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Journals / Turkish Journal of Veterinary and Animal Sciences / 2006 / Cilt: 30 - Sayı: 5

The Effects on Myocardial Improvement Using ATP-MgCl2 during the Ischemia Reperfusion Period; An In Vitro Study

Nusret APAYDIN
Zülfikar Kadir SARITAŞ
Kamuran PAMUK
Eser ÖZGENCİL
Fulya OCAK
Tulga ULUS
Baran BUDAK
Selçuk SÜRÜCÜ
Salih Fehmi KATIRCIOĞLU
Pages
449–456
Publication Date
2006-05-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the near future, with the help of more comprehensive studies, ATP-MgCl2 is expected to be used routinely because of its potential benefits.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We investigated the effect of ATP-MgCl2 on myocardial hemodynamics and ultrastructure.
📊
Key Findings & Data:In the in vitro study, left ventricular systolic and diastolic pressures and dp/dt values were significantly high in the ATP-MgCl2 group beginning from 0.5 h of the reperfusion period.
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Conclusion & Impact:In the near future, with the help of more comprehensive studies, ATP-MgCl2 is expected to be used routinely because of its potential benefits.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:In vitro perfusion · ischemia-reperfusion damage · myocardium

Abstract

We investigated the effect of ATP-MgCl2 on myocardial hemodynamics and ultrastructure. In the in vitro study, left ventricular systolic and diastolic pressures and dp/dt values were significantly high in the ATP-MgCl2 group beginning from 0.5 h of the reperfusion period. In the ATP-MgCl2 group, at the end of the third hour, systolic and diastolic pressure values were 80.0 ± 6.2 and 75.2 ± 7.2 mmHg, while in the control group they were 18.4 ± 7.7 and 7.5 ± 6.8 mmHg (P < 0.05). In the ultrastructural analysis, myofibrillary damage was observed in both groups, but the mitochondrial pathologic changes were clearer in the control group. The electron microscopic score was 0.40 ± 0.061 in the ATP-MgCl2 group and 1.2 ± 0.039 in the control group (P < 0.001). The hemodynamic and ultrastructural parameters of the specimens investigated in this study revealed that the usage of ATP-MgCl2 may be beneficial in coping with ischemia-reperfusion damage. In the near future, with the help of more comprehensive studies, ATP-MgCl2 is expected to be used routinely because of its potential benefits.

Özet

We investigated the effect of ATP-MgCl2 on myocardial hemodynamics and ultrastructure. In the in vitro study, left ventricular systolic and diastolic pressures and dp/dt values were significantly high in the ATP-MgCl2 group beginning from 0.5 h of the reperfusion period. In the ATP-MgCl2 group, at the end of the third hour, systolic and diastolic pressure values were 80.0 ± 6.2 and 75.2 ± 7.2 mmHg, while in the control group they were 18.4 ± 7.7 and 7.5 ± 6.8 mmHg (P < 0.05). In the ultrastructural analysis, myofibrillary damage was observed in both groups, but the mitochondrial pathologic changes were clearer in the control group. The electron microscopic score was 0.40 ± 0.061 in the ATP-MgCl2 group and 1.2 ± 0.039 in the control group (P < 0.001). The hemodynamic and ultrastructural parameters of the specimens investigated in this study revealed that the usage of ATP-MgCl2 may be beneficial in coping with ischemia-reperfusion damage. In the near future, with the help of more comprehensive studies, ATP-MgCl2 is expected to be used routinely because of its potential benefits.

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Cite This Article

APAYDIN, N., SARITAŞ, Z. K., PAMUK, K., ÖZGENCİL, E., OCAK, F., ULUS, T., BUDAK, B., SÜRÜCÜ, S., KATIRCIOĞLU, S. F. (2006). The Effects on Myocardial Improvement Using ATP-MgCl2 during the Ischemia Reperfusion Period; An In Vitro Study. Turkish Journal of Veterinary and Animal Sciences, Cilt: 30 - Sayı: 5, 449–456. https://ajindex.com/articles/132336

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