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Journals / Uludağ Üniversitesi Mühendislik Fakültesi Dergisi / 2017 / Cilt: 22 Sayı: 3

Production and Crosslinking of Polysaccharide Based Nanofibrous Mat for Biomedical Applications

BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI

Şerife Şafak(NAMIK KEMAL ÜNİVERSİTESİ, ÇORLU MÜHENDİSLİK FAKÜLTESİ)
Esra Karaca(ULUDAĞ ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ)
Pages
127–144
Publication Date
2017-12-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicated that the nanofibrous mat was become resistant to water without any deformation of nanofibrous structure with the crosslinking application.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Polysaccharide based polymers are widely used in biomedical applications.
📊
Key Findings & Data:Resultant nanofibrous mat was crosslinked with 1-etil-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide solution to develop its water resistance.
💡
Conclusion & Impact:The results indicated that the nanofibrous mat was become resistant to water without any deformation of nanofibrous structure with the crosslinking application.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Hyaluronik asit · karboksimetil selüloz · sodyum alginat

Abstract

Polysaccharide based polymers are widely used in biomedical applications. In this study, nanofibrous mat was produced from hyaluronic acid, carboxymethyl cellulose and sodium alginate polysaccharide polymers via electrospinning method. Resultant nanofibrous mat was crosslinked with 1-etil-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide solution to develop its water resistance. Before and after the crosslinking process, nanofibrous mat was characterized by scanning electron microscope, fourier transform infrared spectrometry, atomic force microscope, BET analysis and water resistance test. The results indicated that the nanofibrous mat was become resistant to water without any deformation of nanofibrous structure with the crosslinking application.

Özet

Polisakkarit esaslı polimerler, biyomedikal uygulamalarda yaygın olarak kullanılmaktadır. Bu çalışmada; polisakkarit hyaluronik asit, karboksimetil selüloz ve sodyum alginat polimerleri kullanılarak elektro çekim yöntemiyle nanolifli yüzey üretimi gerçekleştirilmiştir. Üretilen nanolifli yüzeye, suya dayanımını geliştirmek amacıyla, 1-etil-3-(3-dimetilaminopropil) karbodiimid hidroklorit ve N-hidroksisülfosüksinimit karışımı ile çapraz bağlama işlemi uygulanmıştır. Nanolifli yüzey, çapraz bağlama işlemi öncesi ve sonrasında, taramalı elektron mikroskobu, fourier transform infrared spektrometresi, atomik kuvvet mikroskobu, BET analizi ve suya dayanım testi ile karakterize edilmiştir. Sonuçlar; çapraz bağlama işlemi ile lifli yapının deformasyona uğramadan nanolifli yüzeyin suya dayanıklı hale geldiğini göstermiştir.

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Cite This Article

Şafak, Ş., Karaca, E. (2017). Production and Crosslinking of Polysaccharide Based Nanofibrous Mat for Biomedical Applications. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi, Cilt: 22 Sayı: 3, 127–144. https://doi.org/10.17482/uumfd.309657

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