parameters. Results: The moderate/severe OSA group showed significantly higher levels of IMA (0.94±0.04 vs 0.88±0.04, p<0.001), IL-1β (359.82±121.14 vs 231.45±83.76 pg/mL, p<0.001), and lower levels of native thiol (345.23±69.85 vs 395.62±58.71 µmol/L, p<0.001) compared to the normal/mild group. BNP and NT-proBNP levels were moderately elevated in the moderate/severe OSA group (p=0.012 and p=0.003, respectively). Conclusion: IMA, IL-1β, and native thiol demonstrate promise as potential biomarkers for OSA severity. These findings confirm that oxidative stress and inflammation play significant roles in the pathophysi ology of OSA and offer new opportunities for diagnosis and monitoring.

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Cite This Article

Ogun, H., Güler, E. M., Özkan, B. N., Bektay, M. Y., Kansu, A., Çalım, Ö. F. (2025). Predictive Value of Natriuretic Peptide Tests and Ischemia Modified Albumin Levels in the Diagnosis of Obstructive Sleep Apnoea Syndrome. The Turkish Journal of Ear Nose and Throat, Volume: 35 Issue: 1. https://doi.org/10.26650/Tr-ENT.2025.1600469

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