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Journals / Turkish Journal of Clinics and Laboratory / 2026 / Cilt: 16 Sayı: 2

Association between second trimester maternal hypothyroidism and congenital heart diseases in fetuses: a retrospective study

Maternal hipotiroidi ile fetal konjenital kalp hastalıkları arasındaki ilişki: retrospektif bir çalışma

Bekir Yukcu(Giresun Obstetric and Pediatric Disease Education and Research Hospital, Pediatric Cardiology Department)0000-0003-1661-7024
Mehmet Albayrak(Giresun Obstetric and Pediatric Disease Education and Research Hospital)0000-0002-2371-6437
Pages
322–329
Publication Date
2025-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The study suggests a potential association between maternal hypothyroidism and fetal CHD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: This study aimed to investigate the association between second-trimester maternal hypothyroidism and congenital heart diseases (CHDs) in fetuses.
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Key Findings & Data:Material and Methods: This retrospective study was conducted at Obstetrics and Pediatrics Training and Research Hospital between June 2022 and December 2024.
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Conclusion & Impact:Conclusion: The study suggests a potential association between maternal hypothyroidism and fetal CHD.
🔬Design:Araştırma Makalesi
📍Scope:2022 Verileri
⚙️Variables:Maternal hipotiroidizm · konjenital kalp hastalığı · fetal ekokardiyografi

Abstract

Aim: This study aimed to investigate the association between second-trimester maternal hypothyroidism and congenital heart diseases (CHDs) in fetuses. Material and Methods: This retrospective study was conducted at Obstetrics and Pediatrics Training and Research Hospital between June 2022 and December 2024. The patient group comprised mothers of children diagnosed with major CHDs, while the control group included mothers of children without CHDs or with minor anomalies not requiring intervention. Maternal thyroid status was determined by second-trimester TSH levels: >4.0 mIU/mL was classified as hypothyroid, while 0.2–4.0 mIU/mL was considered euthyroid. Statistical analyses, including ROC analysis, regression analysis, Chi-square test, Fisher's exact test, and Mann-Whitney U test, were performed using SPSS 25, with p 0.05). Conclusion: The study suggests a potential association between maternal hypothyroidism and fetal CHD.

Özet

Amaç: Bu çalışma, ikinci trimesterdeki maternal hipotiroidi ile fetal konjenital kalp hastalıkları (KKH) arasındaki ilişkiyi araştırmayı amaçladı. Gereç ve Yöntemler: Bu retrospektif çalışma, Haziran 2022 ile Aralık 2024 tarihleri arasında Kadın Doğum ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi'nde gerçekleştirildi. Hasta grubu, majör konjenital kalp hastalığı tanısı alan çocukların annelerinden oluşurken, kontrol grubu KKH olmayan veya müdahale gerektirmeyen minör anomalilere sahip çocukların annelerini içeriyordu. Annelerin tiroid durumu, ikinci trimesterde ölçülen TSH seviyelerine göre belirlendi: >4,0 mIU/mL hipotiroid, 0,2–4,0 mIU/mL ötiroid olarak kabul edildi. İstatistiksel analizler arasında ROC analizi, regresyon analizi, Ki-kare testi, Fisher'ın kesin testi ve Mann-Whitney U testi yer almakta olup, tüm analizler SPSS 25 kullanılarak gerçekleştirildi ve p 0,05). Sonuç: Çalışma, maternal hipotiroidizm ile fetal KKH arasında potansiyel bir ilişki olabileceğini göstermektedir.

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Cite This Article

Yukcu, B., Albayrak, M. (2025). Association between second trimester maternal hypothyroidism and congenital heart diseases in fetuses: a retrospective study. Turkish Journal of Clinics and Laboratory, Cilt: 16 Sayı: 2, 322–329. https://doi.org/10.18663/tjcl.1613893

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