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Journals / Turkish Journal of Clinics and Laboratory / 2026 / Cilt: 13 Sayı: 2

Investigation of the relationship of coronary artery diameters with prediabetes and diabetes in patients with first diagnosis acute coronary syndrome

İlk tanı akut koroner sendrom ile başvuran hastalarda koroner arter çaplarının prediyabet ve diyabet ile ilişkisinin incelenmesi

Yasin Özen(Sivas Numune Hastanesi)0000-0002-5379-249X
Özcan Özeke(Ankara Şehir Hastanesi)0000-0002-4770-8159
Mustafa Bilal Özbay(Metropolitan Hospital Center)0000-0003-2760-1028
Burak Açar(KOCAELI UNIVERSITY, KOCAELİ HEALTH ACADEMY)0000-0003-3217-5000
Mustafa Karakurt(Kırıkkale Yüksek İhtisas)0000-0002-9997-1178
Mevlüt Serdar Kuyumcu(SULEYMAN DEMIREL UNIVERSITY, ISPARTA HEALTH ACADEMY)0000-0003-1934-5773
Kadriye Gayretli Yayla(Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi)0000-0002-0664-9164
Çağrı Yayla(Ankara Şehir Hastanesi)0000-0002-5302-4052
Ahmet Ertem(Ankara Şehir Hastanesi)0000-0002-6963-6213
Dursun Aras(Ankara Şehir Hastanesi)0000-0001-6020-8098
Pages
242–252
Publication Date
2022-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Early diagnosis and treatment of prediabetes is important to provide a more suitable coronary lesion for percutaneous or surgical revascularization

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Diabetic patients have a more severe and widespread coronary atherosclerosis, and their coronary artery diameters (CADs) are widely affected, but this has not been evaluated in prediabetics.
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Key Findings & Data:We also found that the diameter of the LMCA was the most affected coronary segment, and the diameter of proximal LAD was second segment as affected mostly (p <0.001 for both).
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Conclusion & Impact:Early diagnosis and treatment of prediabetes is important to provide a more suitable coronary lesion for percutaneous or surgical revascularization
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:koroner arter çapları · HbA1c · prediyabet

Abstract

Aim: Diabetic patients have a more severe and widespread coronary atherosclerosis, and their coronary artery diameters (CADs) are widely affected, but this has not been evaluated in prediabetics. This study investigated the effects of prediabetes on CADs in patients with acute coronary syndrome. Material and Methods: Two hundred and sixty-six patients included in this study were divided into three groups as "normal", "prediabetic" and "diabetic". Patients' CADs were calculated via the quantitative coronary angiography technique. Coronary segments were measured from the designated regions. Results: We found that both prediabetes and diabetes had similar adverse effects on vessels except the proximal RCA, unlike the normal group. We also found that the diameter of the LMCA was the most affected coronary segment, and the diameter of proximal LAD was second segment as affected mostly (p <0.001 for both). When total CADs were analyzed, it was seen that distal coronary artery segments were more affected than proximal (p <0.001). Conclusion: This study showed that coronary artery diameters of prediabetic patients were affected similarly to patients with diabetes, and the narrowing of the distal coronary arteries was more affected than the proximal vessels. Early diagnosis and treatment of prediabetes is important to provide a more suitable coronary lesion for percutaneous or surgical revascularization

Özet

Amaç: Diyabetik hastalarda daha yaygın ve şiddetli koroner ateroskleroz vardır ve koroner arter çapları (KAÇ) yaygın olarak etkilenir, ancak bu durum prediyabetiklerde değerlendirilmemiştir. Bu çalışma, akut koroner sendromlu hastalarda prediyabetin KAÇ' ları üzerindeki etkilerini araştırdı. Gereç ve Yöntemler: Bu çalışmaya dahil edilen 266 hasta "normal", "prediyabetik" ve "diyabetik" olmak üzere üç gruba ayrıldı. Hastaların KAÇ' ları kantitatif koroner anjiyografi tekniği ile hesaplandı. Koroner segmentler belirlenen bölgelerden ölçüldü. Bulgular: Normal gruptan farklı olarak hem prediyabetin hem de diyabetin proksimal RCA dışında damarlar üzerinde benzer etkileri olduğunu bulduk. Ayrıca LMCA çapının en çok etkilenen koroner segment olduğunu ve proksimal LAD çapının en çok etkilenen ikinci segment olduğunu bulduk (her ikisi için p<0,001). Total KAÇ' ları incelendiğinde distal koroner arter segmentlerinin proximal koronerlere göre daha fazla etkilendiği görüldü (p<0,001). Sonuç: Bu çalışma, prediyabetik hastaların koroner arter çaplarının diyabet hastalarına benzer şekilde etkilendiğini ve distal koroner arterlerdeki daralmanın proksimal damarlara göre daha fazla etkilendiğini göstermiştir. Prediyabetin erken tanı ve tedavisinin, perkütan veya cerrahi revaskülarizasyon için daha uygun bir koroner lezyon sağlamak açısından önemlidir.

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Cite This Article

Özen, Y., Özeke, Ö., Özbay, M. B., Açar, B., Karakurt, M., Kuyumcu, M. S., Yayla, K. G., Yayla, Ç., Ertem, A., Aras, D. (2022). Investigation of the relationship of coronary artery diameters with prediabetes and diabetes in patients with first diagnosis acute coronary syndrome. Turkish Journal of Clinics and Laboratory, Cilt: 13 Sayı: 2, 242–252. https://doi.org/10.18663/tjcl.1113964

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